Reseptor serotonin: Perbedaan antara revisi
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'''Reseptor serotonin''' atau juga dikenal sebagai '''reseptor 5-hidroksitriptamin''' atau '''reseptor 5-HT''' adalah
== Klasifikasi ==
▲'''Reseptor serotonin''' atau juga dikenal sebagai '''reseptor 5-hidroksitriptamin''' atau '''reseptor 5-HT''' adalah suatu kelompok dari [[reseptor terhubung-protein G]] dan [[reseptor kanal ion]] (''ligand-gated ion channels'', LGIC) yang ditemukan pada [[sistem sarap pusat|sistem saraf pusat]] dan [[sistem saraf tepi]].<ref name="pmid7938165">{{cite journal |vauthors=Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP | title = International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) | journal = Pharmacol. Rev. | volume = 46 | issue = 2 | pages = 157–203 | year = 1994 | pmid = 7938165 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/46/2/157}}</ref><ref name="isbn0-397-51820-X">{{cite book |vauthors=Frazer A, Hensler JG |veditors=Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD | title = Basic Neurochemistry: Molecular, Cellular, and Medical Aspects | publisher = Lippincott-Raven | location = Philadelphia | year = 1999| pages = 263–292| isbn = 0-397-51820-X | oclc = | doi = | chapter= Chapter 13: Serotonin Receptors | chapterurl = http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=bnchm.section.963 | accessdate = 2008-04-11 }}</ref> Reseptor serotonin memperantarai neurotransmisi eksitatori (pemicuan) dan inhibitori (penghambatan) yang beraksi terhadap ligan alaminya.
Dengan pengecualian dari reseptor 5-HT3
==
▲Dengan pengecualian dari reseptor 5-HT3, suatu LGIC, semua reseptor serotonin lainnya adalah [[reseptor terhubung-protein G]] yang mengaktifkan kaskade pembawa sinyal kedua intraseluler untuk menghasilkan respon eksitatori atau inhibitori (penghambatan). Pada tahun 2014 sebuah reseptor 5-HT novel dideskripsikan yang diisolasi dari kupu-kupu putih kecil, ''Pieris rapae'', dan diberi nama pr5-HT8. Kesamaan relatif dengan kelas reseptor 5-HT lainnya adalah rendah dan tidak terdapat pada mamalia.<ref name="pmid25187179">{{cite journal |vauthors=Qi YX, Xia RY, Wu YS, Stanley D, Huang J, Ye GY |title=Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor |journal=J. Neurochem. |volume= 131|issue= |pages= 767–77|year=2014 |pmid=25187179 |doi=10.1111/jnc.12940 |url=}}</ref>
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=== Subtipe ===
Tujuh kelas reseptor serotonin mencakup total 14 reseptor serotonin dikenal.<ref name="NHM-14 receptors">{{cite book |vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | title = Molecular Neuropharmacology: A Foundation for Clinical Neuroscience | year = 2009 | publisher = McGraw-Hill Medical | location = New York | isbn =
{| class="wikitable"
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| {{Tidak}}
|
* Addiksi
* Aggresi<ref name="pmid16310183">{{cite journal |vauthors=de Boer SF, Koolhaas JM | title = 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis | journal = Eur J Pharmacol. | volume = 526 | issue = 1–3 | pages = 125–39 | year = 2005 | pmid = 16310183 | doi = 10.1016/j.ejphar.2005.09.065 }}</ref>
* Ansietas<ref name="pmid9724773">{{cite journal |vauthors=Parks CL, Robinson PS, Sibille E, Shenk T, Toth M | title = Increased anxiety of mice lacking the serotonin1A receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 195 | issue = 18 | pages = 10734–9 | year = 1998 | pmid = 9724773 | pmc = 27964 | doi=10.1073/pnas.95.18.10734}}</ref>
Baris 67 ⟶ 66:
* Fungsi kardiovaskular<ref name="pmid15802554">{{cite journal |vauthors=Nalivaiko E, Ootsuka Y, Blessing WW | title = Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits | journal = Am J Physiol Regul Integr Comp Physiol | volume = 289 | issue = 2 | pages = R596–R604 | year = 2005 | pmid = 15802554 | doi = 10.1152/ajpregu.00845.2004 }}</ref>
