Faktor PTA: Perbedaan antara revisi
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'''Faktor PTA''' ({{lang-en|plasma thromboplastin antecedent, PTA, antihemophilic factor C, PTA factor, plasma thromboplastin factor C, PTF-C, Factor XI, FXI}}) adalah [[zimogen]] dari jenis [[serina protease]] yang merupakan prekursor dari [[faktor XIa]], yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma [[tromboplastin]] intrinsik<ref>{{en}} {{cite web
| url = http://medical-dictionary.thefreedictionary.com/factor+VI
| title = Factors
| accessdate = 2010-04-29
| work = Farlex free dictionary
| archive-date = 2021-10-18
}}</ref> saat darah terpapar oleh permukaan asing.<ref>{{en}}{{cite web▼
| archive-url = https://web.archive.org/web/20211018212340/https://medical-dictionary.thefreedictionary.com/factor+VI
| dead-url = no
▲}}</ref> saat darah terpapar oleh permukaan asing.<ref>{{en}} {{cite web
| url = http://www.answers.com/topic/factor-xi
| title = Factor XI
| accessdate = 2010-04-29
| work = Answer.com
| archive-date = 2016-03-04
| archive-url = https://web.archive.org/web/20160304205953/http://www.answers.com/topic/factor-xi
| dead-url = no
}}</ref> Pada [[manusia]], FXI terkodikasi dalam [[gen]] F11.<ref name="pmid3636155">{{cite journal | author = Fujikawa K, Chung DW, Hendrickson LE, Davie EW | title = Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein | journal = Biochemistry | volume = 25 | issue = 9 | pages = 2417–24 | year = 1986 | month = May | pmid = 3636155 | doi = 10.1021/bi00357a018| url = | issn = }}</ref><ref name="pmid2827746">{{cite journal | author = Asakai R, Davie EW, Chung DW | title = Organization of the gene for human factor XI | journal = Biochemistry | volume = 26 | issue = 23 | pages = 7221–8 | year = 1987 | month = November | pmid = 2827746 | doi = 10.1021/bi00397a004| url = | issn = }}</ref><ref name="pmid2612218">{{cite journal | author = Kato A, Asakai R, Davie EW, Aoki N | title = Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4 | journal = Cytogenet. Cell Genet. | volume = 52 | issue = 1-2 | pages = 77–8 | year = 1989 | pmid = 2612218 | doi = 10.1159/000132844| url = | issn = }}</ref><ref name="pmid1673289">{{cite journal | author = Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ | title = A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates | journal = Am. J. Hum. Genet. | volume = 48 | issue = 5 | pages = 911–25 | year = 1991 | month = May | pmid = 1673289 | pmc = 1683054 | doi = | url = | issn = }}</ref>
FXI disintesis oleh [[hati]] dan disekresi dalam bentuk [[dimer|homo-dimer]] yang tidak aktif<ref name="pmid18441012">{{cite journal | author = Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN | title = Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa | journal = J. Biol. Chem. | volume = 283 | issue = 27 | pages = 18655–64 | year = 2008 | month = July | pmid = 18441012 | doi = 10.1074/jbc.M802275200 | url = | issn = }}</ref> dengan [[waktu paruh]] sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.<ref>{{en}} {{cite web
| url = http://emedicine.medscape.com/article/209984-overview
| title = Factor XI Deficiency
| accessdate = 2010-04-29
| work = Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel.
| archive-date = 2019-08-24
| archive-url = https://web.archive.org/web/20190824133848/https://emedicine.medscape.com/article/209984-overview
| dead-url = no
}}</ref>
== Rujukan ==
{{reflist}}
== Pranala luar ==
* {{en}} [http://peir.path.uab.edu/coag UAB Coagulation Service] {{Webarchive|url=https://web.archive.org/web/20100703044746/http://peir.path.uab.edu/coag/ |date=2010-07-03 }}. Department of Pathology, UAB Hospital.
== Bacaan lanjut ==
* {{en}}[http://content.nejm.org/cgi/content/full/342/10/696 High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis] {{Webarchive|url=https://web.archive.org/web/20100305103009/http://content.nejm.org/cgi/content/full/342/10/696 |date=2010-03-05 }}. New England Journal of Medicine; Joost C.M. Meijers, Winnie L.H. Tekelenburg, et al.
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[[Kategori:Faktor koagulasi]]
[[Kategori:Enzim]]
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