Rabeprazol: Perbedaan antara revisi

'''Rabeprazol''' (merek dagang '''Pariet''') merupakan obat golongan [[Penghambat pompa proton|PPI]] (''proton pump inhibitor'') yang menurunkan produksi [[asam lambung]]. Rabeprazol digunakan untuk mengatasi produksi asam lambung yang berlebih seperti pada [[sindrom Zollinger-Ellison]] dan untuk ulkus duodenum atau erosi [[esofagitis]] (kerusakan [[esofagus]] karena asam lambung).<ref name=":0">{{Cite web|url=https://medlineplus.gov/druginfo/meds/a699060.html|title=Rabeprazole: MedlinePlus Drug Information|last=|first=|date=|website=medlineplus.gov|language=|access-date=13 November 2019}}</ref><ref name=":1">{{Cite web|url=https://www.drugs.com/mtm/rabeprazole.html|title=Rabeprazole Uses, Side Effects & Warnings|last=|first=|date=|website=Drugs.com|language=|access-date=22 Maret 2020}}</ref><ref name=":2">{{Cite web|url=https://www.webmd.com/drugs/2/drug-17504/rabeprazole-oral/details|title=Drugs & Medications|last=|first=|date=|website=www.webmd.com|language=|access-date=22 Maret 2020}}</ref><ref name=":7">{{Cite web|url=https://www.mayoclinic.org/drugs-supplements/rabeprazole-oral-route/description/drg-20066981|title=Rabeprazole (Oral Route) Description and Brand Names - Mayo Clinic|last=|first=|date=|website=www.mayoclinic.org|access-date=22 Maret 2020}}</ref><ref>{{Cite web|url=http://pionas.pom.go.id/monografi/natrium-rabeprazol|title=NATRIUM RABEPRAZOL {{!}} PIO Nas|last=|first=|date=|website=pionas.pom.go.id|access-date=23 Maret 2020|archive-date=2020-03-23|archive-url=https://web.archive.org/web/20200323020051/http://pionas.pom.go.id/monografi/natrium-rabeprazol|dead-url=yes}}</ref>

Penggunaan rabeprazol bersamaan dengan obat anti[[retrovirus]] memberikan reaksi yang berbeda-beda. Pemberiannya bersama dengan [[saquinavir]]<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/rabeprazole-with-saquinavir-1983-0-2044-0.html?professional=1|title=Rabeprazole and saquinavir Drug Interactions|last=|first=|date=|website=Drugs.com|language=en|access-date=26 Maret 2020}}</ref> akan meningkatkan [[toksisitas]]<nowiki/>nya. Namun pemberiannya dengan antiretroviral yang lain ([[rilpivirin]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/rabeprazole-with-rilpivirine-1983-0-3327-0.html?professional=1|title=Rabeprazole and rilpivirine Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> [[atazanavir]],<ref name="drugs.com">{{Cite web|url=https://www.drugs.com/drug-interactions/atazanavir-with-rabeprazole-272-0-1983-0.html?professional=1|title=Atazanavir and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> dan [[nelfinavir]]<ref name="drugs.com"/>) akan menurunkan efek antivirus ketiga obat tersebut dan menyebabkan resistensi. Rabeprazol yang dikonsumsi dengan [[warfarin]] akan meningkatkan [[waktu protrombin]] yang akan menyebabkan gangguan pembekuan darah. [[Metotreksat]]<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/methotrexate-with-rabeprazole-1590-0-1983-0.html?professional=1|title=Methotrexate and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> yang dikombinasikan dengan rabeprazol akan menyebabkan perpanjangan kadar metotreksat dan atau metabolitnya, hidroksimetotreksat, di dalam darah. Obat-obat yang penyerapannya tergantung kepada pH lambung seperti [[erlotinib]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/erlotinib-with-rabeprazole-1007-0-1983-0.html?professional=1|title=Erlotinib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> [[dasatinib]],<ref name="ReferenceA">{{Cite web|url=https://www.drugs.com/drug-interactions/pazopanib-with-rabeprazole-3180-0-1983-0.html?professional=1|title=Pazopanib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref>, [[neratinib]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/neratinib-with-rabeprazole-3827-0-1983-0.html?professional=1|title=Neratinib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> [[pazopanib]],<ref name="ReferenceA"/> [[peksidartinib]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/pexidartinib-with-rabeprazole-4032-0-1983-0.html?professional=1|title=Pexidartinib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> [[akalabrutinib]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/acalabrutinib-with-rabeprazole-3871-0-1983-0.html?professional=1|title=Acalabrutinib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> [[dakomitinib]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/dacomitinib-with-rabeprazole-3962-0-1983-0.html?professional=1|title=Dacomitinib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=25 Maret 2020}}</ref> [[nilotinib]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/nilotinib-with-rabeprazole-2785-0-1983-0.html?professional=1|title=Nilotinib and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=26 Maret 2020}}</ref> [[mikofenolat mofetil]],<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/mycophenolate-mofetil-with-rabeprazole-1671-0-1983-0.html?professional=1|title=Mycophenolate mofetil and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=26 Maret 2020}}</ref> dan [[itrakonazol]]<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/itraconazole-with-rabeprazole-1406-0-1983-0.html?professional=1|title=Itraconazole and rabeprazole Drug Interactions|last=|first=|date=|website=Drugs.com|language=|access-date=26 Maret 2020}}</ref> akan menurun absorbsinya. Rabeprazol juga dapat menyebabkan hasil positif palsu untuk diagnosis [[tumor neuroendokrin]] dengan cara meningkatkan kadar serum CgA (kromogranin A).<ref name=":1" /><ref name=":2" /><ref name=":5" /><ref name=":12" />

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