KEGG: Perbedaan antara revisi

The KEGG database project was initiated in 1995 by Minoru Kanehisa, Professor at the Institute for Chemical Research, [[Kyoto University]], under the then ongoing Japanese [[Human Genome Project|Human Genome Program]].<ref name="pmid10592173">{{cite journal| author=Kanehisa M, Goto S | title=KEGG: Kyoto Encyclopedia of Genes and Genomes | journal=Nucleic Acids Res | year=2000 | volume=28 | issue=1 | pages=27–30 | pmid=10592173 | doi=10.1093/nar/28.1.27 | pmc=102409 }}</ref><ref name="pmid9287494">{{cite journal| author=Kanehisa M | title=A database for post-genome analysis | journal=Trends Genet | year=1997 | volume=13 | issue=9 | pages=375–6 | pmid=9287494 | doi=10.1016/S0168-9525(97)01223-7 }}</ref> Foreseeing the need for a computerized resource that can be used for biological interpretation of [[genome project|genome sequence data]], he started developing the KEGG PATHWAY database. It is a collection of manually drawn KEGG pathway maps representing experimental knowledge on [[metabolism]] and various other functions of the [[cell (biology)|cell]] and the [[organism]]. Each pathway map contains a network of molecular interactions and reactions and is designed to link [[gene]]s in the genome to [[gene product]]s (mostly [[protein]]s) in the pathway. This has enabled the analysis called KEGG pathway mapping, whereby the gene content in the genome is compared with the KEGG PATHWAY database to examine which pathways and associated functions are likely to be encoded in the genome.▼

According to the developers, KEGG is a "computer representation" of the [[biological system]].<ref name="pmid16381885">{{cite journal| author=Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M | title=From genomics to chemical genomics: new developments in KEGG | journal=Nucleic Acids Res | year=2006 | volume=34 | issue=Database issue | pages=D354–7 | pmid=16381885 | doi=10.1093/nar/gkj102 | pmc=1347464 }}</ref> It integrates building blocks and wiring diagrams of the system — more specifically, genetic building blocks of genes and proteins, chemical building blocks of [[small molecule]]s and reactions, and wiring diagrams of molecular interaction and reaction networks. This concept is realized in the following databases of KEGG, which are categorized into systems, genomic, chemical, and health information.<ref name="pmid24214961">{{cite journal| author=Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M, Tanabe M | title=Data, information, knowledge and principle: back to metabolism in KEGG | journal=Nucleic Acids Res | year=2014 | volume=42 | issue=Database issue | pages=D199-205 | pmid=24214961 | doi=10.1093/nar/gkt1076 | pmc=3965122 }}</ref>▼