* Emesis<ref name="pmid8013549">{{cite journal | author = Lucot JB. | title = Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin | journal = Eur J Pharmacol. | volume = 253 | issue = 1–2 | pages = 53–60 | year = 1994 | pmid = 8013549 | doi = 10.1016/0014-2999(94)90756-0 }}</ref>
* Denyut jantung<ref name="pmid2842163" /><ref name="pmid18667366" />
* Impulsivitas<ref name="pmid15688093">{{cite journal |vauthors=Winstanley CA, Theobald DE, Dalley JW, Robbins TW | title = Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders | journal = Neuropsychopharmacology. | volume = 30 | issue = 4 | pages = 669–682 | year = 2005 | pmid = 15688093 | doi = 10.1038/sj.npp.1300610 }}</ref>
* Memori<ref name="pmid18394726">{{cite journal |vauthors=Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O | title = The role of 5-HT(1A) receptors in learning and memory | journal = Behav. Brain Res. | volume = 195 | issue = 1 | pages = 54–77 | year = 2008 | pmid = 18394726 | doi = 10.1016/j.bbr.2008.02.023 }}</ref><ref name="pmid12562581">{{cite journal |vauthors=Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K | title = Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory | journal = Am J Psychiatry | volume = 160 | issue = 2 | pages = 334–40 | year = 2003 | pmid = 12562581 | doi = 10.1176/appi.ajp.160.2.334 }}</ref>
* Mood<ref name="pmid2883013">{{cite journal |vauthors=Kennett GA, Dourish CT, Curzon G | title = Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression | journal = Eur J Pharmacol. | volume = 134 | issue = 3 | pages = 265–74 | year = 1987 | pmid = 2883013 | doi = 10.1016/0014-2999(87)90357-8 }}</ref>
* Muntah<ref name="pmid8013549" />
* Nosisepsi<ref name="pmid12595749">{{cite journal |vauthors=Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC | title = Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain | journal = Pharmacology. | volume = 67 | issue = 4 | pages = 182–194 | year = 2003 | pmid = 12595749 | doi = 10.1159/000068404 }}</ref>
* Ereksi penis<ref name="pmid9085055">{{cite journal |vauthors=Millan MJ, Perrin-Monneyron S | title = Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors | journal = Eur J Pharmacol. | volume = 321 | issue = 3 | pages = 11–3 | year = 1997 | pmid = 9085055 | doi=10.1016/S0014-2999(97)00050-2}}</ref>
Baris 80 ⟶ 79:
* Sosial<ref name="pmid17383105">{{cite journal |vauthors=Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS | title = A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy") | journal = Neuroscience | volume = 146 | issue = 2 | pages = 509–14 | year = 2007 | pmid = 17383105 | doi = 10.1016/j.neuroscience.2007.02.032 }}</ref>
* Thermoregulasi<ref name="pmid2951611">{{cite journal |vauthors=Gudelsky GA, Koenig JI, Meltzer HY | title = Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors | journal = Neuropharmacology | volume = 25 | issue = 12 | pages = 1307–13 | year = 1986 | pmid = 2951611 | doi = 10.1016/0028-3908(86)90101-2 }}</ref>
* Vasokonstriksi<ref name="pmid16455061">{{cite journal |vauthors=Ootsuka Y, Blessing WW | title = Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits | journal = Brain Res. | volume =
| <!--5-Agonis HT1A-->
'''<span style="font-size:100%;">Selektif (untuk 5-HT<sub>1A</sub> lebih dari reseptor 5-HT lainnya) </span>'''
* [[Vilazodone]] (Viibryd)
* [[F-15,599]] (senyawa untuk riset, sangat poten dan selektif untuk 5-HT<sub>1A</sub>)
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'''<span style="font-size:100%;"> Nonselektif </span>'''
* [[5-Carboxamidotryptamine|5-CT]] (poten
* [[8-OH-DPAT]] (poten)
* [[Aripiprazole]] ([[antipsikotik atipikal]])
* [[Asenapine]] ([[antipsikotik atipikal]])
