Fosfatidil inositol-3 kinase: Perbedaan antara revisi
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PI3K diaktivasi oleh [[hormon]] [[tri-iodotironina]] dengan bantuan [[integrin alfavbeta3]] dalam sintesis transporter ion yang disebut ATP sintase.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/20051527
| title = Molecular aspects of thyroid hormone actions
| accessdate = 2010-07-22
| work = Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Cheng SY, Leonard JL, Davis PJ.
| archive-date = 2019-06-06
| archive-url = https://web.archive.org/web/20190606150232/https://www.ncbi.nlm.nih.gov/pubmed/20051527
| dead-url = no
}}</ref> Banyak orang berpendapat bahwa respon biologis yang distimulasi oleh [[insulin]], dikendalikan oleh enzim ini, termasuk proses penyerapan [[gula darah]], sintesis [[glikogen]] dan [[protein]]. Enzim ini memiliki [[koenzim]] [[kinase PB|(PKB/c-Akt/Rac)]] yang menghambat enzim [[glikogen sintase kinase 3]] dan mengaktivasi [[serina kinase]] yang meningkatkan laju sintesis [[glikogen]] dan protein,<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/9478990
| title = Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
| accessdate = 2010-06-21
| work = Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo; Ueki K, Yamamoto-Honda R, Kaburagi Y, Yamauchi T, Tobe K, Burgering BM, Coffer PJ, Komuro I, Akanuma Y, Yazaki Y, Kadowaki T.
| archive-date = 2016-07-17
| archive-url = https://web.archive.org/web/20160717192640/http://www.ncbi.nlm.nih.gov/pubmed/9478990
| dead-url = no
}}</ref> menginduksi produksi [[fosfatidil inositol 3,4,5-trifosfat]] yang merupakan [[molekul]] sinyal yang menyebabkan translokasi Akt menuju [[membran plasma]] guna proses [[fosforilasi]] dan aktivasi oleh enzim PDK-1 dan PDK-2.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/15505410
| title = PI3K-Akt pathway: its functions and alterations in human cancer.
| accessdate = 2011-07-12
| work = Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University; Osaki M, Oshimura M, Ito H.
| archive-date = 2019-03-26
| archive-url = https://web.archive.org/web/20190326232803/https://www.ncbi.nlm.nih.gov/pubmed/15505410
| dead-url = no
}}</ref>
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