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'''Perforin''' ({{lang-en|perforin, PRF}}) adalah [[sitokinasitokin]] berupa [[protein]] yang diekspresikan oleh [[gen]] PRF1.<ref name="pmid1505959">{{cite journal | author = Fink TM, Zimmer M, Weitz S, Tschopp J, Jenne DE, Lichter P | title = Human perforin (PRF1) maps to 10q22, a region that is syntenic with mouse chromosome 10 | journal = Genomics | volume = 13 | issue = 4 | pages = 1300–2 | year = 1992 | month = Sep | pmid = 1505959 | pmc = | doi = }}</ref><ref name="pmid2592021">{{cite journal | author = Shinkai Y, Yoshida MC, Maeda K, Kobata T, Maruyama K, Yodoi J, Yagita H, Okumura K | title = Molecular cloning and chromosomal assignment of a human perforin (PFP) gene | journal = Immunogenetics | volume = 30 | issue = 6 | pages = 452–7 | year = 1990 | month = Jan | pmid = 2592021 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRF1 perforin 1 (pore forming protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5551| accessdate = }}</ref>
Perforin dapat ditemukan pada [[granula|granul]] [[sel T]] CD8 dan [[sel NK]]. Setelah proses [[degranulasi]], sekresi perforin akan tersisipkan pada [[membran sel]] dan membentuk sebuah lobanglubang. Bagian perforin yang menancap pada membran tersebut adalah domain [[MACPF]].<ref>{{cite journal |author=Tschopp J, Masson D, Stanley KK |title=Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis |journal=Nature |volume=322 |issue=6082 |pages=831–4 |year=1986 |pmid=2427956 |doi=10.1038/322831a0}}</ref>
Perforin bersinergi dengan ''membrane-attack complex'' (MAC) yang dilakukan protein [[komplemen]] seperti [[C5a]] dan [[C5b]].<ref>{{en}} {{cite book
|title = Immunobiology
|author = Janeway, Charles A.; Travers, Paul; Walport, Mark; Shlomchik, Mark
