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Baris 1: ~~{{inuse}}~~ {{Drugbox \| IUPAC_name = 2-methylsulfanyl-6-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-7(4''H'')-one Baris 7 ⟶ 6: \| tradename = \| legal_US = Investigational New Drug \| legal_status = <!--Pharmacokinetic data--> Baris 30 ⟶ 29: }} '''Triazavirin''' ('''TZV''', '''Riamilovir''') adalah antivirus analog [[nukleotida ~~nukleotida~~]] yang awalnya dikembangkan di Rusia yang telah menunjukkan kemanjuran terhadap [[influenza]] A dan B, termasuk strain [[H5n1\|H5N1]].<ref>{{Cite journal\|last=Kiselev\|first=O. I.\|last2=Deeva\|first2=E. G.\|last3=Mel'nikova\|first3=T. I.\|last4=Kozeletskaia\|first4=K. N.\|last5=Kiselev\|first5=A. S.\|last6=Rusinov\|first6=V. L.\|last7=Charushin\|first7=V. N.\|last8=Chupakhin\|first8=O. N.\|date=2012-11\|title=[A new antiviral drug Triazavirin: results of phase II clinical trial]\|url=https://www.ncbi.nlm.nih.gov/pubmed/23477247\|journal=Voprosy Virusologii\|volume=57\|issue=6\|pages=9–12\|issn=0507-4088\|pmid=23477247}}</ref><ref>{{Cite journal\|last=Vincent\|first=Martin J.\|last2=Bergeron\|first2=Eric\|last3=Benjannet\|first3=Suzanne\|last4=Erickson\|first4=Bobbie R.\|last5=Rollin\|first5=Pierre E.\|last6=Ksiazek\|first6=Thomas G.\|last7=Seidah\|first7=Nabil G.\|last8=Nichol\|first8=Stuart T.\|date=2005-08-22\|title=Chloroquine is a potent inhibitor of SARS coronavirus infection and spread\|url=https://www.ncbi.nlm.nih.gov/pubmed/16115318\|journal=Virology Journal\|volume=2\|pages=69\|doi=10.1186/1743-422X-2-69\|issn=1743-422X\|pmc=1232869\|pmid=16115318}}</ref><ref>{{Cite journal\|last=Karpenko\|first=Inna\|last2=Deev\|first2=Sergey\|last3=Kiselev\|first3=Oleg\|last4=Charushin\|first4=Valerey\|last5=Rusinov\|first5=Vladimir\|last6=Ulomsky\|first6=Eugeney\|last7=Deeva\|first7=Ella\|last8=Yanvarev\|first8=Dmitry\|last9=Ivanov\|first9=Alexander\|date=2010-05\|title=Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication\|url=https://www.ncbi.nlm.nih.gov/pubmed/20194696\|journal=Antimicrobial Agents and Chemotherapy\|volume=54\|issue=5\|pages=2017–2022\|doi=10.1128/AAC.01186-09\|issn=1098-6596\|pmc=2863629\|pmid=20194696}}</ref><ref>{{Cite journal\|last=Shvetsov\|first=Alexey V.\|last2=Zabrodskaya\|first2=Yana A.\|last3=Nekrasov\|first3=Peter A.\|last4=Egorov\|first4=Vladimir V.\|date=2018-07-27\|title=Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure\|url=https://doi.org/10.1080/07391102.2017.1367329\|journal=Journal of Biomolecular Structure and Dynamics\|volume=36\|issue=10\|pages=2694–2698\|doi=10.1080/07391102.2017.1367329\|issn=0739-1102\|pmid=28828928}}</ref> Menurut riset, {{PAGENAMEPURE}} tampaknya mampu mengurangi dampak dari penyakit flu dan juga komplikasi penyakit terkait.<ref>{{Cite web\|url=https://www.rt.com/russia/480037-china-tests-russian-drug-coronavirus/\|title=China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'\|website=RT International\|language=en\|access-date=2020-04-20}}</ref> ~~<references />~~ Antivirus ini memiliki inti dari ''novel triazolotriazine,'' yang mewakili kelas struktural baru dari obat-obatan antivirus non-nukleosida.<ref name=":0">{{Cite journal\|last=Rusinov\|first=Vladimir L.\|last2=Sapozhnikova\|first2=Irina M.\|last3=Ulomskii\|first3=Evgeny N.\|last4=Medvedeva\|first4=Natalia R.\|last5=Egorov\|first5=Vladimir V.\|last6=Kiselev\|first6=Oleg I.\|last7=Deeva\|first7=Ella G.\|last8=Vasin\|first8=Andrey V.\|last9=Chupakhin\|first9=Oleg N.\|date=2015-03-01\|title=Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins\|url=https://doi.org/10.1007/s10593-015-1695-4\|journal=Chemistry of Heterocyclic Compounds\|language=en \|volume=51\|issue=3\|pages=275–280\|doi=10.1007/s10593-015-1695-4\|issn=1573-8353}}</ref> ==Manfaat== Triazavirin pada mulanya dikembangkan di [[Akademi Ilmu Pengetahuan Rusia]], Universitas Federal Ural di [[Ekaterinburg]], [[Rusia]] yang dikembangkan untuk mengatasi wabah dari virus [[Flu burung\|Flu Burung]] ([[H5N1]]), kemudian dikarenakan terdapat beberapa persamaan dengan [[koronavirus]], maka para peneliti merasa perlu untuk mencoba meneliti khasiat obatnya pada pasien korona.<ref name=":0" /><ref name=loginova>Loginova SIa, Borisevich SV, Maksimov VA, et al. Antibiot Khimioter. 2007;52(11-12):18‐20.</ref><ref name=":1">{{Cite web\|url=https://pubmed.ncbi.nlm.nih.gov/19275052/\|title=[Investigation of Triazavirin Antiviral Activity Against Influenza A Virus (H5N1) in Cell Culture]\|last=SIa\|first=Loginova\|last2=Sv\|first2=Borisevich\|date=2007\|website=Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]\|language=en\|pmid=19275052\|access-date=2020-05-03\|last3=Va\|first3=Maksimov\|last4=Vp\|first4=Bondarev\|last5=Sk\|first5=Kotovskaia\|last6=Vl\|first6=Rusinov\|last7=Vn\|first7=Charushin}}</ref> Sebagian besar penelitian dilakukan dalam rangka menguji aktivitas anti-infuenza.<ref name="loginova" /><ref name=":1" /> == Referensi ==