Reseptor serotonin: Perbedaan antara revisi
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'''Reseptor serotonin''' atau juga dikenal sebagai '''reseptor 5-hidroksitriptamin''' atau '''reseptor 5-HT''' adalah kelompok dari [[reseptor terhubung-protein G]] dan [[reseptor kanal ion]] (''ligand-gated ion channels'', LGIC) yang ditemukan pada [[sistem saraf pusat]] dan [[sistem saraf tepi]].<ref name="pmid7938165">{{cite journal |vauthors=Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP | title = International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) | journal = Pharmacol. Rev. | volume = 46 | issue = 2 | pages = 157–203 | year = 1994 | pmid = 7938165 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/46/2/157}}</ref><ref name="isbn0-397-51820-X">{{cite book |vauthors=Frazer A, Hensler JG |veditors=Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD | title = Basic Neurochemistry: Molecular, Cellular, and Medical Aspects | publisher = Lippincott-Raven | location = Philadelphia | year = 1999| pages = 263–292| isbn = 0-397-51820-X | oclc = | doi = | chapter= Chapter 13: Serotonin Receptors | chapterurl = http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=bnchm.section.963 | accessdate = 2008-04-11 }}</ref> Reseptor serotonin memperantarai neurotransmisi eksitatori (pemicuan) dan inhibitori (penghambatan) yang beraksi terhadap ligan alaminya.
== Klasifikasi ==
Dengan pengecualian dari reseptor 5-HT3, semua reseptor serotonin termasuk dalam [[reseptor terhubung-protein G]] yang mengaktifkan kaskade kurir kedua untuk menghasilkan respons eksitatori atau inhibitori (penghambatan). Pada tahun 2014 sebuah reseptor 5-HT novel dideskripsikan yang diisolasi dari kupu-kupu putih kecil, ''Pieris rapae'', dan diberi nama pr5-HT8. Kesamaan relatif antara reseptor ini dengan kelas reseptor 5-HT lainnya bersifat rendah dan tidak terdapat pada mamalia.<ref name="pmid25187179">{{cite journal |vauthors=Qi YX, Xia RY, Wu YS, Stanley D, Huang J, Ye GY |title=Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor |journal=J. Neurochem. |volume= 131|issue= |pages= 767–77|year=2014 |pmid=25187179 |doi=10.1111/jnc.12940 |url=}}</ref>
==
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==
Tujuh kelas reseptor serotonin mencakup total 14 reseptor serotonin dikenal.<ref name="NHM-14 receptors">{{cite book |vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | title = Molecular Neuropharmacology: A Foundation for Clinical Neuroscience | year = 2009 | publisher = McGraw-Hill Medical | location = New York | isbn = 978-0-07-148127-4 | page = 4 | edition = 2nd |quote = Similarly, little is known about which of serotonin’s 14 known receptors must be activated to achieve an antidepressant response. }}</ref> Jenis tertentu telah ditandai sebagai berikut:<ref name="urlSerotonin Receptor Subtypes and Ligands">{{cite web | url = http://www.acnp.org/g4/GN401000039/Ch039.html | title = Serotonin Receptor Subtypes and Ligands | accessdate = 2008-04-11 |vauthors=Glennon RA, Dukat M, Westkaemper RB | date = 2000-01-01 | work = | publisher = American College of Neurophyscopharmacology | pages = | language = | quote = | archiveurl= https://web.archive.org/web/20080421160353/http://www.acnp.org/g4/GN401000039/Ch039.html| archivedate= 21 April 2008 <!--DASHBot-->| deadurl= no}}</ref><ref name="urlIUPHAR DATABASE | 5-HYDROXYTRYPTAMINE RECEPTORS">{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1288 | title = 5-Hydroxytryptamine Receptors | accessdate = 2008-04-11 | date = | format = | work = IUPHAR Receptor Database | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}</ref><ref name="Wesolowska_2002">{{cite journal |author=Wesolowska A |title=In the search for selective ligands of 5-HT<sub>5</sub>, 5-HT<sub>6</sub> and 5-HT<sub>7</sub> serotonin receptors |journal=Polish Journal of Pharmacology |volume=54 |issue=4 |pages=327–41 |year=2002 |pmid=12523486 |url=http://www.if-pan.krakow.pl/pjp/pdf/2002/4_327.pdf|format=PDF}}</ref>
{| class="wikitable"
!colspan=13|Gambaran Reseptor Serotonin
|-
!rowspan=2| '''Reseptor'''
!rowspan=2| Kloning pertama kali
!rowspan=2| Gen
!colspan=6| Distribusi
!rowspan=2| Fungsi
!rowspan=2| [[Agonis]]
!rowspan=2| [[Antagonis reseptor]]
!rowspan=2| Obat-obat yang beraksi pada reseptor
|-
! [[Pembuluh darah]]
! [[Sistem saraf pusat|SSP]]
! [[Saluran gastrointestinal|Saluran GI]]
! [[Platelet]]
! [[Sistem saraf tepi|PNS]]
! [[Otot polos]]
|-
| '''[[Reseptor 5-HT1A|5-HT<sub>1A</sub>]]'''
|1987
|
* {{Gene|HTR1A}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* Addiksi<ref name="pmid7862892">{{cite journal |vauthors=Tomkins DM, Higgins GA, Sellers EM | title = Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake | journal = Psychopharmacology (Berl). | volume = 115 | issue = 1–2 | pages = 173–9 | year = 1994 | pmid = 7862892 | doi = 10.1007/BF02244769 }}</ref><ref name="pmid17316955">{{cite journal |vauthors=Müller CP, Carey RJ, Huston JP, De Souza Silva MA | title = Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors | journal = Prog Neurobiol. | volume = 81 | issue = 3 | pages = 133–78 | year = 2007 | pmid = 17316955 | doi = 10.1016/j.pneurobio.2007.01.001 }}</ref><ref name="pmid15713268">{{cite journal |vauthors=Carey RJ, DePalma G, Damianopoulos E, Shanahan A, Müller CP, Huston JP | title = Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects | journal = Brain Res. | volume = 1034 | issue = 1–2 | pages = 162–71 | year = 2005 | pmid = 15713268 | doi = 10.1016/j.brainres.2004.12.012 }}</ref>