* [[Buspirone]]<ref name=pharmamotion>[http://pharmacologycorner.com/serotonin-5ht-receptors-agonists-antagonist/ Pharmacology Corner > Serotonin (5-HT): receptors, agonists and antagonists] By Flavio Guzmán, M.D. on 9/08/09</ref> (agonis parsial)
* [[Vortioxetine]] (agonis parsial efikasi tinggi)<ref name="vortioxetine">"BRINTELLIX™ (vortioxetine) tablets for oral use. Full Prescribing Information, Section 12.2 (Pharmacodynamics)." Takeda Pharmaceuticals America Inc. and Lundbeck, 2013. Revised September 2013. [http://general.takedapharm.com/content/file/pi.pdf?applicationcode=396066C6-E50F-4113-ABAD-54FE9525BF7E&filetypecode=BRINTELLIXPI] {{Webarchive|url=https://web.archive.org/web/20190918205248/http://general.takedapharm.com/content/file/pi.pdf?applicationcode=396066C6-E50F-4113-ABAD-54FE9525BF7E&filetypecode=BRINTELLIXPI |date=2019-09-18 }}</ref>
* [[Ziprasidone]] (agonis parsial, K<sub>i</sub> = 3.4 nM)
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| {{Tidak}}
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* Addiksi
* Aggressi<ref name="pmid16310183" />
* Ansietas<ref name="pmid15720791">{{cite journal |vauthors=Chojnacka-Wójcik E, Klodzinska A, Tatarczynska E | title = The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action | journal = J Pharm Pharmacol. | volume = 57 | issue = 2 | pages = 253–7 | year = 2005 | pmid = 15720791 | doi = 10.1211/0022357055399 }}</ref><ref name="pmid11888549">{{cite journal |vauthors=Lin D, Parsons LH | title = Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze | journal = Pharmacol Biochem Behav. | volume = 71 | issue = 4 | pages = 581–7 | year = 2002 | pmid = 11888549 | doi = 10.1016/S0091-3057(01)00712-2 }}</ref><ref name="pmid15577451">{{cite journal |vauthors=Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E | title = Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression | journal = Behav Pharmacol. | volume = 15 | issue = 8 | pages = 523–34 | year = 2004 | pmid = 15577451 | doi = 10.1097/00008877-200412000-00001 }}</ref>
* [[Autoreseptor]]
* Belajar<ref name="pmid18394658">{{cite journal |vauthors=Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO | title = Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission | journal = Neuropharmacology | volume = 54 | issue = 7 | pages = 1041–50 | year = 2008 | pmid = 18394658 | doi = 10.1016/j.neuropharm.2008.02.007 }}</ref>
* Lokomosi<ref name="pmid10454466">{{cite journal |vauthors=McCreary AC, Bankson MG, Cunningham KA | title = Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors | journal = J Pharmacol Exp Ther. | volume = 290 | issue = 3 | pages = 965–73 | year = 1999 | pmid = 10454466 }}</ref>
* Memori<ref name="pmid18394658" />
* Mood<ref name="pmid15577451" />
* Ereksi penis<ref name="pmid9085055" />
* Perilaku seksual<ref name="pmid11965359" />
* Vasokonstriksi
|<!--5-HT1B AGONIS-->
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* [[RU 24969]]
* [[TFMPP]]
* [[Triptans]]<ref name=pharmamotion /> ([[antimigraine]]<ref name=pharmamotion />)
** [[Zolmitriptan]]
** [[Eletriptan]]
Baris 190 ⟶ 189:
* Ansietas<ref name="pmid15820416">{{cite journal |vauthors=Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J | title = Anxiogenic effects of Sumatriptan in panic disorder: a double-blind, placebo-controlled study | journal = Eur Neuropsychopharmacol. | volume = 15 | issue = 3 | pages = 279–82 | year = 2005 | pmid = 15820416 | doi = 10.1016/j.euroneuro.2004.12.002 }}</ref><ref name="pmid8736648">{{cite journal |vauthors=Feuerstein TJ, Hüring H, van Velthoven V, Lücking CH, Landwehrmeyer GB | title = 5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex | journal = Neurosci Lett. | volume =209 | issue = 3 | pages = 210–4 | year = 1996 | pmid = 8736648 | doi = 10.1016/0304-3940(96)12637-9 }}</ref>
* [[Autoreseptor]]
* Lokomosi<ref name="pmid10454466" />
