Glutamat karboksipeptidase II: Perbedaan antara revisi
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[[Berkas: 2or4.jpg|jmpl|glutamate carboxypeptidase II, dimer, Human.]]
'''Karboksipeptidase glutamat II''' ({{lang-en|glutamate carboxypeptidase II, N-acetylated-γ-linked-acidic dipeptidase (NAALADase); folate hydrolase; prostate-specific membrane antigen; pteroylpoly-γ-glutamate carboxypeptidase; microsomal γ-glutamyl carboxypeptidase; pteroylpolyglutamate hydrolase; folylpolyglutamate hydrolase; pteroylpoly-γ-glutamate hydrolase; pteroylpolygammaglutamyl hydrolase; pteroylpolyglutamate hydrolase; pteroylpolyglutamic acid hydrolase; PSM antigen; acetylaspartylglutamate dipeptidase; NAALA dipeptidase; rat NAAG peptidase; mGCP; membrane glutamate carboxypeptidase; N-acetylated-α-linked-amino dipeptidase; prostrate-specific membrane antigen; N-Acetylated α-linked acidic dipeptidase; NAALADase, PSMA, EC 3.4.17.21}}) merupakan [[enzim]] dengan aktivitas [[hidrolisis]] terhadap [[ikatan peptida]]-α, seperti Ac-[[asam aspartat|Asp]]-[[asam glutamat|Glu]], Asp-Glu, dan Glu-Glu; dan [[ikatan glutamil]]-γ seperti γ-Glu-Glu, dan folilpoli-γ-glutamat, yang dijumpai sebagai protein integral membran dan serum protein di dalam darah.<ref>{{en}} {{cite web
| url = http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/4/17/21.html
| title = EC 3.4.17.21
| accessdate = 2010-12-05
| work = Queen Mary University of London
| archive-date = 2016-11-11
| archive-url = https://web.archive.org/web/20161111065755/http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/4/17/21.html
| dead-url = no
}}</ref>
Aktivitas PSMA dihambat oleh ''quisqualic acid'', ''Ac-beta-Asp-Glu'', dan ''2-phosphonomethyl-pentanedioate'',<ref>{{en}} {{cite web
| url = http://merops.sanger.ac.uk/cgi-bin/smi_summary?mid=J13.402
| title = Literature Small-molecule inhibitor J13.402: PMPA
| accessdate = 2010-12-05
| work = Wellcome Trust Sanger Institute
}}</ref> dan sebelumnya dikategorikan sebagai EC 3.4.19.8.<ref>{{en}} {{cite web
| url = http://www.expasy.org/enzyme/3.4.17.21
| title = ENZYME entry: EC 3.4.17.21
| accessdate = 2010-12-05
| work = Swiss Institute of Bioinformatics
| archive-date = 2011-06-04
}}</ref> Dihambatnya aktivitas PSMA merupakan salah satu terapi perawatan terhadap penderita [[sklerosis lateral amiotrofik]].<ref>{{en}}{{cite web▼
| archive-url = https://web.archive.org/web/20110604000204/http://www.expasy.org/enzyme/3.4.17.21
| dead-url = no
▲}}</ref> Dihambatnya aktivitas PSMA merupakan salah satu terapi perawatan terhadap penderita [[sklerosis lateral amiotrofik]].<ref>{{en}} {{cite web
| url = http://merops.sanger.ac.uk/cgi-bin/pepsum?mid=m28.010
| title = Summary for peptidase M28.010: glutamate carboxypeptidase II
| accessdate = 2010-12-05
| work = Wellcome Trust Sanger Institute
| archive-date = 2016-03-04
| archive-url = https://web.archive.org/web/20160304223545/http://merops.sanger.ac.uk/cgi-bin/pepsum?mid=m28.010
| dead-url = no
}}</ref>
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