* Aggresi<ref name="pmid16310183">{{cite journal |vauthors=de Boer SF, Koolhaas JM | title = 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis | journal = Eur J Pharmacol. | volume = 526 | issue = 1–3 | pages = 125–39 | year = 2005 | pmid = 16310183 | doi = 10.1016/j.ejphar.2005.09.065 }}</ref>
* Ansietas<ref name="pmid9724773">{{cite journal |vauthors=Parks CL, Robinson PS, Sibille E, Shenk T, Toth M | title = Increased anxiety of mice lacking the serotonin1A receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 195 | issue = 18 | pages = 10734–9 | year = 1998 | pmid = 9724773 | pmc = 27964 | doi=10.1073/pnas.95.18.10734}}</ref>
* Nafsu makan<ref name="pmid17609739">{{cite journal |vauthors=Ebenezer IS, Arkle MJ, Tite RM | title = 8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors | journal = Methods Find Exp Clin Pharmacol. | volume = 29 | issue = 4 | pages = 269–72 | year = 1998 | pmid = 17609739 | doi = 10.1358/mf.2007.29.4.1075362 }}</ref>
* [[Autoreseptor]]
* Tekanan darah<ref name="pmid2842163">{{cite journal |vauthors=Wouters W, Tulp MT, Bevan P | title = Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors | journal = Eur J Pharmacol. | volume = 149 | issue = 3 | pages = 213–23 | year = 1998 | pmid = 2842163 | doi = 10.1016/0014-2999(88)90651-6 }}</ref><ref name="pmid18667366">{{cite journal |vauthors=Horiuchi J, McDowall LM, Dampney RA | title = Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation | journal = Auton Neurosci. | volume = 142 | issue = 1–2 | pages = 71–6 | year = 2008 | pmid = 18667366 | doi = 10.1016/j.autneu.2008.06.004 }}</ref>
* Fungsi kardiovaskular<ref name="pmid15802554">{{cite journal |vauthors=Nalivaiko E, Ootsuka Y, Blessing WW | title = Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits | journal = Am J Physiol Regul Integr Comp Physiol | volume = 289 | issue = 2 | pages = R596–R604 | year = 2005 | pmid = 15802554 | doi = 10.1152/ajpregu.00845.2004 }}</ref>
* Emesis<ref name="pmid8013549">{{cite journal | author = Lucot JB. | title = Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin | journal = Eur J Pharmacol. | volume = 253 | issue = 1–2 | pages = 53–60 | year = 1994 | pmid = 8013549 | doi = 10.1016/0014-2999(94)90756-0 }}</ref>
* Denyut jantung<ref name="pmid2842163" /><ref name="pmid18667366" />
* Impulsivitas<ref name="pmid15688093">{{cite journal |vauthors=Winstanley CA, Theobald DE, Dalley JW, Robbins TW | title = Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders | journal = Neuropsychopharmacology. | volume = 30 | issue = 4 | pages = 669–682 | year = 2005 | pmid = 15688093 | doi = 10.1038/sj.npp.1300610 }}</ref>
* Memori<ref name="pmid18394726">{{cite journal |vauthors=Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O | title = The role of 5-HT(1A) receptors in learning and memory | journal = Behav. Brain Res. | volume = 195 | issue = 1 | pages = 54–77 | year = 2008 | pmid = 18394726 | doi = 10.1016/j.bbr.2008.02.023 }}</ref><ref name="pmid12562581">{{cite journal |vauthors=Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K | title = Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory | journal = Am J Psychiatry | volume = 160 | issue = 2 | pages = 334–40 | year = 2003 | pmid = 12562581 | doi = 10.1176/appi.ajp.160.2.334 }}</ref>
* Mood<ref name="pmid2883013">{{cite journal |vauthors=Kennett GA, Dourish CT, Curzon G | title = Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression | journal = Eur J Pharmacol. | volume = 134 | issue = 3 | pages = 265–74 | year = 1987 | pmid = 2883013 | doi = 10.1016/0014-2999(87)90357-8 }}</ref>
* Muntah<ref name="pmid8013549" />
* Nosisepsi<ref name="pmid12595749">{{cite journal |vauthors=Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC | title = Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain | journal = Pharmacology. | volume = 67 | issue = 4 | pages = 182–194 | year = 2003 | pmid = 12595749 | doi = 10.1159/000068404 }}</ref>
* Ereksi penis<ref name="pmid9085055">{{cite journal |vauthors=Millan MJ, Perrin-Monneyron S | title = Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors | journal = Eur J Pharmacol. | volume = 321 | issue = 3 | pages = 11–3 | year = 1997 | pmid = 9085055 | doi=10.1016/S0014-2999(97)00050-2}}</ref>
* Dilatasi pupil<ref name="pmid8982715">{{cite journal |vauthors=Prow MR, Martin KF, Heal DJ | title = 8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation | journal = Eur J Pharmacol. | volume = 317 | issue = 1 | pages = 21–8 | year = 1996 | pmid = 8982715 | doi = 10.1016/S0014-2999(96)00693-0 }}</ref>
* Respirasi<ref name="pmid16166206">{{cite journal |vauthors=Meyer LC, Fuller A, Mitchell D | title = Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 290 | issue = 2 | pages = R405–13 |date=February 2006 | pmid = 16166206 | doi = 10.1152/ajpregu.00440.2005 | url = | issn = }}</ref>
* Perilaku seksual<ref name="pmid11965359">{{cite journal |vauthors=Popova NK, Amstislavskaya TG | title = Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice | journal = Psychoneuroendocrinology | volume = 27 | issue = 5 | pages = 609–18 | year = 2002 | pmid = 11965359 | doi = 10.1016/S0306-4530(01)00097-X }}</ref>
* Tidur<ref name="pmid10607047">{{cite journal |vauthors=Monti JM, Jantos H | title = Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat | journal = J Sleep Res. | volume = 1 | issue = 3 | pages = 169–175 | year = 1992 | pmid = 10607047 | doi = 10.1111/j.1365-2869.1992.tb00033.x }}</ref>
