Protein Kinase B: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
k minor changes |
k →Rujukan: clean up |
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{{Redirect|AKT}}
{{infobox protein
|Name=[[AKT1]]
|image=Crystal structure of Akt-1-inhibitor complexes.png
|caption=Representasi pita dari struktur kristal kompleks ''Akt-1-inhibitor''.<ref name="pmid20481595">{{PDB|3MV5}}; {{cite journal | vauthors = Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J | display-authors = 6 | title = Design of selective, ATP-competitive inhibitors of Akt | journal = Journal of Medicinal Chemistry | volume = 53 | issue = 12 | pages = 4615–22 | date = June 2010 | pmid = 20481595 | doi = 10.1021/jm1003842 }}</ref>
|width=
|HGNCid=391
|Symbol=[[AKT1]]
|AltSymbols=
|EntrezGene=207
|OMIM=164730
|RefSeq=NM_005163
|UniProt=P31749
|PDB=
|ECnumber=
|Chromosome=14
|Arm=q
|Band=32.32
|LocusSupplementaryData=-32.33
}}
{{infobox protein
|Name=[[AKT2]]
|image=3D0E Ribbon.png
|caption=Struktur kristal kompleks ''Akt-2-inhibitor''.<ref name="pmid18800763">{{PDB|3D0E}}; {{cite journal | vauthors = Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R | display-authors = 6 | title = Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase | journal = Journal of Medicinal Chemistry | volume = 51 | issue = 18 | pages = 5663–79 | date = September 2008 | pmid = 18800763 | doi = 10.1021/jm8004527 | url = https://figshare.com/articles/Identification_of_4_2_4_Amino_1_2_5_oxadiazol_3_yl_1_ethyl_7_3_i_S_i_3_piperidinylmethyl_oxy_1_i_H_i_imidazo_4_5_i_c_i_pyridin_4_yl_2_methyl_3_butyn_2_ol_GSK690693_a_Novel_Inhibitor_of_AKT_Kinase/2911615 }}</ref>
|HGNCid=392
|Symbol=[[AKT2]]
|AltSymbols=
|EntrezGene=208
|OMIM=164731
|RefSeq=NM_001626
|UniProt=P31751
|PDB=
|ECnumber=
|Chromosome=19
|Arm=q
|Band=13.1
|LocusSupplementaryData=-13.2
}}
{{infobox protein
|Name=[[AKT3]]
|caption=
|image=
|width=
|HGNCid=393
|Symbol=[[AKT3]]
|AltSymbols=
|EntrezGene=10000
|OMIM=611223
|RefSeq=NM_181690
|UniProt=Q9Y243
|PDB=
|ECnumber=
|Chromosome=1
|Arm=q
|Band=43
|LocusSupplementaryData=-44
}}
'''Kinase PB''' ({{lang-en|protein kinase b, PKB, RAC, Akt}}) adalah [[kinase protein]] dari golongan [[kinase AGC]] yang menyebabkan inaktivasi [[glikogen sintase kinase-3]].<ref name="hem-ref">{{en}} {{cite web|url=http://www.cloetta-stiftung.ch/hemmings-ref.pdf|title=PROTEIN KINASE B (PKB/AKT) – A COMMON ELEMENT IN MULTIPLE SIGNALING PATHWAYS INVOLVED IN INSULIN SIGNALING, CELL SURVIVALAND CANCER|accessdate=2011-07-13|work=Brian A. Hemmings|archiveurl=https://web.archive.org/web/20041020071101/http://www.cloetta-stiftung.ch/hemmings-ref.pdf|archivedate=2004-10-20|dead-url=no}}</ref>
Akt diaktivasi melalui [[lintasan metabolisme|lintasan]] ''receptor tyrosine kinase'', seperti ''platelet-derived growth factor receptor'' (PDGF-R), [[insulin]], ''epidermal growth factor'' (EGF), ''basic fibroblast growth factor'' (bFGF), and ''insulin-like growth factor I'' (IGF-I),<ref>{{en}} {{cite web
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