Protein tau: Perbedaan antara revisi
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{{distinguish|Taurina}}
'''Protein tau''' ({{lang-en|microtubule-associated protein tau, MAPT}}) adalah [[protein]] yang membuat [[mikrotubula]] menjadi stabil. Protein tau terdapat sangat banyak pada [[neuron]] di dalam [[sistem saraf pusat]], dan jarang terdapat di lokasi lain.
Protein tau berinteraksi dengan:
==Rujukan==▼
* domain SH3 dari [[Fyn kinase]], sebuah [[enzim]] dengan peran penting dalam proses [[mielinasi]] dan diferensiasi morfologis [[oligodendrosit]]<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/11826099
| title = Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau
| accessdate = 2010-06-27
| work = Departments of Neurobiology and Immunology, University of Heidelberg; Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J.
}}</ref>
* domain terminus-C [[sinuklein]]-alfa, sebuah protein yang terdapat dalam patogenesis beberapa kelainan saraf seperti [[penyakit Parkinson]] dan [[lesi]] seperti [[badan Lewy]]. Sinuklein-alfa kemudian menstimulasi [[protein kinase A]] untuk menginduksi [[fosforilasi]] protein tau.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/10464279
| title = alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
| accessdate = 2010-06-27
| work = Department of Medical Biochemistry, University of Aarhus; Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R.
}}</ref> Proses fosforilasi juga di[[katalis]]asi oleh ''cAMP-dependent'' [[protein kinase]] setelah protein tau terikat pada [[protein 14-3-3zeta]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/10840038
| title = 14-3-3zeta is an effector of tau protein phosphorylation
| accessdate = 2010-06-27
| work = Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University; Hashiguchi M, Sobue K, Paudel HK.
}}</ref>
* domain pengikat [[seng]] dari [[protein S100]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/11264299
| title = S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease
| accessdate = 2010-06-27
| work = Centre for Research in Neurodegenerative Diseases, Department of Pharmacology, University of Toronto; Yu WH, Fraser PE
}}</ref><ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/2833519
| title = Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II
| accessdate = 2010-06-27
| work = Department of Biochemistry, University of California; Baudier J, Cole RD
}}</ref>
▲== Rujukan ==
{{reflist}}
== Lihat pula ==
* [[Filamen PH]]
* [[Neurita]]
{{Biokimia-stub}}▼
[[Kategori:Protein]]
▲{{Biokimia-stub}}
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