* Sosial<ref name="pmid17383105">{{cite journal |vauthors=Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS | title = A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy") | journal = Neuroscience | volume = 146 | issue = 2 | pages = 509–14 | year = 2007 | pmid = 17383105 | doi = 10.1016/j.neuroscience.2007.02.032 }}</ref>
* Thermoregulasi<ref name="pmid2951611">{{cite journal |vauthors=Gudelsky GA, Koenig JI, Meltzer HY | title = Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors | journal = Neuropharmacology | volume = 25 | issue = 12 | pages = 1307–13 | year = 1986 | pmid = 2951611 | doi = 10.1016/0028-3908(86)90101-2 }}</ref>
* Vasokonstriksi<ref name="pmid16455061">{{cite journal |vauthors=Ootsuka Y, Blessing WW | title = Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits | journal = Brain Res. | volume = 1073–1074 | pages = 252–61 | year = 2006 | pmid = 16455061 | doi = 10.1016/j.brainres.2005.12.031 }}</ref>
| <!--5-Agonis HT1A-->
'''<span style="font-size:100%;">Selektif (untuk 5-HT<sub>1A</sub> lebih dari reseptor 5-HT lainnya) </span>'''
* [[Vilazodone]] (Viibryd)
* [[F-15,599]] (senyawa untuk riset, sangat poten dan selektif untuk 5-HT<sub>1A</sub>)
* [[Flesinoxan]] (poten, EC<sub>50</sub> = 24 nM)
* [[Gepirone]] ([[agonis parsial]], K<sub>i</sub> = 70 nM)
* [[Haloperidol]]
* [[Ipsapirone]] (agonis parsial, K<sub>i</sub> = 12.1 nM)
* [[Quetiapine]]
* [[Trazodone]] ([[Serotonin antagonist and reuptake inhibitor|SARI]] K<sub>d</sub> = 78nM)
* [[Yohimbine]] (agonis parsial tidak selektif)
* [[Tandospirone]] (agonis parsial dan selektif)
'''<span style="font-size:100%;"> Nonselektif </span>'''
* [[5-Carboxamidotryptamine|5-CT]] (poten – K<sub>i</sub> = 250±50 pM)
* [[8-OH-DPAT]] (poten)
* [[Aripiprazole]] ([[antipsikotik atipikal]])
* [[Asenapine]] ([[antipsikotik atipikal]])
* [[Buspirone]]<ref name=pharmamotion>[http://pharmacologycorner.com/serotonin-5ht-receptors-agonists-antagonist/ Pharmacology Corner > Serotonin (5-HT): receptors, agonists and antagonists] By Flavio Guzmán, M.D. on 9/08/09</ref> (agonis parsial)
* [[Vortioxetine]] (agonis parsial efikasi tinggi)<ref name="vortioxetine">"BRINTELLIX™ (vortioxetine) tablets for oral use. Full Prescribing Information, Section 12.2 (Pharmacodynamics)." Takeda Pharmaceuticals America Inc. and Lundbeck, 2013. Revised September 2013. [http://general.takedapharm.com/content/file/pi.pdf?applicationcode=396066C6-E50F-4113-ABAD-54FE9525BF7E&filetypecode=BRINTELLIXPI] {{Webarchive|url=https://web.archive.org/web/20190918205248/http://general.takedapharm.com/content/file/pi.pdf?applicationcode=396066C6-E50F-4113-ABAD-54FE9525BF7E&filetypecode=BRINTELLIXPI |date=2019-09-18 }}</ref>
* [[Ziprasidone]] (agonis parsial, K<sub>i</sub> = 3.4 nM)
|<!--5-HT1A ANTAGONIS-->
* [[BMY 7378]]
* [[Cyanopindolol]]
* [[Iodocyanopindolol]]
* [[Lecozotan]]
* [[Methiothepin]]
* [[Methysergide]]<ref>{{cite journal|last=Saxena|first=PR|author2=Lawang, A|title=A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.|journal=Archives Internationales de Pharmacodynamie et de Thérapie|date=Oct 1985|volume=277|issue=2|pages=235–52|pmid=2933009}}</ref>
* [[NAN-190]]
* [[Nebivolol]]
* [[Nefazodone]]
* [[WAY-100,135]]
* [[WAY-100,635]]
* [[Mefway]]
|
* [[Analgesik]] (agonis)
* [[Antidepresan]] (agonis reseptor post-sinaptik dan antagonis [[autoreseptor]] pre-sinaptik sebagai antidepresan)
* [[Ansiolitik]]<ref name="pmid9784072">{{cite journal |vauthors=Cao BJ, Rodgers RJ |title=Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice |journal=Psychopharmacology |volume=139 |issue=3 |pages=185–94 |date=October 1998 |pmid=9784072 |doi= 10.1007/s002130050703|url=}}</ref> (antagonist)
|-
| '''[[5-HT1B receptor|5-HT<sub>1B</sub>]]'''
|1992
|
* {{Gene|HTR1B}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* Addiksi<ref name="pmid10027505">{{cite journal |vauthors=Harrison AA, Parsons LH, Koob GF, Markou A | title = RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist | journal = Psychopharmacology (Berl). | volume = 141 | issue = 3 | pages = 242–50 | year = 1999 | pmid = 10027505 | doi = 10.1007/s002130050831 }}</ref>
* Aggressi<ref name="pmid16310183" />
* Ansietas<ref name="pmid15720791">{{cite journal |vauthors=Chojnacka-Wójcik E, Klodzinska A, Tatarczynska E | title = The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action | journal = J Pharm Pharmacol. | volume = 57 | issue = 2 | pages = 253–7 | year = 2005 | pmid = 15720791 | doi = 10.1211/0022357055399 }}</ref><ref name="pmid11888549">{{cite journal |vauthors=Lin D, Parsons LH | title = Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze | journal = Pharmacol Biochem Behav. | volume = 71 | issue = 4 | pages = 581–7 | year = 2002 | pmid = 11888549 | doi = 10.1016/S0091-3057(01)00712-2 }}</ref><ref name="pmid15577451">{{cite journal |vauthors=Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E | title = Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression | journal = Behav Pharmacol. | volume = 15 | issue = 8 | pages = 523–34 | year = 2004 | pmid = 15577451 | doi = 10.1097/00008877-200412000-00001 }}</ref>
* [[Autoreseptor]]
* Belajar<ref name="pmid18394658">{{cite journal |vauthors=Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO | title = Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission | journal = Neuropharmacology | volume = 54 | issue = 7 | pages = 1041–50 | year = 2008 | pmid = 18394658 | doi = 10.1016/j.neuropharm.2008.02.007 }}</ref>
