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Revisi per 10 Juni 2016 05.53 sunting Helito (bicara \| kontrib) Peninjau otomatis 3.865 suntingan Tidak ada ringkasan suntingan ← Revisi sebelumnya		Revisi terkini sejak 28 April 2020 19.37 sunting balikkan Aɳɳaaa (bicara \| kontrib) 854 suntingan →Peran GPR56 Tag: Suntingan perangkat seluler Suntingan peramban seluler
(10 revisi perantara oleh 3 pengguna tidak ditampilkan)
Baris 1: '''GPR56''' adalah anggota dari [[GPCR adhesi]] (''adhesion GPCR'']]).<ref>{{cite journal \| vauthors = Langenhan T, Aust G, Hamann J \| title = Sticky signaling--adhesion class G protein-coupled receptors take the stage \| journal = Sci Signal. \| volume = 6 \| issue = 276 \| pages = \| year = 2007 \| pmid = 23695165 \| doi = 10.1126/scisignal.2003825}}</ref> == Ligan == [[Ligan\|Ligan-ligan]] yang berinteraksi dengan GPR56: * [[transglutaminse]] 2 (TG2)<ref>{{cite journal \| vauthors = Xu L, Begum S, Hearn JD, Hynes RO \| title = GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis \| journal = Proc Natl Acad Sci USA \| volume = 103 \| issue = 24 \| pages = 9023-8 \| year = 2006 \| pmid = 16757564 \| pmc = 1474142 \| doi = }}</ref> * Transglutaminse 2 (TG2) * ~~Kolagen~~[[kolagen]] III<ref>{{cite journal \| vauthors = Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X \| title = G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination \| journal = Proc Natl Acad Sci USA \| volume = 108 \| issue = 31 \| pages = 12925-30 \| year = 2011 \| pmid = 21768377 \| pmc = 3150909 \| doi = 10.1073/pnas.1104821108}}</ref> * ~~Heparin~~[[heparin]]<ref>{{cite journal \| vauthors = Chiang NY, Chang GW, Huang YS, Peng YM, Hsiao CC, Kuo ML, Lin HH \| title = Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility \| journal = J Cell Sci. \| volume = 129 \| issue = 11 \| pages = \| year = 2016 \| pmid = 27068534 \| doi = 10.1242/jcs.174458}}</ref> ==~~Peran~~ ~~GPR56~~Ekspresi == GPR56 diekspresikan pada: * sel NK CD56<sup>dim</sup> manusia * sel T CD27<sup>-</sup>CD45RA<sup>+</sup> (sel T sitotoksik reaktif) * ~~Reseptor~~sel ~~penghambat~~NK ~~pada~~memori-like ~~sel~~berumur NKpanjang<ref name="nk">{{cite journal \| vauthors = Chang GW, Hsiao CC, Peng YM, Vieira Braga FA, Kragten NA, Remmerswaal EB, et al \| title = The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells \| journal = Cell Rep. \| volume = 15 \| issue = 8 \| pages = 1757-70 \| year = 2016 \| pmid = 27184850 \| doi = 10.1016/j.celrep.2016.04.053}}</ref>▼ Ekspresi GPR56 diinduksi oleh [[faktor transkripsi]] [[Hobit]] (''homolog of [[Blimp-1]]''). Pada manusia, Hobit diekspresikan pada sel NK dan sel T ''quiescent'', sangat dekat kecocokannya dengan ekspresi GPR56.<ref>{{cite journal \| vauthors = Vieira Braga FA, Hertoghs KM, Kragten NA, Doody GM, Barnes NA, Remmerswaal EB, et al \| title = Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans \| journal = Eur J Immunol. \| volume = 45 \| issue = 10 \| pages = 2945-58 \| year = 2015 \| pmid = 26179882 \| doi = 10.1002/eji.201545650}}</ref> == Peran GPR56 == GPR56 banyak berperan dalam proses-proses berikut: * ~~Pembentukan~~pembentukan dan penjagaan sel ~~punca~~puncak hematopoietik * ~~Perkembangan~~perkembangan kortikal * ~~Kesuburan~~kesuburan pria * ~~Hipertropi~~hipertropi otot * ~~Pertumbuhan~~pertumbuhan dan progesi melanoma * reseptor penghambat pada sel NK<ref name="nk" /> ▲* Reseptor penghambat pada sel NK<ref>{{cite journal \| vauthors = Chang GW, Hsiao CC, Peng YM, Vieira Braga FA, Kragten NA, Remmerswaal EB, et al \| title = The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells \| journal = Cell Rep. \| volume = 15 \| issue = 8 \| pages = 1757-70 \| year = 2016 \| pmid = 27184850 \| doi = 10.1016/j.celrep.2016.04.053}}</ref> * ~~Menghambat~~menghambat migrasi sel NK baik secara spontan maupun distimulasi SDF-1<ref>{{cite journal \| vauthors = Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, et al \| title = Specific expression of GPR56 by human cytotoxic lymphocytes \| journal = J Leukoc Biol. \| volume = 90 \| issue = 4 \| pages = 735-40 \| year = 2011 \| pmid = 21724806 \| doi = 10.1189/jlb.0211092}}</ref> == Mutasi pada ''GPR56'' == Mutasi pada ''GPR56'' menyebabkan malformasi otak manusia dinamakan ''[[bilateral frontoparietal polymicrogyria]]'' (BFPP).<ref name="piao">{{cite journal \| vauthors = Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, et al \| title = G protein-coupled receptor-dependent development of human frontal cortex \| journal = Science \| volume = 303 \| issue = 5666 \| pages = 2033-6 \| year = 2004 \| pmid = 15044805 \| doi = }}</ref> Ada 13 mutasi berbeda pada pasien BFPP, termasuk 1 delesi, 2 ''splicing'', dan 10 mutasi ''missense''.<ref name="piao" /> Jenis-jenis mutasi: * R565W, terjadi mutasi pada simpul ekstraseluler kedua mutasi ini menghambat ekspresi reseptor di permukaan sel * R38Q * R38W * Y88C * C91S keempat mutasi terjadi pada ujung N, menghasilkan protein dengan penurunan lalu lintas intraselular dan rendahnya ekspresi pada permukaan sel * C346S * W349S kedua mutasi ini terjadi pada domain GAIN membuat protein dengan pemecahan terganggu secara dramatis sehingga gagal diangkut ke retikulum endoplasma == Transduksi sinyal == Molekul sinyal yang terlibat dalam transduksi sinyal GPR56 meliputi: * Gαq/11<ref>{{cite journal \| vauthors = Little KD, Hemler ME, Stipp CS \| title = Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association \| journal = Mol Biol Cell. \| volume = 15 \| issue = 5 \| pages = 2375-87 \| year = 2004 \| pmid = 15004227 \| pmc = 404030 \| doi = }}</ref> Baris 26 ⟶ 44: * PKCα * mTOR == Referensi == {{reflist\|colwidth=30em}} [[Kategori:~~Farmakologi~~GPCR ~~Molekuler~~adhesi]]