Protein: Perbedaan antara revisi

[[Linus Carl Pauling|Linus Pauling]] dianggap sukses dalam memperkirakan [[struktur sekunder]] protein biasa berdasarkan [[ikatan hidrogen]], sebuah ide yang pertama kali dikemukakan oleh [[William Astbury]] pada tahun 1933.<ref name="Pauling1951">{{cite journal|date=May 1951|title=Atomic coordinates and structure factors for two helical configurations of polypeptide chains|url=http://www.pnas.org/site/misc/Protein8.pdf|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=37|issue=5|pages=235–40|bibcode=1951PNAS...37..235P|doi=10.1073/pnas.37.5.235|pmc=1063348|pmid=14834145|archive-url=https://web.archive.org/web/20121128101620/http://www.pnas.org/site/misc/Protein8.pdf|archive-date=2012-11-28|access-date=2009-04-14|vauthors=Pauling L, Corey RB|url-status=live}}</ref> Belakangan, karya [[Walter Kauzmann]] tentang [[denaturasi]],<ref name="Kauzmann1956">{{cite journal|date=May 1956|title=Structural factors in protein denaturation|journal=Journal of Cellular Physiology|volume=47|issue=Suppl 1|pages=113–31|doi=10.1002/jcp.1030470410|pmid=13332017|vauthors=Kauzmann W}}</ref><ref name="Kauzmann1959">{{Cite book|vauthors=Kauzmann W|year=1959|title=Advances in Protein Chemistry Volume 14|isbn=978-0-12-034214-3|series=Advances in Protein Chemistry|volume=14|pages=1–63|chapter=Some factors in the interpretation of protein denaturation|doi=10.1016/S0065-3233(08)60608-7|pmid=14404936}}</ref> yang sebagian didasarkan pada penelitian sebelumnya oleh [[Kaj Ulrik Linderstrøm-Lang|Kaj Linderstrøm-Lang]],<ref name="Kalman1955">{{cite journal|date=February 1955|title=Degradation of ribonuclease by subtilisin|journal=Biochimica et Biophysica Acta|volume=16|issue=2|pages=297–99|doi=10.1016/0006-3002(55)90224-9|pmid=14363272|vauthors=Kalman SM, Linderstrøm-Lang K, Ottesen M, Richards FM}}</ref> memberi pemahaman tentang [[pelipatan protein]] dan struktur yang dimediasi oleh [[Inti hidrofobik|interaksi hidrofobik]].

 

 

[[Struktur protein]] pertama yang diketahhui adalah [[hemoglobin]] dan [[mioglobin]], masing-masing oleh [[Max F. Perutz|Max Perutz]] dan [[John Kendrew|Sir John Cowdery Kendrew]], pada tahun 1958.<ref name="Muirhead1963">{{cite journal|date=August 1963|title=Structure of hemoglobin. A three-dimensional fourier synthesis of reduced human hemoglobin at 5.5 Å resolution|journal=Nature|volume=199|issue=4894|pages=633–38|bibcode=1963Natur.199..633M|doi=10.1038/199633a0|pmid=14074546|vauthors=Muirhead H, Perutz MF|s2cid=4257461}}</ref><ref name="Kendrew1958">{{cite journal|date=March 1958|title=A three-dimensional model of the myoglobin molecule obtained by x-ray analysis|journal=Nature|volume=181|issue=4610|pages=662–66|bibcode=1958Natur.181..662K|doi=10.1038/181662a0|pmid=13517261|vauthors=Kendrew JC, Bodo G, Dintzis HM, Parrish RG, Wyckoff H, Phillips DC|s2cid=4162786}}</ref> {{As of|2017}}, [[Protein Data Bank|Bank Data Protein]] memiliki lebih dari 126.060 struktur protein dengan resolusi atomik.<ref name="urlRCSB Protein Data Bank">{{cite web|title=RCSB Protein Data Bank|url=http://www.rcsb.org/pdb/home/home.do|archive-url=https://web.archive.org/web/20150418160606/http://www.rcsb.org/pdb/home/home.do|archive-date=2015-04-18|access-date=2017-01-19|url-status=dead}}</ref> Baru-baru ini, mikroskop krio-elektron terhadap [[Perakitan makromolekul|kumpulan makromolekul]] besar<ref name="Zhou2008">{{cite journal|date=April 2008|title=Towards atomic resolution structural determination by single-particle cryo-electron microscopy|journal=Current Opinion in Structural Biology|volume=18|issue=2|pages=218–28|doi=10.1016/j.sbi.2008.03.004|pmc=2714865|pmid=18403197|vauthors=Zhou ZH}}</ref> dan [[prediksi struktur protein]] komputasional terhadap [[Domain struktural|domain]] protein kecil<ref name="Keskin2008">{{cite journal|date=April 2008|title=Characterization and prediction of protein interfaces to infer protein-protein interaction networks|journal=Current Pharmaceutical Biotechnology|volume=9|issue=2|pages=67–76|doi=10.2174/138920108783955191|pmid=18393863|vauthors=Keskin O, Tuncbag N, Gursoy A}}</ref> adalah dua metode yang mendekati resolusi atomik.