* Lokomosi<ref name="pmid10454466">{{cite journal |vauthors=McCreary AC, Bankson MG, Cunningham KA | title = Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors | journal = J Pharmacol Exp Ther. | volume = 290 | issue = 3 | pages = 965–73 | year = 1999 | pmid = 10454466 }}</ref>
* Memori<ref name="pmid18394658" />
* Mood<ref name="pmid15577451" />
* Ereksi penis<ref name="pmid9085055" />
* Perilaku seksual<ref name="pmid11965359" />
* Vasokonstriksi
|<!--5-HT1B AGONIS-->
* [[5-Carboxamidotryptamine|5-CT]]
* [[CGS-12066A]]
* [[CP-93,129]]
* [[CP-94,253]]
* [[Dihydroergotamine]]
* [[Eltoprazine]]
* [[Ergotamine]]
* [[Methysergide]]
* [[RU 24969]]
* [[TFMPP]]
* [[Triptans]]<ref name=pharmamotion /> ([[antimigraine]]<ref name=pharmamotion />)
** [[Zolmitriptan]]
** [[Eletriptan]]
** [[Sumatriptan]]
* [[Vortioxetine]] (partial agonist, K<sub>i</sub> = 33 nM)<ref name="vortioxetine" />
|<!--5-HT1B ANTAGONIS-->
* [[Alprenolol]]
* [[AR-A000002]]
* [[Asenapine]]
* [[Cyanopindolol]]
* [[GR-127,935]]
* [[Iodocyanopindolol]]
* [[Isamoltane]]
* [[Metergoline]]
* [[Methiothepin]]
* [[Oxprenolol]]
* [[Pindolol]]
* [[Propranolol]]
* [[SB-216,641]]
* [[Yohimbine]]
|
* [[Migrain]] (e.g. [[triptans]])
|-
| '''[[Reseptor 5-HT1D|5-HT<sub>1D</sub>]]'''
|1991
|
* {{Gene|HTR1D}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* Ansietas<ref name="pmid15820416">{{cite journal |vauthors=Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J | title = Anxiogenic effects of Sumatriptan in panic disorder: a double-blind, placebo-controlled study | journal = Eur Neuropsychopharmacol. | volume = 15 | issue = 3 | pages = 279–82 | year = 2005 | pmid = 15820416 | doi = 10.1016/j.euroneuro.2004.12.002 }}</ref><ref name="pmid8736648">{{cite journal |vauthors=Feuerstein TJ, Hüring H, van Velthoven V, Lücking CH, Landwehrmeyer GB | title = 5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex | journal = Neurosci Lett. | volume =209 | issue = 3 | pages = 210–4 | year = 1996 | pmid = 8736648 | doi = 10.1016/0304-3940(96)12637-9 }}</ref>
* [[Autoreseptor]]
* Lokomosi<ref name="pmid10454466" />
* Vasokonstriksi
|<!--5-HT1D AGONIS-->
* [[5-Carboxamidotryptamine|5-CT]]
* [[CP-135,807]]
* [[Dihydroergotamine]]
* [[Ergotamine]]
* [[Methysergide]]
* [[Triptans]]<ref name=pharmamotion /> ([[antimigrain]]<ref name=pharmamotion />)
** [[Almotriptan]]
** [[Eletriptan]]
** [[Frovatriptan]]
** [[Naratriptan]]
** [[Rizatriptan]]
** [[Sumatriptan]]
** [[Zolmitriptan]]
* [[Yohimbine]]
|<!--5-HT1D ANTAGONIS-->
* [[BRL-15572]]
* [[GR-127,935]]
* [[Ketanserin]]
* [[Metergoline]]
* [[Methiothepin]]
* [[Rauwolscine]]
* [[Ritanserin]]
* [[Vortioxetine]] (K<sub>i</sub> = 54 nM)<ref name="vortioxetine" />
* [[Ziprasidone]]
|
* [[Migrain]] (e.g. [[triptans]])
|-
| '''[[5-HT1E|5-HT<sub>1E</sub>]]'''
|1992
|
* {{Gene|HTR1E}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
|
* [[BRL-54443]]
|
|
* Tidak diketahui
|-
| '''[[5-HT1F|5-HT<sub>1F</sub>]]'''
|1993
|
* {{Gene|HTR1F}}
| {{Tidak}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* Migrain
|<!--5-HT1F AGONIS-->
* [[BRL-54443]]
* [[Lasmiditan]]
* [[LY-334,370]]
* [[Naratriptan]]
|
|
* Tidak diketahui
|-
| '''[[Reseptor 5-HT2A|5-HT<sub>2A</sub>]]'''
|1988
|
* {{Gene|HTR2A}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
|
* Addiksi (modulasi secara potensial)<ref name="Bubar">[http://www.ncbi.nlm.nih.gov/pubmed/17017968] Bubar MJ, Cunningham KA. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem. 2006;6(18):1971-85.</ref>
* Ansietas<ref name="pmid9539263">{{cite journal |vauthors=Schreiber R, Melon C, De Vry J | title = The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test | journal = Psychopharmacology (Berl). | volume = 135 | issue = 4 | pages = 383–91 | year = 1998 | pmid = 9539263 | doi = 10.1007/s002130050526 }}</ref>
* Nafsu makan
* Kognisi
* Imajinasi
* Belajar
* Memori
* Mood
* Persepsi
* Perilaku seksual<ref name="pmid12097814">{{cite journal |vauthors=Popova NK, Amstislavskaya TG | title = 5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female | journal = Neuroendocrinology | volume = 76 | issue = 1 | pages = 28–34 | year = 2002 | pmid = 12097814 | doi = 10.1159/000063681 }}</ref>
* Tidur<ref name="pmid16339018">{{cite journal |vauthors=Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J | title = Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors | journal = J Neurosci. | volume = 25 | issue = 49 | pages = 11231–8 | year = 2005 | pmid = 16339018 | doi = 10.1523/JNEUROSCI.1724-05.2005 }}</ref>
* Thermoregulasi<ref name="pmid9106912">{{cite journal |vauthors=Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL | title = Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists| journal = Psychopharmacology (Berl). | volume = 130 | issue = 2 | pages = 144–51 | year = 1997 | pmid = 9106912 | doi = 10.1007/s002130050222 }}</ref>
* Vasokonstriksi<ref name="pmid12654345">{{cite journal |vauthors=Blessing WW, Seaman B | title = 5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats | journal = Neuroscience. | volume = 117 | issue = 4 | pages = 939–948 | year = 2003 | pmid = 12654345 | doi = 10.1016/S0306-4522(02)00810-2 }}</ref>
|<!--5-HT2A AGONIS-->
* [[25I-NBOMe]] (agonis penuh)
* [[2C-B]]
* [[5-MeO-DMT]]
* [[Benzylpiperazine|BZP]]
* [[Bufotenin]]
* [[Dimethyltryptamine|DMT]]
* [[2,5-Dimethoxy-4-methylamphetamine|DOM]]
* [[Ergonovine]]
* [[Lisuride]]
* [[LSD]]
* [[Mescaline]]
* [[Myristicin]]
