Fosfatidil inositol-3 kinase: Perbedaan antara revisi
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'''Kinase fosfatidil inositol-3''' ({{lang-en|phosphatidyl inositol-3 kinase, Phosphoinositide 3-kinases, PI3K}}) merupakan [[enzim]] [[kinase]] [[lipid]] yang berperan dalam perkembangan sel, proliferasi, diferensiasi, ''motility'', transduksi sinyal intraselular, termasuk [[transporter glukosa#GLUT12|GLUT12]].<ref>{{en}} {{cite web
| url = http://jcem.endojournals.org/cgi/content/abstract/jc.2009-0162v1
| title = Insulin-Stimulated Translocation of GLUT12 Parallels That of GLUT4 in Normal Muscle
| accessdate = 2010-05-05
| work = Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine; Charles A. Stuart, et al.
}}{{Pranala mati|date=Maret 2021 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>
}}</ref>.▼
Enzim ini pertama kali ditemukan oleh [[Lewis C. Cantley]].
| url = http://www.ncbi.nlm.nih.gov/pubmed/20051527
| title = Molecular aspects of thyroid hormone actions
| accessdate = 2010-07-22
| work = Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Cheng SY, Leonard JL, Davis PJ.
| archive-date = 2019-06-06
}}</ref> Banyak orang berpendapat bahwa respon biologis yang distimulasi oleh [[insulin]], dikendalikan oleh enzim ini, termasuk proses penyerapan [[gula darah]], sintesis [[glikogen]] dan [[protein]]. Enzim ini memiliki koenzim [[protein kinase B]] (PKB/c-Akt/Rac) yang menghambat enzim [[glikogen sintase kinase 3]] dan mengaktivasi [[serina kinase]] yang meningkatkan laju sintesis glikogen dan protein.<ref>{{en}}{{cite web▼
| archive-url = https://web.archive.org/web/20190606150232/https://www.ncbi.nlm.nih.gov/pubmed/20051527
| dead-url = no
▲}}</ref> Banyak orang berpendapat bahwa respon biologis yang distimulasi oleh [[insulin]], dikendalikan oleh enzim ini, termasuk proses penyerapan [[gula darah]], sintesis [[glikogen]] dan [[protein]]. Enzim ini memiliki [[koenzim]] [[
| url = http://www.ncbi.nlm.nih.gov/pubmed/9478990
| title = Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
| accessdate = 2010-06-21
| work = Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo; Ueki K, Yamamoto-Honda R, Kaburagi Y, Yamauchi T, Tobe K, Burgering BM, Coffer PJ, Komuro I, Akanuma Y, Yazaki Y, Kadowaki T.
| archive-date = 2016-07-17
| archive-url = https://web.archive.org/web/20160717192640/http://www.ncbi.nlm.nih.gov/pubmed/9478990
| dead-url = no
}}</ref> menginduksi produksi [[fosfatidil inositol 3,4,5-trifosfat]] yang merupakan [[molekul]] sinyal yang menyebabkan translokasi Akt menuju [[membran plasma]] guna proses [[fosforilasi]] dan aktivasi oleh enzim PDK-1 dan PDK-2.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/15505410
| title = PI3K-Akt pathway: its functions and alterations in human cancer.
| accessdate = 2011-07-12
| work = Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University; Osaki M, Oshimura M, Ito H.
| archive-date = 2019-03-26
| archive-url = https://web.archive.org/web/20190326232803/https://www.ncbi.nlm.nih.gov/pubmed/15505410
| dead-url = no
== Rujukan ==
Baris 27 ⟶ 41:
[[Kategori:Enzim|Kinase Fosfatidil inositol]]
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