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#ALIH [[Diklofenak]]
{{Short description|Nonsteroidal anti-inflammatory drug}}
{{Use dmy dates|date=January 2024}}
{{Infobox drug
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 443636249
| image = Diclofenac.svg
| width = 250
| alt =
| image2 = Diclofenac-from-xtal-3D-bs-17.png
| width2 = 250
| alt2 =
<!--Clinical data-->
| tradename = Cataflam, Voltaren, Zipsor, [[#trade names|dll]]<ref name=tn/>
| Drugs.com = {{drugs.com|monograph|diclofenac-epolamine}}
| MedlinePlus = a689002
| DailyMedID = Diclofenac
| pregnancy_AU = C
| pregnancy_AU_comment = <ref name="Drugs.com pregnancy">{{cite web | title=Diclofenac Use During Pregnancy | website=Drugs.com | date=16 January 2000 | url=https://www.drugs.com/pregnancy/diclofenac.html | access-date=15 February 2020 | archive-date=29 July 2020 | archive-url=https://web.archive.org/web/20200729232727/https://www.drugs.com/pregnancy/diclofenac.html | url-status=live }}</ref>
| routes_of_administration = [[Oral administration|By mouth]], [[Rectal administration|rectal]], [[intramuscular]], [[intravenous]], [[Topical medication|topical]]
| ATC_prefix = D11
| ATC_suffix = AX18
| ATC_supplemental = {{ATC|M01|AB05}}, {{ATC|M02|AA15}}, {{ATC|S01|BC03}}
| legal_AU = S4
| legal_AU_comment = / S3 / S2
| legal_UK = POM
| legal_UK_comment = / P / GSL
| legal_US = Rx-only
| legal_US_comment = / OTC<ref name="FDA switch">{{cite web | title=FDA Approves Three Drugs for Nonprescription Use Through Rx-to-OTC Switch Process | website=U.S. [[Food and Drug Administration]] (FDA) | date=14 February 2020 | url=http://www.fda.gov/news-events/press-announcements/fda-approves-three-drugs-nonprescription-use-through-rx-otc-switch-process | archive-url=https://web.archive.org/web/20200215012930/https://www.fda.gov/news-events/press-announcements/fda-approves-three-drugs-nonprescription-use-through-rx-otc-switch-process | archive-date=15 February 2020 | url-status=live | access-date=14 February 2020}} {{PD-notice}}</ref>
| legal_status = Rx-only
<!--Pharmacokinetic data-->
| protein_bound = More than 99%
| metabolism = Liver, oxidative, primarily by [[CYP2C9]], also by [[CYP2C8]], [[CYP3A4]], as well as conjugative by [[glucuronidation]] ([[UGT2B7]]) and [[sulfation]];<ref>{{cite web|url=http://www.medicinereviews.ooo/2018/08/diclofenac-oral-uses-dosage-side.html|title=Diclofenac Oral Uses, Dosage, Side Effects And Composition|publisher=Medicine Reviews Agency| vauthors = Sayyad M |date=23 August 2018|access-date=24 August 2018|archive-url=https://web.archive.org/web/20180824135214/https://www.medicinereviews.ooo/2018/08/diclofenac-oral-uses-dosage-side.html|archive-date=24 August 2018|url-status=dead}}</ref> no active metabolites exist
| onset = Within 4 hours (gel),<ref>{{cite web |title=How Long Does It Take for Voltaren Gel to Work? |url=https://www.youdrugstore.com/health/voltaren-gel-usage.html |website=YouDrugstore |access-date=1 June 2020 |language=en-CA |archive-date=30 July 2020 |archive-url=https://web.archive.org/web/20200730041151/https://www.youdrugstore.com/health/voltaren-gel-usage.html |url-status=live }}</ref> 30 min (non-gel)<ref name="AHFS2018" />
| elimination_half-life = 1.2–2 [[hour|h]] (35% of the drug enters enterohepatic recirculation)
| excretion = 35% [[bile]], 65% [[urine]]<ref>{{cite book |vauthors=Williams BS, Buvanendran A |chapter=Chapter 17 - Nonopioid analgesics: NSAIDs, COX-2 inhibitors, and acetaminophen |date=1 January 2011 |chapter-url=https://www.sciencedirect.com/science/article/pii/B9781437722420000262 |title=Essentials of Pain Medicine |edition=Third |pages=130–139 |veditors=Benzon HT, Raja SN, Liu SS, Fishman SM |publisher=W.B. Saunders |language=en |doi=10.1016/b978-1-4377-2242-0.00026-2 |isbn=978-1-4377-2242-0 |access-date=10 January 2023 |archive-date=10 January 2023 |archive-url=https://web.archive.org/web/20230110202200/https://www.sciencedirect.com/science/article/pii/B9781437722420000262 |url-status=live }}</ref>
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 15307-86-5
| PubChem = 3033
| IUPHAR_ligand = 2714
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00586
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2925
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 144O8QL0L1
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07816
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 47381
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 139
| PDB_ligand = DIF
<!--Chemical data-->
| IUPAC_name = [2-(2,6-Dichloroanilino)phenyl]acetic acid <!-- the locant '2' for acetic acid is not cited, see P-14.3.4.3 Nomenclature of Organic Chemistry – IUPAC Recommendations and Preferred Names 2013 (Blue Book) -->
| C = 14
| H = 11
| Cl = 2
| N = 1
| O = 2
| smiles = O=C(O)Cc1ccccc1Nc2c(Cl)cccc2Cl
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = DCOPUUMXTXDBNB-UHFFFAOYSA-N
}}
'''Natrium diklofenak''' adalah [[obat]] antiinflamasi golongan [[Obat antiinflamasi nonsteroid|NSAID]] (Nonsteroid ).<ref name=":0">{{Cite web|title=Diclofenac Uses, Dosage & Side Effects|url=https://www.drugs.com/diclofenac.html|website=Drugs.com|language=en|access-date=2024-02-04}}</ref> Natrium diklofenak memiliki mekanisme kerja dengan cara mengurangi zat-zat dalam tubuh yang menyebabkan rasa sakit dan peradangan.<ref name=":0" /> Natrium diklofenak digunakan untuk mengobati nyeri ringan hingga sedang, atau tanda dan gejala [[osteoartritis]] atau reumatoid artritis .<ref name=":0" />
== Referensi ==
<references />
{{Farmasi-stub}}
[[Kategori:Obat Esensial Nasional Indonesia]]
[[Kategori:Farmasi]]
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