* Vasokonstriksi
|<!--5-HT1D AGONIS-->
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* [[Ergotamine]]
* [[Methysergide]]
* [[Triptans]]<ref name=pharmamotion /> ([[antimigrain]]<ref name=pharmamotion />)
** [[Almotriptan]]
** [[Eletriptan]]
Baris 269 ⟶ 268:
| {{Ya}}
|
* Addiksi (modulasi secara potensial)
* Ansietas<ref name="pmid9539263">{{cite journal |vauthors=Schreiber R, Melon C, De Vry J | title = The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test | journal = Psychopharmacology (Berl). | volume = 135 | issue = 4 | pages = 383–91 | year = 1998 | pmid = 9539263 | doi = 10.1007/s002130050526 }}</ref>
* Nafsu makan
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|<!--5-HT2A ANTAGONIS-->
* [[antipsikotik atipikal]]
** [[Clozapine]]<ref name=pharmamotion />
** [[Olanzapine]]
** [[Quetiapine]]
Baris 316 ⟶ 315:
* [[Hydroxyzine]]
* [[Iloperidone]]
* [[Ketanserin]]<ref name=pharmamotion /> ([[antihypertensive]]<ref name=pharmamotion />)
* [[Methysergide]]
* [[Mianserin]]
Baris 348 ⟶ 347:
* Fungsi kardiovaskular
* Motilitas GI<ref name="pmid11877320">{{cite journal |vauthors=Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS | title = 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro | journal = Br J Pharmacol. | volume = 135 | issue = 5 | pages = 1144–1151 | year = 2002 | pmid = 11877320 | doi = 10.1038/sj.bjp.0704571 | pmc = 1573235 }}</ref>
* Tidur<ref name="pmid16339018" />
* Vasokonstriksi
|<!--5-HT2B AGONIS-->
Baris 381 ⟶ 380:
| {{Ya}}
|
* Addiksi. (modulasi secara potensial)<ref name="Bubar" />
* Ansietas<ref name="pmid9225286">{{cite journal |vauthors=Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP | title = SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist | journal = Neuropharmacology. | volume = 36 | issue = 4–5 | pages = 609–20 | year = 1997 | pmid = 9225286 | doi = 10.1016/S0028-3908(97)00038-5 }}</ref><ref name="pmid15289999">{{cite journal |vauthors=Millan MJ, Brocco M, Gobert A, Dekeyne A | title = Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade | journal = Psychopharmacology (Berl). | volume = 177 | issue = 4 | pages = 448–58 | year = 2005 | pmid = 15289999 | doi = 10.1007/s00213-004-1962-z }}</ref><ref name="pmid18523738">{{cite journal |vauthors=Millan MJ, Brocco M, Gobert A, Dekeyne A | title = S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models | journal = Psychopharmacology (Berl). | volume = 199 | issue = 4 | pages = 549–68 | year = 2008 | pmid = 18523738 | doi = 10.1007/s00213-008-1177-9 }}</ref>
* Nafsu makan
Baris 387 ⟶ 386:
* [[Heteroreceptor]] for [[norepinephrine]] and [[dopamine]]
* Lokomosi
* Mood<ref name="pmid15289999" /><ref name="pmid18523738" />
* Ereksi penis<ref name="pmid9151932">{{cite journal |vauthors=Millan MJ, Peglion JL, Lavielle G, Perrin-Monneyron S | title = 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists | journal = Eur J Pharmacol. | volume = 325 | issue = 1 | pages = 9–12 | year = 1997 | pmid = 9151932 | doi = 10.1016/S0014-2999(97)89962-1 }}</ref><ref name="pmid8001637">{{cite journal |vauthors=Stancampiano R, Melis MR, Argiolas A | title = Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission | journal = Eur J Pharmacol. | volume = 261 | issue = 1–2 | pages = 149–55 | year = 1994 | pmid = 8001637 | doi = 10.1016/0014-2999(94)90313-1 }}</ref>
* Perilaku seksual<ref name="pmid12097814" />
* Tidur<ref name="pmid12431861">{{cite journal |vauthors=Frank MG, Stryker MP, Tecott LH | title = Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor | journal = Neuropsychopharmacology | volume = 27 | issue = 5 | pages = 869–73 | year = 2002 | pmid = 12431861 | doi = 10.1016/S0893-133X(02)00353-6 | pmc = 2452994 }}</ref>
* Thermoregulasi<ref name="pmid9106912" />
* Vasokonstriksi
|<!--5-HT2C AGONIS-->