* [[PNU-22394]] (agonis parsial)<ref name="McCall2001">{{cite journal |author1= McCall, R. B. |author2= Franklin, S. R. |author3= Hyslop, D. K. |author4= Knauer, C. S. |author5= Chio, C. L. |author6= Haber, C. L. |author7= Fitzgerald, L. W. |title= PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans |date= 2001 |conference= Society for Neuroscience |others= Presentation Number 309.2 | volume = 27 | issue = 309.2 |publisher= Society for Neuroscience Abstracts |url= http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Detail?AbsYear=2001&AbsID=4715 |location= Convention Center Exhibit Hall, Poster Board TT-45, San Diego, CA |format= Online |accessdate= 18 July 2014}}</ref><ref name="pmid19029184">{{cite journal |vauthors=Garfield AS, Heisler LK | title = Pharmacological targeting of the serotonergic system for the treatment of obesity | journal = The Journal of Physiology | year = 2009 | volume = 587 | issue = 1 | pages = 49–60 | doi = 10.1113/jphysiol.2008.164152 | pmc = 2670022 | pmid=19029184}}</ref><ref name="Jensen2013">{{cite journal | author1 = Jensen, Anders A. | author2 = Plath, Niels | author3 = Pedersen, Martin Holst Friborg | author4 = Isberg, Vignir | author5 = Krall, Jacob | author6 = Wellendorph, Petrine | author7 = Stensbøl, Tine B. | author8 = Gloriam, David E. | author9 = Krogsgaard-Larsen, Povl | author10 = Frølund, Bente | display-authors = 4 | title = Design, Synthesis, and Pharmacological Characterization of N- and O-Substituted 5,6,7,8-Tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol Analogues: Novel 5-HT2A/5-HT2C Receptor Agonists with Pro-Cognitive Properties | journal = Journal of Medicinal Chemistry | year = 2013 | volume = 56 | issue = 3 | pages = 1211–1227 | doi = 10.1021/jm301656h | issn = 0022-2623}}</ref>
* [[Psilocin]]
* [[Psilocybin]]
* [[TFMPP]] (agonis parsial atau antagonis)
|<!--5-HT2A ANTAGONIS-->
* [[antipsikotik atipikal]]
** [[Clozapine]]<ref name=pharmamotion />
** [[Olanzapine]]
** [[Quetiapine]]
** [[Risperidone]]
** [[Ziprasidone]]
* [[Aripiprazole]]
* [[Asenapine]]
* [[Amitriptyline]]
* [[Clomipramine]]
* [[Cyproheptadine]]
* [[Eplivanserin]]
* [[Etoperidone]]
* [[Haloperidol]]
* [[Hydroxyzine]]
* [[Iloperidone]]
* [[Ketanserin]]<ref name=pharmamotion /> ([[antihypertensive]]<ref name=pharmamotion />)
* [[Methysergide]]
* [[Mianserin]]
* [[Mirtazapine]]
* [[Nefazodone]]
* [[Pimavanserin]]
* [[Pizotifen]]
* [[Ritanserin]]
* [[Trazodone]]
* [[Yohimbine]]
|
* [[Antipsikotik atipikal]] (antagonis)
* [[Psychedelics]] (agonis parsial)
* [[NaSSA]]s (antidepresan dan ansiolitik; mereka beraksi sebagai antagois pada situs ini)
* Pengobatan [[sindrom serotonin]] (antagonis; misal [[siproheptadin]])
* Membantu tidur (antagonis; misal trazodone)
|-
| '''[[Reseptor 5-HT2B|5-HT<sub>2B</sub>]]'''
|1992
|
* {{Gene|HTR2B}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
|
* Ansietas<ref name="pmid8730737">{{cite journal |vauthors=Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP | title = Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety | journal = Br J Pharmacol. | volume = 117 | issue = 7 | pages = 1443–8 | year = 1996 | pmid = 8730737 | pmc = 1909458 | doi=10.1111/j.1476-5381.1996.tb15304.x}}</ref><ref name="pmid9225285">{{cite journal |vauthors=Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC | title = Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 601–8 | year = 1997 | pmid = 9225285 | doi = 10.1016/S0028-3908(97)00042-7 }}</ref><ref name="pmid9886683">{{cite journal |vauthors=Kennett GA, Trail B, Bright F | title = Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated | journal = Neuropharmacology | volume = 37 | issue = 12 | pages = 1603–10 | year = 1998 | pmid = 9886683 | doi = 10.1016/S0028-3908(98)00115-4 }}</ref>
* Nafsu makan<ref name="pmid9144661">{{cite journal |vauthors=Kennett GA, Ainsworth K, Trail B, Blackburn TP | title = BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats | journal = Neuropharmacology | volume = 36 | issue = 2 | pages = 233–9 | year = 1997 | pmid = 9144661 | doi = 10.1016/S0028-3908(96)00171-2 }}</ref>
* Fungsi kardiovaskular
* Motilitas GI<ref name="pmid11877320">{{cite journal |vauthors=Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS | title = 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro | journal = Br J Pharmacol. | volume = 135 | issue = 5 | pages = 1144–1151 | year = 2002 | pmid = 11877320 | doi = 10.1038/sj.bjp.0704571 | pmc = 1573235 }}</ref>
* Tidur<ref name="pmid16339018" />
* Vasokonstriksi
|<!--5-HT2B AGONIS-->
* [[BW-723C86]]
* [[Fenfluramine]]
* [[MDMA]]
* [[Norfenfluramine]]
* [[PNU-22394]] (agonis parsial)<ref name="McCall2001" /><ref name="pmid19029184" /><ref name="Jensen2013" />
* [[Ro60-0175]]
|<!--5-HT2B ANTAGONIS-->
* [[Agomelatine]]
* [[Asenapine]]
* [[Benzylpiperazine|BZP]]
* [[Ketanserin]]
* [[Methysergide]]
* [[Ritanserin]]
* [[RS-127,445]]
* [[Tegaserod]]
* [[Yohimbine]]
|
* [[Migrain]] (antagonis)
|-
| '''[[Reseptor 5-HT2C|5-HT<sub>2C</sub>]]'''
|1988
|
* {{Gene|HTR2C}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
|
* Addiksi. (modulasi secara potensial)<ref name="Bubar" />
* Ansietas<ref name="pmid9225286">{{cite journal |vauthors=Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP | title = SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist | journal = Neuropharmacology. | volume = 36 | issue = 4–5 | pages = 609–20 | year = 1997 | pmid = 9225286 | doi = 10.1016/S0028-3908(97)00038-5 }}</ref><ref name="pmid15289999">{{cite journal |vauthors=Millan MJ, Brocco M, Gobert A, Dekeyne A | title = Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade | journal = Psychopharmacology (Berl). | volume = 177 | issue = 4 | pages = 448–58 | year = 2005 | pmid = 15289999 | doi = 10.1007/s00213-004-1962-z }}</ref><ref name="pmid18523738">{{cite journal |vauthors=Millan MJ, Brocco M, Gobert A, Dekeyne A | title = S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models | journal = Psychopharmacology (Berl). | volume = 199 | issue = 4 | pages = 549–68 | year = 2008 | pmid = 18523738 | doi = 10.1007/s00213-008-1177-9 }}</ref>
