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'''Parry–Romberg syndrome''' (dikenal juga sebagai '''atrofi hemifacial progresif''') adalah [[penyakit langka]] yang ditandai dengan penyusutan bertingkat dan degenerasi [[Hipodermis|jaringan di bawah kulit]], biasanya terjadi hanya pada satu sisi wajah ([[atrofi]] hemifacial) tapi terkadang meluas ke bagian tubuh lainnya.<ref>{{Cite journal|date=February 2012|title=Case 178: Parry-Romberg syndrome|url=|journal=Radiology|volume=262|issue=2|pages=721–725|doi=10.1148/radiol.11092104}}</ref> Dicurigai karena mekanisme [[Penyakit autoimun|autoimun]], dan kemungkinan merupakan varian dari penyakit scleroderma yang bersifat lokal, tetapi [[etiologi]] dan [[patogenesis]] secara pasti masih belum diketahui. Penyakit ini pertama kali dideskripsikan oleh Parry pada tahun 1825 dan Romberg pada tahun 1846.<ref>{{Cite journal|date=2015 Jan-Feb|title=Localized scleroderma: clinical spectrum and therapeutic update|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323700/|journal=An Bras Dermatol.|volume=90|issue=1|pages=62–73|doi=10.1590/abd1806-4841.20152890}}</ref> Dalam literatur telah dilaporkan sebagai sebuah konsekuensi yang mungkin dari [[simpatektomi]]. Sindrom ini memiliki [[prevalensi]] yang lebih tinggi pada wanita dan biasanya muncul antara umur 5{{Spaced ndash}}15 tahun.
Selain [[penyakit jaringan ikat]], kondisi ini kadang-kadang disertai dengan gangguan saraf, gejala mata dan mulut. Jangkauan dan tingkat keparahan dari gejala-gejala yang ditemukan sangat bervariasi.
== Referensi ==
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name=UWHCA2011>{{cite web|author=University of Wisconsin Hospitals and Clinics Authority|title=UW health surgeon reconstructs young girl's face|work=News for referring physicians|publisher=University of Wisconsin Hospitals and Clinics Authority|location=Madison, Wisconsin|date=2011-05-17|url=http://www.uwhealth.org/referring-physician-news/uw-health-surgeon-reconstructs-young-girls-face/31371|accessdate=2011-08-02}}</ref> <ref name=Wartenberg1945>{{cite journal|last=Wartenberg|first=R|title=Progressive facial hemiatrophy (abstract)|journal=Archives of Neurology and Psychiatry|volume=54|issue=2|pages=75–97|year=1945|url=http://archneurpsyc.ama-assn.org/cgi/content/summary/54/2/75|doi=10.1001/archneurpsyc.1945.02300080003001}}</ref> <ref name=WhoNamedIt>{{WhoNamedIt|synd|1285}}</ref> <ref name=Wolf1974>{{cite journal|last=Wolf|first=SM|last2=Verity|first2=MA|title=Neurological complications of progressive facial hemiatrophy|journal=Journal of Neurology, Neurosurgery and 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