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* [[Ro60-0175]]
* [[TFMPP]]
* [[Trazodone]]<ref name=pharmamotion /> ([[hypnotic]]<ref name=pharmamotion />)
* [[YM-348]]
|<!--5-HT2C ANTAGONIS-->
* [[Agomelatine]]<ref name=pharmamotion /> ([[antidepressant]]<ref name=pharmamotion />)
* [[Amitriptyline]]
* [[Asenapine]]
* [[Klomipramin]]
* [[Klozapin]]<ref name=pharmamotion /> ([[antipsychotic]]<ref name=pharmamotion />)
* [[Siproheptadine]]
* [[Dimebolin]]
Baris 417 ⟶ 416:
* [[Haloperidol]]
* [[Iloperidone]]
* [[Ketanserin]]<ref name=pharmamotion /> ([[antihypertensive]]<ref name=pharmamotion />)
* [[Lisuride]]
* [[Methysergide]]<ref name=Rang187>{{cite book |author=Rang, H. P. |title=Pharmacology |url=https://archive.org/details/isbn_9788181479174 |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages= |isbn=0-443-07145-4 |oclc= |doi=}} Page 187</ref>
* [[Mianserin]]
* [[Mirtazapin]]
Baris 457 ⟶ 456:
* Motilitas GI<ref>{{cite web|title=Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors.|url=http://www.ncbi.nlm.nih.gov/pubmed?cmd=historysearch&querykey=1|vauthors=Michel K, Zeller F, Langer R, Nekarda H, Kruger D, Dover TJ, Brady CA, Barnes NM, Schemann M |publisher=National Center for Biotechnology Information|accessdate=10 October 2014|date=May 2005}}</ref>
* Belajar<ref name="pmid8115433">{{cite journal |vauthors=Pitsikas N, Brambilla A, Borsini F | title = Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task | journal = Pharmacol Biochem Behav. | volume = 47 | issue = 1 | pages = 95–99 | year = 1994 | pmid = 8115433 | doi = 10.1016/0091-3057(94)90116-3 }}</ref>
* Memori<ref name="pmid8115433" />
* Muntah
|<!--5-HT3 AGONIS-->
Baris 466 ⟶ 465:
|<!--5-HT3 ANTAGONIS-->
* [[Alosetron]]
* Beberapa [[antimuntah]]<ref name=pharmamotion />
** [[Dolasetron]]
** [[Ondansetron]]<ref name=pharmamotion />
** [[Granisetron]]
** [[Tropisetron]]
Baris 497 ⟶ 496:
* Motilitas GI
* Belajar<ref name="Meneses A, Hong E 1997 347–51">{{cite journal |vauthors=Meneses A, Hong E |title=Effects of 5-HT4 receptor agonists and antagonists in learning |journal=Pharmacol Biochem Behav |volume=56 |issue=3 |pages=347–51 |year=1997 |pmid=9077568 |doi=10.1016/S0091-3057(96)00224-9}}</ref><ref name="pmid9225295">{{cite journal |vauthors=Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 689–96 | year = 1997 | pmid = 9225295 | doi = 10.1016/S0028-3908(97)00055-5 }}</ref>
* Memori<ref name="Meneses A, Hong E 1997 347–51" /><ref name="pmid9225295" /><ref name="pmid9732367">{{cite journal |vauthors=Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = Role of 5-HT4 receptors in the mouse passive avoidance test | journal = J Pharmacol Exp Ther. | volume = 286 | issue = 3 | pages = 1115–21 | year = 1998 | pmid = 9732367 }}</ref>
* Mood<ref name="pmid17785179">{{Cite journal | last1 = Lucas | first1 = G. | last2 = Rymar | first2 = V. V. | last3 = Du | first3 = J. | last4 = Mnie-Filali | first4 = O. | last5 = Bisgaard | first5 = C. | last6 = Manta | first6 = S. | last7 = Lambas-Senas | first7 = L. | last8 = Wiborg | first8 = O. | last9 = Haddjeri | first9 = N. | last10 = Piñeyro | first10 = G. | last11 = Sadikot | first11 = A. F. | last12 = Debonnel | first12 = G. | doi = 10.1016/j.neuron.2007.07.041 | title = Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action | journal = Neuron | volume = 55 | issue = 5 | pages = 712–725 | year = 2007 | pmid = 17785179| pmc = }}</ref><ref name="pmid17785173">{{Cite journal | last1 = Duman | first1 = R. S. | title = A Silver Bullet for the Treatment of Depression? | doi = 10.1016/j.neuron.2007.08.011 | journal = Neuron | volume = 55 | issue = 5 | pages = 679–681 | year = 2007 | pmid = 17785173| pmc = }}</ref>