* Nafsu makan
* Motilitas GI<ref name="pmid19058784">{{cite journal |vauthors=Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A | title = Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin | journal = Biol Psychiatry. | volume = 65 | issue = 9 | pages = 748–759 | year = 2009 | pmid = 19058784 | doi = 10.1016/j.biopsych.2008.10.031 }}</ref>
* [[Heteroreceptor]] for [[norepinephrine]] and [[dopamine]]
* Lokomosi
* Mood<ref name="pmid15289999" /><ref name="pmid18523738" />
* Ereksi penis<ref name="pmid9151932">{{cite journal |vauthors=Millan MJ, Peglion JL, Lavielle G, Perrin-Monneyron S | title = 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists | journal = Eur J Pharmacol. | volume = 325 | issue = 1 | pages = 9–12 | year = 1997 | pmid = 9151932 | doi = 10.1016/S0014-2999(97)89962-1 }}</ref><ref name="pmid8001637">{{cite journal |vauthors=Stancampiano R, Melis MR, Argiolas A | title = Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission | journal = Eur J Pharmacol. | volume = 261 | issue = 1–2 | pages = 149–55 | year = 1994 | pmid = 8001637 | doi = 10.1016/0014-2999(94)90313-1 }}</ref>
* Perilaku seksual<ref name="pmid12097814" />
* Tidur<ref name="pmid12431861">{{cite journal |vauthors=Frank MG, Stryker MP, Tecott LH | title = Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor | journal = Neuropsychopharmacology | volume = 27 | issue = 5 | pages = 869–73 | year = 2002 | pmid = 12431861 | doi = 10.1016/S0893-133X(02)00353-6 | pmc = 2452994 }}</ref>
* Thermoregulasi<ref name="pmid9106912" />
* Vasokonstriksi
|<!--5-HT2C AGONIS-->
* [[A-372,159]]
* [[AL-38022A]]
* [[Aripiprazole]]
* [[Ergonovine]]
* [[Lorcaserin]]
* [[PNU-22394]] (agonis penuh)<ref name="McCall2001" /><ref name="pmid19029184" /><ref name="Jensen2013" />
* [[Ro60-0175]]
* [[TFMPP]]
* [[Trazodone]]<ref name=pharmamotion /> ([[hypnotic]]<ref name=pharmamotion />)
* [[YM-348]]
|<!--5-HT2C ANTAGONIS-->
* [[Agomelatine]]<ref name=pharmamotion /> ([[antidepressant]]<ref name=pharmamotion />)
* [[Amitriptyline]]
* [[Asenapine]]
* [[Klomipramin]]
* [[Klozapin]]<ref name=pharmamotion /> ([[antipsychotic]]<ref name=pharmamotion />)
* [[Siproheptadine]]
* [[Dimebolin]]
* [[Eltoprazine]]
* [[Etoperidone]]
* [[Fluoksetin]]
* [[Haloperidol]]
* [[Iloperidone]]
* [[Ketanserin]]<ref name=pharmamotion /> ([[antihypertensive]]<ref name=pharmamotion />)
* [[Lisuride]]
* [[Methysergide]]<ref name=Rang187>{{cite book |author=Rang, H. P. |title=Pharmacology |url=https://archive.org/details/isbn_9788181479174 |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages= |isbn=0-443-07145-4 |oclc= |doi=}} Page 187</ref>
* [[Mianserin]]
* [[Mirtazapin]]
* [[Nefazodon]]
* [[Olanzapin]]
* [[Paroksetin]]
* [[Quetiapine]]
* [[Risperidon]]
* [[Ritanserin]]
* [[Tramadol]]
* [[Trazodone]]
* [[Ziprasidone]]
|
* [[Antidepresan]] (misal [[agomelatin]], [[fluoksetin]], [[mirtazapin]])
* [[Oreksigenik]] (misal mirtazapin, klozapin and olanzapin; antagonis)
* [[Anorektik]] (Lorcaserin)
* [[Antipsikotik]] (Vabicaserin; agonis)
|-
| '''[[Reseptor 5-HT3|5-HT<sub>3</sub>]]'''
|1993
|
* {{Gene|HTR3A}}
* {{Gene|HTR3B}}
* {{Gene|HTR3C}}
* {{Gene|HTR3D}}
* {{Gene|HTR3E}}
| {{Tidak}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Ya}}
| {{Tidak}}
|
* Addiksi
* Asietas
* Emesis
* Motilitas GI<ref>{{cite web|title=Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors.|url=http://www.ncbi.nlm.nih.gov/pubmed?cmd=historysearch&querykey=1|vauthors=Michel K, Zeller F, Langer R, Nekarda H, Kruger D, Dover TJ, Brady CA, Barnes NM, Schemann M |publisher=National Center for Biotechnology Information|accessdate=10 October 2014|date=May 2005}}</ref>
* Belajar<ref name="pmid8115433">{{cite journal |vauthors=Pitsikas N, Brambilla A, Borsini F | title = Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task | journal = Pharmacol Biochem Behav. | volume = 47 | issue = 1 | pages = 95–99 | year = 1994 | pmid = 8115433 | doi = 10.1016/0091-3057(94)90116-3 }}</ref>
* Memori<ref name="pmid8115433" />
* Muntah
|<!--5-HT3 AGONIS-->
* [[2-methyl-5-hydroxytryptamine|2-Methyl-5-HT]]
* [[Benzylpiperazine|BZP]]
* [[Quipazine]]
* [[RS-56812]]
|<!--5-HT3 ANTAGONIS-->
* [[Alosetron]]
* Beberapa [[antimuntah]]<ref name=pharmamotion />
** [[Dolasetron]]
** [[Ondansetron]]<ref name=pharmamotion />
** [[Granisetron]]
** [[Tropisetron]]
* [[Klozapin]]
* [[Memantin]]
* [[Metoklopramid]]
* [[Mianserin]]
* [[Mirtazapin]]
* [[Olanzapin]]
* [[Quetiapine]]
* [[Vortioxetine]] (K<sub>i</sub> = 3.7 nM)<ref name="vortioxetine" />
|
* [[Antimuntah]]
|-
| '''[[Reseptor 5-HT4|5-HT<sub>4</sub>]]'''
|1995
|
* {{Gene|HTR4}}
| {{Tidak}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Ya}}
| {{Tidak}}
|
* Ansietas<ref name="pmid14676321">{{cite journal |vauthors=Smriga M, Torii K | title = L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 26 | pages = 15370–5 | year = 2003 | pmid = 14676321 | doi = 10.1073/pnas.2436556100 | pmc = 307574 }}</ref><ref name="pmid9225297">{{cite journal |vauthors=Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ | title = Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 707–12 | year = 1997 | pmid = 9225297 | doi = 10.1016/S0028-3908(97)00037-3 }}</ref>
