Kalsitriol: Perbedaan antara revisi
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| routes_of_administration = Oral, [[intravenous|IV]], topical
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'''Kalsitriol''' ({{lang-en|1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D3, 1,25-(OH)<sub>2</sub>D<sub>3</sub>}}) adalah [[hormon]] [[pleitrofik]] yang merupakan bentuk aktif [[vitamin D]] setelah proses konversi oleh [[ginjal]],<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/sites/ppmc/articles/PMC2737618
| title = Analysis of SNPs and Haplotypes in Vitamin D Pathway Genes and Renal Cancer Risk
| accessdate = 2010-12-10
| work = Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, International Agency for Research on Cancer, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Institute of Public Health, Institute of Carcinogenesis, Cancer Research Centre, Department of Preventive Medicine, Faculty of Medicine, Palacky University, Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Department of Epidemiology, Institute of Occupational Medicine, Ohio State University Medical Center; Sara Karami, Paul Brennan, Philip S. Rosenberg, Marie Navratilova, Dana Mates, David Zaridze, Vladimir Janout, Helena Kollarova, Vladimir Bencko, Vsevolod Matveev, Neonila Szeszenia-Dabrowska, Ivana Holcatova, Meredith Yeager, Stephen Chanock, Idan Menashe, Nathaniel Rothman, Wong-Ho Chow, Paolo Boffetta, dan Lee E. Moore
}}</ref> terhadap [[kalsidiol]] yang di[[sekresi]] oleh [[hati]],<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950664
| title = Vitamin D Deficiency and Liver Disease
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| work = Medicine Medical Director of Liver Transplantation University of Tennessee Health Science Center; Satheesh Nair
| quote = The liver produces 25-hydroxy (25-OH) vitamin D, also known as calcidiol, the immediate precursor to the metabolically active 1,25 dihydroxyvitamin D 1-25 vitamin D, also known as calcitriol.
}}</ref> dengan [[katalis]] berupa [[enzim]] [[sitokrom P450]] [[hidroksilase 1-alfa]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/10589683
| title = Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney.
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}}</ref>
Kalsitriol memiliki sifat anti-[[proliferasi|proliferatif]], pro-[[apoptosis|apoptotik]] dan pro-[[diferensiasi]] terhadap berbagai jenis [[sel (biologi)|sel]] [[tubuh]], dan sifat anti-[[kanker]], seperti [[kanker prostat]], [[kanker usus besar]],<ref name="PM14696037">{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/14696037
| title = The pleiotropic actions of vitamin D
| accessdate = 2010-12-10
| work = Department of Physiology, McGill University; Lin R, White JH.
}}</ref> [[kanker indung telur]], [[kanker payudara]], [[
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583388
| title = Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
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| work = Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Massachusetts General Hospital, Endocrine Unit; Roger Bouillon, Geert Carmeliet, Lieve Verlinden, Evelyne van Etten, Annemieke Verstuyf, Hilary F. Luderer, Liesbet Lieben, Chantal Mathieu, dan Marie Demay
| quote = To gain more insight into the antiproliferative and prodifferentiating effect of 1,25-(OH)2D, genomic profiling has been performed in malignant cells such as prostate (127,128,129,130,131,132,133), breast (134,135,136), leukemia (137,138), colon (139), and ovarian cancer (140) cells, and squamous cell carcinoma cells (141). Since then, the antineoplastic activity of 1,25-(OH)2D was shown both in vitro and in vivo in a wide variety of malignancies, such as leukemia (266,267) and colon (268,269), breast (270,271,272), and prostate cancer (273,274).
}}</ref> oleh kapasitas regulasi terhadap [[metabolisme]] [[kalsium]] dan [[ortofosfat|fosfat]],<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/15970529
| title = Vitamin D and cancer: an update of in vitro and in vivo data
| accessdate = 2010-12-10
| work = Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid; Ordonez-Moran P, Larriba MJ, Pendas-Franco N, Aguilera O, Gonzalez-Sancho JM, Munoz A.
}}</ref><ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/15570055
| title = Vitamin D and colon carcinogenesis
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}}</ref> serta [[modulasi]] [[sistem kekebalan]] dan fungsi [[sistem saraf pusat]].<ref name="PM14696037" />
Kalsitriol akan dikonversi menjadi [[asam kalsitroat]] sebelum di[[ekskresi]] melalui [[empedu]],<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133244/pdf/biochemj00201-0174.pdf
| title = Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid, Evidence for a pathway in kidney and bone involving 24-oxidation
| accessdate = 2010-12-10
| work = Department of Biochemistry, Queen's University, Human Nutrition Research Center on Aging, Tufts University; Guy MAKIN, David LOHNES, Valarie BYFORD, Rahul RAY dan Glenville JONES
}}</ref> atau [[urin]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853332
| title = Vitamin D Metabolism: New Concepts and Clinical Implications
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== Rujukan ==
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