* Respirasi<ref name="Manzke2003">{{cite journal|last1=Manzke|first1=T.|title=5-HT4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia|journal=Science|volume=301|issue=5630|year=2003|pages=226–229|issn=0036-8075|doi=10.1126/science.1084674|pmid=12855812}}</ref>
Baris 505 ⟶ 504:
* [[BIMU-8]]
* [[Cinitapride]]
* [[Cisaprid]]<ref name=pharmamotion /> ([[agen prokinetik|gastroprokinetik]])
* [[Dazopride]]
* [[Metoklopramid]]
Baris 515 ⟶ 514:
* [[Zacopride]]
|<!--5-HT4 ANTAGONIS-->
* [[L-Lysine]]<ref name="pmid14676321" />
* [[Piboserod]]
|
Baris 537 ⟶ 536:
* [[5-Carboxamidotryptamine|5-CT]]
* [[Ergotamine]]
* [[Valerenic acid|Valerenic Acid]] (partial agonist)<ref name="pmid15921820" />
|<!--5-HT5A ANTAGONISTs-->
* [[Asenapine]]
Baris 559 ⟶ 558:
| {{Tidak}}
|
<small>Functions in rodents,<br />[[pseudogene]] in humans</small>
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Baris 579 ⟶ 578:
* Kognisi<ref name="pmid17069795">{{cite journal |vauthors=Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N | title = SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models | journal = European Journal of Pharmacology | volume = 553 | issue = 1–3 | pages = 109–19 |date=December 2006 | pmid = 17069795 | doi = 10.1016/j.ejphar.2006.09.049 | url = | issn = }}</ref>
* Belajar<ref name="pmid15964617">{{cite journal |vauthors=Perez-García G, Meneses A | title = Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task | journal = Pharmacology, Biochemistry, and Behavior | volume = 81 | issue = 3 | pages = 673–82 |date=July 2005 | pmid = 15964617 | doi = 10.1016/j.pbb.2005.05.005 | url = | issn = }}</ref>
* Memori<ref name="pmid15964617" />
* Mood<ref name="pmid17320917" /><ref name="pmid18234190">{{cite journal |vauthors=Wesolowska A, Nikiforuk A | title = The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats | journal = European Journal of Pharmacology | volume = 582 | issue = 1–3 | pages = 88–93 |date=March 2008 | pmid = 18234190 | doi = 10.1016/j.ejphar.2007.12.013 | url = | issn = }}</ref>
|<!--5-HT6 AGONIS-->
* [[EMD-386,088]]
Baris 598 ⟶ 597:
* [[Ro04-6790]]
* [[SB-258,585]]
* [[SB-271,046]]<ref name="titleTarget Schizophrenia
* [[SB-357,134]]
* [[SB-399,885]]
Baris 621 ⟶ 620:
* [[Autoreseptor]]
* Memori<ref name="pmid18308404">{{cite journal |vauthors=Gasbarri A, Cifariello A, Pompili A, Meneses A | title = Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat | journal = Behavioural Brain Research | volume = 195 | issue = 1 | pages = 164–70 |date=December 2008 | pmid = 18308404 | doi = 10.1016/j.bbr.2007.12.020 | url = | issn = }}</ref><ref name="pmid18570192">{{cite journal |vauthors=Liy-Salmeron G, Meneses A | title = Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model | journal = Hippocampus | volume = 18 | issue = 9 | pages = 965–74 | year = 2008 | pmid = 18570192 | doi = 10.1002/hipo.20459 | url = | issn = }}</ref>
* Mood<ref name="pmid16018977" /><ref name="pmid16828124" />
* Respirasi<ref name="pmid16166206" /><ref name="pmid17314195">{{cite journal |vauthors=Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C | title = Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents | journal = J Pharmacol Exp Ther. | volume = 321 | issue = 2 | pages = 690–8 | year = 2007 | pmid = 17314195 | doi = 10.1124/jpet.107.119404 }}</ref>
* Sleep<ref name="pmid16018977" /><ref name="pmid17314195" /><ref name="pmid12812993">{{cite journal |vauthors=Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT | title = SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats | journal = Br J Pharmacol. | volume = 139 | issue = 4 | pages = 705–14 | year = 2003 | pmid = 12812993 | doi = 10.1038/sj.bjp.0705290 | pmc = 1573887 }}</ref>
* Thermoregulasi
* Vasokonstriksi
Baris 655 ⟶ 654:
|}
== Referensi ==
{{reflist}}
[[Kategori:Reseptor terhubung-protein G]]
[[Kategori:Reseptor ionotropik]]
[[Kategori:
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