* Nafsu makan<ref name="pmid17913892">{{cite journal |vauthors=Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V | title = Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 41 | pages = 16335–40 | year = 2007 | pmid = 17913892 | doi = 10.1073/pnas.0701471104 | pmc = 2042207 }}</ref><ref name="pmid15146954">{{cite journal | title = Feeding disorders in 5-HT4 receptor knockout mice | journal = J Soc Biol. | volume = 198 | issue = 1 | pages = 37–49 | year = 2004 | pmid = 15146954 |author1=Compan V | last2 = Charnay | first2 = Y | last3 = Dusticier | first3 = N | last4 = Daszuta | first4 = A | last5 = Hen | first5 = R | last6 = Bockaert | first6 = J }}</ref>
* Motilitas GI
* Belajar<ref name="Meneses A, Hong E 1997 347–51">{{cite journal |vauthors=Meneses A, Hong E |title=Effects of 5-HT4 receptor agonists and antagonists in learning |journal=Pharmacol Biochem Behav |volume=56 |issue=3 |pages=347–51 |year=1997 |pmid=9077568 |doi=10.1016/S0091-3057(96)00224-9}}</ref><ref name="pmid9225295">{{cite journal |vauthors=Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 689–96 | year = 1997 | pmid = 9225295 | doi = 10.1016/S0028-3908(97)00055-5 }}</ref>
* Memori<ref name="Meneses A, Hong E 1997 347–51" /><ref name="pmid9225295" /><ref name="pmid9732367">{{cite journal |vauthors=Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = Role of 5-HT4 receptors in the mouse passive avoidance test | journal = J Pharmacol Exp Ther. | volume = 286 | issue = 3 | pages = 1115–21 | year = 1998 | pmid = 9732367 }}</ref>
* Mood<ref name="pmid17785179">{{Cite journal | last1 = Lucas | first1 = G. | last2 = Rymar | first2 = V. V. | last3 = Du | first3 = J. | last4 = Mnie-Filali | first4 = O. | last5 = Bisgaard | first5 = C. | last6 = Manta | first6 = S. | last7 = Lambas-Senas | first7 = L. | last8 = Wiborg | first8 = O. | last9 = Haddjeri | first9 = N. | last10 = Piñeyro | first10 = G. | last11 = Sadikot | first11 = A. F. | last12 = Debonnel | first12 = G. | doi = 10.1016/j.neuron.2007.07.041 | title = Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action | journal = Neuron | volume = 55 | issue = 5 | pages = 712–725 | year = 2007 | pmid = 17785179| pmc = }}</ref><ref name="pmid17785173">{{Cite journal | last1 = Duman | first1 = R. S. | title = A Silver Bullet for the Treatment of Depression? | doi = 10.1016/j.neuron.2007.08.011 | journal = Neuron | volume = 55 | issue = 5 | pages = 679–681 | year = 2007 | pmid = 17785173| pmc = }}</ref>
* Respirasi<ref name="Manzke2003">{{cite journal|last1=Manzke|first1=T.|title=5-HT4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia|journal=Science|volume=301|issue=5630|year=2003|pages=226–229|issn=0036-8075|doi=10.1126/science.1084674|pmid=12855812}}</ref>
|<!--5-HT4 AGONIS-->
* [[5-Methoxytryptamine|5-MT]]
* [[BIMU-8]]
* [[Cinitapride]]
* [[Cisaprid]]<ref name=pharmamotion /> ([[agen prokinetik|gastroprokinetik]])
* [[Dazopride]]
* [[Metoklopramid]]
* [[Mosaprid]]
* [[Prucalopride]]
* [[RS-67333]]
* [[Renzapride]]
* [[Tegaserod]]
* [[Zacopride]]
|<!--5-HT4 ANTAGONIS-->
* [[L-Lysine]]<ref name="pmid14676321" />
* [[Piboserod]]
|
* [[Agen prokinetik|Gastroprokinetik]] (misal Tegaserod)
|-
| '''[[Reseptor 5-HT5A|5-HT<sub>5A</sub>]]'''
|1994
|
* {{Gene|HTR5A}}
| {{Tidak}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* [[Autoreseptor]]
* Lokomosi<ref name="pmid14965244">{{cite journal | author = Nelson DL | title = 5-HT5 receptors | journal = Curr Drug Targets CNS Neurol Disord. | volume =3 | issue = 1 | pages = 53–8 | year = 2004 | pmid = 14965244 | doi = 10.2174/1568007043482606 }}</ref>
* Tidur<ref name="pmid15921820">{{cite journal |vauthors=Dietz BM, Mahady GB, Pauli GF, Farnsworth NR | title = Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro | journal = Brain Res Mol Brain Res. | volume = 138 | issue = 2 | pages = 191–7 | year = 2005 | pmid = 15921820 | doi = 10.1016/j.molbrainres.2005.04.009 }}</ref>
|<!--5-HT5A AGONIS-->
* [[5-Carboxamidotryptamine|5-CT]]
* [[Ergotamine]]
* [[Valerenic acid|Valerenic Acid]] (partial agonist)<ref name="pmid15921820" />
|<!--5-HT5A ANTAGONISTs-->
* [[Asenapine]]
* [[Dimebolin]]
* [[Methiothepin]]
* [[Ritanserin]]
* [[SB-699,551]]
* [[SB-699,551-A]]
|
* Tidak ada selama ini
|-
| '''[[Reseptor 5-HT5B|5-HT<sub>5B</sub>]]'''
|1993
|
* {{Gene|HTR5BP}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
<small>Functions in rodents,<br />[[pseudogene]] in humans</small>
|
|
|
* tidak ada selama ini
|-
| '''[[Reseptor 5-HT6|5-HT<sub>6</sub>]]'''
|1993
|
* {{Gene|HTR6}}
| {{Tidak}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* Ansietas<ref name="pmid18096153">{{cite journal | author = Wesolowska A | title = The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors | journal = European Journal of Pharmacology | volume = 580 | issue = 3 | pages = 355–60 |date=February 2008 | pmid = 18096153 | doi = 10.1016/j.ejphar.2007.11.022 | url = | issn = }}</ref><ref name="pmid17320917">{{cite journal |vauthors=Wesolowska A, Nikiforuk A | title = Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression | journal = Neuropharmacology | volume = 52 | issue = 5 | pages = 1274–83 |date=April 2007 | pmid = 17320917 | doi = 10.1016/j.neuropharm.2007.01.007 | url = | issn = }}</ref>
