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{{Infobox drug|routes_of_administration=[[Subcutaneous injection|Subcutaneous]]|duration_of_action=|legal_status=<!-- For countries not listed above -->|bioavailability=80%|protein_bound=[[Albumin]]|metabolism=[[Proteolysis|Proteolytic cleavage]], [[Beta oxidation|β-oxidation]] of fatty diacid section and [[Hydrolysis#Esters and amides|amide hydrolysis]]|metabolites=|elimination_half-life=Five days|melting_point=|melting_high=|boiling_point=}}
'''Tirzepatide''', adalah obat yang digunakan untuk mengatasi [[Diabetes melitus tipe 2|diabetes tipe 2]] dan [[Kegemukan|obesitas]] . <ref name="PI2022">{{Cite web| title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}</ref> <ref name="Jas2023">{{Cite journal|last=Jastreboff|first=Ania M.|last2=Aronne|first2=Louis J.|last3=Ahmad|first3=Nadia N.|last4=Wharton|first4=Sean|last5=Connery|first5=Lisa|last6=Alves|first6=Breno|last7=Kiyosue|first7=Arihiro|last8=Zhang|first8=Shuyu|last9=Liu|first9=Bing|date=2022-07-21|title=Tirzepatide Once Weekly for the Treatment of Obesity|url=http://www.nejm.org/doi/10.1056/NEJMoa2206038|journal=New England Journal of Medicine|language=en|volume=387|issue=3|pages=205–216|doi=10.1056/NEJMoa2206038|issn=0028-4793|archive-url=https://web.archive.org/web/20230506234503/https://www.nejm.org/doi/10.1056/NEJMoa2206038|archive-date=2023-05-06|access-date=2023-05-07|url-status=live}}</ref> Obat ini baiknya digunakan bersama dengan diet dan juga olahraga. <ref name="PI2022">{{citeweb | title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}</ref> Rute pemberian obat digunakan melalui [[Penyuntikan subkutan|penyuntinkan subkutan]] . <ref name="PI2022">{{citeweb | title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}</ref>
Efek samping yang umum terjadi pada penggunaan obat ini seperti rasa mual, diare, sembelit, dan sakit perut. <ref name="PI2022">{{Citeweb| title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}<cite class="citation web cs1" data-ve-ignore="true">[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 "Mounjaro- tirzepatide injection, solution"]. ''DailyMed''. 13 May 2022. [https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 Archived] from the original on 3 July 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">27 May</span> 2022</span>.</cite></ref> Efek samping lain yang perlu diperhatikan selama penggunaan obat ini yakni [[pankreatitis]], [[hipoglikemia]], muncul reaksi alergi, dan penyakit kandung empedu . <ref name="PI2022">{{citeweb | title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}</ref> Tidak bisa digunakan untuk ibu hamil karena, bisa membahayakan bayi. <ref name="PI2022">{{citeweb | title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}</ref> Tirzepatide merupakan aktivator reseptor [[GLP-1|peptida-1 (GLP-1) mirip glukagon]] dan [[GIP|polipeptida insulinotropik (GIP) yang bergantung pada glukosa]] dan meningkatkan pelepasan [[insulin]] dengan makanan. <ref name="PI2022">{{citeweb | title=Mounjaro- tirzepatide injection, solution | website=DailyMed | date=13 May 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | access-date=27 May 2022 | archive-date=3 July 2022 | archive-url=https://web.archive.org/web/20220703054225/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0 | url-status=live }}</ref> <ref name="EPAR2022">{{Cite web|title=Mounjaro|url=https://www.ema.europa.eu/en/medicines/human/EPAR/mounjaro|archive-url=https://web.archive.org/web/20221212220255/https://www.ema.europa.eu/en/medicines/human/EPAR/mounjaro|archive-date=12 December 2022|access-date=12 December 2022|url-status=live}}</ref>
== Referensi ==
[[Kategori:ObatNeuropeptida]]
[[Kategori:DiabetesHormon sistem pencernaan]]
[[Kategori:FarmasiObat yang dikembangkan oleh Eli Lilly and Company]]
