Komponen komplemen 3: Perbedaan antara revisi
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'''Komponen komplemen 3''' ({{lang-en|complement component 3, C3}}) adalah salah satu [[glikoprotein]] dengan panjang 1663 [[asam amino]] yang berperan di dalam [[sistem komplemen]]<ref name="pmid11414361">{{cite journal | author = Sahu A, Lambris JD | title = Structure and biology of complement protein C3, a connecting link between innate and acquired immunity | journal = Immunol. Rev. | volume = 180 | issue = | pages = 35–48 | year = 2001 | month = April | pmid = 11414361 | doi = 10.1034/j.1600-065X.2001.1800103.x | url = }}</ref> yang terkodikasi pada [[kromosom]] 19 pada [[gen]] C3.<ref name="pmid2579379">{{cite journal | author = de Bruijn MH, Fey GH | title = Human complement component C3: cDNA coding sequence and derived primary structure | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 82 | issue = 3 | pages = 708–12 | year = 1985 | month = February | pmid = 2579379 | pmc = 397115 | url = http://www.pnas.org/content/82/3/708.abstract | doi = 10.1073/pnas.82.3.708 }}</ref><ref name = "entrez_718">{{cite web | title = Entrez Gene: C3 complement component 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=718| accessdate = }}</ref>
Aktivasi C3 diperlukan untuk memicu [[lintasan komplemen klasik]] dan [[lintasan komplemen alternatif]]. Kekurangan kadar C3 akan menurunkan [[sistem kekebalan]] terhadap [[infeksi]] [[bakteri
C3 berinteraksi dengan [[faktor komplemen H|faktor H]],<ref name=pmid9291131>{{cite journal | quotes = yes |last=Soames |first=C J |authorlink= |coauthors=Sim R B |year=[[1997]]|month=Sep. |title=Interactions between human complement components factor H, factor I and C3b |journal=Biochem. J. |volume=326 ( Pt 2) |issue= |pages=553–61 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 9291131 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11367533>{{cite journal | quotes = yes |last=Jokiranta |first=T S |authorlink= |coauthors=Westin J, Nilsson U R, Nilsson B, Hellwage J, Löfås S, Gordon D L, Ekdahl K N, Meri S |year=[[2001]]|month=Mar. |title=Complement C3b interactions studied with surface plasmon resonance technique |journal=Int. Immunopharmacol. |volume=1 |issue=3 |pages=495–506 |publisher= |location = Netherlands| issn = 1567-5769| pmid = 11367533 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> dan [[faktor komplemen B|faktor B]] yang telah teraktivasi oleh [[faktor komplemen D|faktor D]] berupa Bb, menjadi C3Bb, yang disebut C3 konvertase AP.
Baris 7:
Salah satu bentuk [[C3 konvertase]] yang disebut C4b2a, yang berbentuk [[heterodimer]] dari aktivasi [[komponen komplemen 4|C4]] dan [[komponen komplemen 2|C2]], merupakan [[enzim]] yang mengiris C3 menjadi [[komponen komplemen 3a|C3a]] dan [[komponen komplemen 3b|C3b]].
C3a merupakan [[anafilatoksin]] yang menginduksi proses [[peradangan]], kontraksi [[otot]], meningkatkan permeabilitas vaskular dan stimulan [[mastosit]] dan [[basofil]] untuk mensekresi [[histamin]],<ref>{{en}} {{cite web
| url = http://www.uniprot.org/uniprot/P01024
| title = Reviewed, UniProtKB/Swiss-Prot P01024 (CO3_HUMAN)
| accessdate = 2010-04-04
| work = UniProt
}}</ref> sedangkan C3b berfungsi sebagai [[opsonin]] dan aktivator lintasan kekebalan alternatif, juga sebagai pengikat C5.<ref>{{en}} {{cite web
| url = http://www.cehs.siu.edu/fix/medmicro/cment.htm
| title = COMPONENTS AND FUNCTIONS OF THE COMPLEMENT SYSTEM
| accessdate = 2010-04-04
| work = Southern Illinois University Carbondale
| archive-date = 2010-04-11
| archive-url = https://web.archive.org/web/20100411082148/http://www.cehs.siu.edu/fix/medmicro/cment.htm
| dead-url = yes
}}</ref>
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Di dalam lintasan komplemen alternatif, C3 teriris oleh bentuk C3 konvertase yang lain, yaitu C3bBb.
Rasio C3 dalam [[plasma darah]] sekitar
| url = http://adam.about.com/encyclopedia/Complement-component-3-C3.htm
| title = Complement component 3 (C3)
| accessdate = 2010-04-04
| work = Adam about.com
| archive-date = 2009-04-29
}}</ref> rasio yang berlebihan dapat merupakan indikasi adanya:<ref>{{en}}{{cite web▼
| archive-url = https://web.archive.org/web/20090429015412/http://adam.about.com/encyclopedia/Complement-component-3-C3.htm
| dead-url = yes
▲}}</ref> rasio yang berlebihan dapat merupakan indikasi adanya:<ref>{{en}} {{cite web
| url = http://www.nlm.nih.gov/medlineplus/ency/article/003539.htm
| title = Complement component 3 (C3)
Baris 36 ⟶ 42:
* [[Kanker]], Ulcerative colitis
sedangkan kekurangan C3 dapat berakibat klinis:
* Infeksi bakteri (khususnya Neisseria), Cirrhosis, Glomerulonephritis, Hepatitis, Hereditary angioedema, Kidney transplant rejection, Lupus nephritis, Malnutrition, Systemic lupus, erythematosus
== Rujukan ==
{{reflist}}
== Pranala luar ==
* {{en}} [http://www.jimmunol.org/cgi/content/abstract/149/11/3554 Primary structure of cobra complement component C3] Department of Biochemistry and Molecular Biology, Georgetown University
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[[Kategori:Sistem kekebalan]]▼
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