* Kognisi<ref name="pmid17069795">{{cite journal |vauthors=Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N | title = SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models | journal = European Journal of Pharmacology | volume = 553 | issue = 1–3 | pages = 109–19 |date=December 2006 | pmid = 17069795 | doi = 10.1016/j.ejphar.2006.09.049 | url = | issn = }}</ref>
* Belajar<ref name="pmid15964617">{{cite journal |vauthors=Perez-García G, Meneses A | title = Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task | journal = Pharmacology, Biochemistry, and Behavior | volume = 81 | issue = 3 | pages = 673–82 |date=July 2005 | pmid = 15964617 | doi = 10.1016/j.pbb.2005.05.005 | url = | issn = }}</ref>
* Memori<ref name="pmid15964617" />
* Mood<ref name="pmid17320917" /><ref name="pmid18234190">{{cite journal |vauthors=Wesolowska A, Nikiforuk A | title = The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats | journal = European Journal of Pharmacology | volume = 582 | issue = 1–3 | pages = 88–93 |date=March 2008 | pmid = 18234190 | doi = 10.1016/j.ejphar.2007.12.013 | url = | issn = }}</ref>
|<!--5-HT6 AGONIS-->
* [[EMD-386,088]]
* [[2-Ethyl-5-methoxy-N,N-dimethyltryptamine|EMDT]]
|<!--5-HT6 ANTAGONIS-->
* [[Amitriptilin]]
* [[Aripiprazol]]
* [[Asenapin]]
* [[Klomipramine]]
* [[Klozapin]]
* [[Dimebolin]]
* [[EGIS-12233]]
* [[Haloperidol]]
* [[Iloperidone]]
* [[MS-245]]
* [[Olanzapin]]
* [[Ro04-6790]]
* [[SB-258,585]]
* [[SB-271,046]]<ref name="titleTarget Schizophrenia – Possible future developments">{{cite web|url=http://www.abpi.org.uk/publications/publication_details/targetSchizophrenia-2003/section5.asp |title=Target Schizophrenia – Possible future developments |accessdate=2008-04-11 |date= |format= |work= |publisher=The Association of the British Pharmaceutical Industry |pages= |language= |archiveurl=https://web.archive.org/web/20080612135635/http://www.abpi.org.uk/publications/publication_details/targetSchizophrenia-2003/section5.asp |archivedate=2008-06-12 |quote= |deadurl=no |df= }}</ref>
* [[SB-357,134]]
* [[SB-399,885]]
|
* [[Antidepressant]] (antagonis dan agonis)
* [[Anxiolytic]] (antagonis dan agonis)
* [[Nootropic]] (antagonis)
* [[Anorectic]] (antagonis)
|-
| '''[[Reseptor 5-HT7|5-HT<sub>7</sub>]]'''
|1993
|
* {{Gene|HTR7}}
| {{Ya}}
| {{Ya}}
| {{Ya}}
| {{Tidak}}
| {{Tidak}}
| {{Tidak}}
|
* Ansietas<ref name="pmid16018977">{{cite journal |vauthors=Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG | title = 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern | journal = Biological Psychiatry | volume = 58 | issue = 10 | pages = 831–7 |date=November 2005 | pmid = 16018977 | doi = 10.1016/j.biopsych.2005.05.012 | url = | issn = }}</ref><ref name="pmid16828124">{{cite journal |vauthors=Wesolowska A, Nikiforuk A, Stachowicz K, Tatarczynska E | title = Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression | journal = Neuropharmacology | volume = 51 | issue = 3 | pages = 578–86 |date=September 2006 | pmid = 16828124 | doi = 10.1016/j.neuropharm.2006.04.017 | url = | issn = }}</ref>
* [[Autoreseptor]]
* Memori<ref name="pmid18308404">{{cite journal |vauthors=Gasbarri A, Cifariello A, Pompili A, Meneses A | title = Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat | journal = Behavioural Brain Research | volume = 195 | issue = 1 | pages = 164–70 |date=December 2008 | pmid = 18308404 | doi = 10.1016/j.bbr.2007.12.020 | url = | issn = }}</ref><ref name="pmid18570192">{{cite journal |vauthors=Liy-Salmeron G, Meneses A | title = Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model | journal = Hippocampus | volume = 18 | issue = 9 | pages = 965–74 | year = 2008 | pmid = 18570192 | doi = 10.1002/hipo.20459 | url = | issn = }}</ref>
* Mood<ref name="pmid16018977" /><ref name="pmid16828124" />
* Respirasi<ref name="pmid16166206" /><ref name="pmid17314195">{{cite journal |vauthors=Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C | title = Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents | journal = J Pharmacol Exp Ther. | volume = 321 | issue = 2 | pages = 690–8 | year = 2007 | pmid = 17314195 | doi = 10.1124/jpet.107.119404 }}</ref>
* Sleep<ref name="pmid16018977" /><ref name="pmid17314195" /><ref name="pmid12812993">{{cite journal |vauthors=Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT | title = SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats | journal = Br J Pharmacol. | volume = 139 | issue = 4 | pages = 705–14 | year = 2003 | pmid = 12812993 | doi = 10.1038/sj.bjp.0705290 | pmc = 1573887 }}</ref>
* Thermoregulasi
* Vasokonstriksi
|<!--5-HT7 AGONIS-->
* [[5-Carboxamidotryptamine|5-CT]]
* [[8-OH-DPAT]]
* [[Aripiprazol]] ([[agonis parsial]] lemah)<ref>Davies MA, Sheffler DJ, Roth BL. Aripiprazole: A Novel Atypical Antipsychotic Drug With a Uniquely Robust Pharmacology. CNS Drug Reviews [Internet]. 2004 [cited 2013 Aug 4];10(4):317–36. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2004.tb00030.x/pdf</ref>
* [[AS-19 (drug)|AS-19]]
* [[E-55888]]
* [[1-(2-Diphenyl)piperazine|RA-7]]
|<!--5-HT7 ANTAGONIS-->
* [[Amitriptilin]]
* [[Asenapin]]
* [[Klomipramin]]
* [[Klozapin]]
* [[EGIS-12233]]
* [[Haloperidol]]
* [[Iloperidon]]
* [[Imipramin]]
* [[Ketanserin]]
* [[Mirtazapin]]
* [[Olanzapin]]
* [[Ritanserin]]
* [[Risperidon]]
* [[SB-269,970]]
* [[Vortioksetin]] (K<sub>i</sub> = 19 nM)<ref name="vortioxetine" />
|
* [[Antidepresan]] (antagonis)
* [[Ansiolitik]] (antagonis)
* [[Nootropik]] (antagonis)
|}
== Referensi ==
{{reflist}}
[[Kategori:Reseptor terhubung-protein G]]
[[Kategori:Reseptor ionotropik]]
[[Kategori:
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