Kreatinina: Perbedaan antara revisi
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Baris 1:
{{Chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 460107980
| ImageFile = Creatinine-tautomerism-2D-skeletal.svg
| ImageFile1 = Creatinine-tautomerism-3D-balls.png
| PIN = 2-Amino-1-methyl-5''H''-imidazol-4-one{{Citation needed|date = October 2011}}
| SystematicName = 2-Amino-1-methyl-1''H''-imidazol-4-ol{{Citation needed|date = October 2011}}
| OtherNames = 2-Amino-1-methylimidazol-4-ol{{Citation needed|date = October 2011}}
| Section1 = {{Chembox Identifiers
| CASNo = 60-27-5
| CASNo_Ref = {{cascite|correct|CAS}}
| PubChem = 26009888
| PubChem_Ref = {{Pubchemcite|correct|Pubchem}}
| PubChem1 = 588
| PubChem1_Ref = {{Pubchemcite|correct|Pubchem}}
| PubChem1_Comment = minor tautomer
| ChemSpiderID = 21640982
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| UNII = AYI8EX34EU
| UNII_Ref = {{fdacite|correct|FDA}}
| EINECS = 200-466-7
| UNNumber = 1789
| KEGG = D03600
| KEGG_Ref = {{keggcite|correct|kegg}}
| MeSHName = Creatinine
| ChEBI = 16737
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 65567
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| Beilstein = 112061
| 3DMet = B00175
| SMILES = CN1C=C(O)N=C1N
| StdInChI = 1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2,8H,1H3,(H2,5,6)
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| InChI = 1/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)
| StdInChIKey = BTXYOFGSUFEOLA-UHFFFAOYSA-N
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| InChIKey = DDRJAANPRJIHGJ-UHFFFAOYAV
}}
| Section2 = {{Chembox Properties
| C=4|H=7|N=3|O=1
| ExactMass = 113.058911861 g mol<sup>-1</sup>
| Appearance = White crystals
| Density = 1.09 g cm<sup>-3</sup>
| MeltingPt = 300 °C (decomp.)<ref name=Merck>''[[Merck Index]]'', 11th Edition, '''2571'''</ref>
| Solubility = 1 part per 12<ref name=Merck/>
| LogP = -1.76
| pKa = 12.309
| pKb = 1.688
| IsoelectricPt = 11.19
}}
| Section3 = {{Chembox Thermochemistry
| DeltaHf = -240.81--239.05 kJ mol<sup>-1</sup>
| DeltaHc = -2.33539--2.33367 MJ mol<sup>-1</sup>
| Entropy = 167.4 J K<sup>-1</sup> mol<sup>-1</sup>
| HeatCapacity = 138.1 J K<sup>-1</sup> mol<sup>-1</sup> (at 23.4 °C)
}}
| Section3 = {{Chembox Hazards
| EUClass = {{Hazchem Xn}}
| RPhrases = {{R34}}, {{R36/37/38}}, {{R20/21/22}}
| SPhrases = {{S26}}, {{S36/37/39}}, {{S45}}, {{S24/25}}, {{S36}}
| NFPA-F = 1
| NFPA-H = 1
| NFPA-R = 0
| FlashPt = {{convert|290|C|F}}
}}
}}
[[Berkas:Creatinine-tautomerism-2D-skeletal.svg|jmpl|ka|300px|Kreatinina.]]
'''Kreatinin''' ({{lang-el|κρέας}}, daging) merupakan produk hasil reaksi [[hidrolisis]] pada [[fosfokreatina]] yang terjadi di otot, yang terjadi dengan ritme yang cukup konstan (tergantung pada massa [[otot]]).
Sejumlah besar kreatinin yang terdapat dalam sirkulasi darah akan disaring keluar bersama dengan [[urin]],<ref>{{Cite book|last=Parker|first=Sybil, P|date=1984|title=McGraw-Hill Dictionary of Biology|publisher=McGraw-Hill Company|url-status=live}}</ref> dan tidak diserap kembali ke dalam darah. Oleh karena itu, rasio konsentrasi kreatinin di dalam darah dan urin, dapat digunakan untuk menghitung rasio luaran kreatinin ({{lang-en|creatinine clearance, CrCl}}), yang setara dengan laju filtrasi glomerular ({{lang-en|glomerular fltration rate, GFR}}).
GFR mempunyai arti klinis yang sangat penting karena merupakan standar ukuran fungsi [[ginjal]], selain [[Sistatin C]].
Baris 11 ⟶ 79:
Kadar kreatinin pada pria max 1,6 kalau sudah melebihi 1,7 harus hati-hati. Jangan-jangan nanti memerlukan cuci darah
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== Referensi ==
{{Reflist}}
[[Kategori:Protein darah]]
[[Kategori:Metabolisme]]
[[Kategori:Senyawa karbon]]
[[Kategori:Senyawa nitrogen]]
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