|
<!-- Clinical data -->|pregnancy_AU=B3|pregnancy_US=C|pregnancy_category=|routes_of_administration=[[Oral administration|By mouth]]|duration_of_action=|Drugs.com={{drugs.com|monograph|quetiapine-fumarate}}|MedlinePlus=a698019
<!-- Legal data -->|legal_AU=S4|legal_CA=Rx-only|legal_UK=POM|legal_US=Rx-only|legal_status=|DailyMedID=Quetiapine|licence_US=Quetiapine|licence_EU=<!-- Pharmacokinetic data -->|bioavailability=100%<ref name=Medscape>{{cite web|title=quetiapine (Rx) - Seroquel, Seroquel XR|url=http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|website=Medscape Reference|publisher=WebMD|access-date=11 October 2013|url-status = live|archive-url=https://web.archive.org/web/20131020163700/http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|archive-date=20 October 2013|df=}}</ref>|protein_bound=83%<ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref>|metabolism=[[Liver]] via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)<ref name = GG>{{cite book|vauthors=Brunton L, Chabner B, Knollman B|title=Goodman and Gilman's The Pharmacological Basis of Therapeutics|edition=12th|publisher=McGraw Hill Professional|year=2010|isbn=978-0071624428|url=https://books.google.com/books?id=bVUfAQAAQBAJ|access-date=2018-07-23|archive-date=2020-08-06|archive-url=https://web.archive.org/web/20200806023105/https://books.google.com/books?id=bVUfAQAAQBAJ|url-status=live}}</ref>|elimination_half-life=7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)<ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref><ref name = DD>Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.</ref>|excretion=[[Kidney]] (73%), faeces (20%)<ref name=Medscape>{{cite web|title=quetiapine (Rx) - Seroquel, Seroquel XR|url=http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|website=Medscape Reference|publisher=WebMD|access-date=11 October 2013|url-status = live|archive-url=https://web.archive.org/web/20131020163700/http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10|archive-date=20 October 2013|df=}}</ref><ref name=EMC>{{cite web|title=Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics|date=January 2013|access-date=20 October 2013|website=electronic Medicines Compendium|publisher=Sandoz|url=http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|url-status = dead|archive-url=https://web.archive.org/web/20131020062812/http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/|archive-date=20 October 2013|df=dmy-all}}</ref><ref name = DD>Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.</ref><ref name=DM>{{cite web|title=QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]|website=DailyMed|publisher=Ascend Laboratories, LLC|date=October 2013|access-date=26 November 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b|url-status = live|archive-url=https://web.archive.org/web/20131202224630/http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b|archive-date=2 December 2013|df=}}</ref>
<!-- Chemical and physical data -->|C=21|H=25|N=3|O=2|S=1|smiles=N\1=C(\c3c(Sc2c/1cccc2)cccc3)N4CCN(CCOCCO)CC4|StdInChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChIKey=URKOMYMAXPYINW-UHFFFAOYSA-N|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}|solubility=3.29}}
'''QuetiapineKuetiapin''' adalah obat antipsikotik atipikal yang digunakan untuk mengatasi [[skizofrenia]], [[gangguan bipolar]], dan [[gangguan depresi mayor]] . <ref name="AHFS2017">{{Cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017}}</ref> <ref name="Cochrane2010">{{Cite journal|date=December 2010|title=Second-generation antipsychotics for major depressive disorder and dysthymia|journal=The Cochrane Database of Systematic Reviews|issue=12|pages=CD008121|doi=10.1002/14651858.CD008121.pub2|pmid=21154393|vauthors=Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S}}</ref> Walaupun obat ini sering digunakan untuk obat tidur disebabkan efeknya yang menenangkan, walaupun sebenarnya hal ini tidak melebihi efek samping obat ini. <ref>{{Cite journal|date=March 2014|title=Quetiapine for insomnia: A review of the literature|url=http://pdfs.semanticscholar.org/8812/afd4bc713c03435b68f2bb6ea456c611b0b2.pdf|journal=American Journal of Health-System Pharmacy|volume=71|issue=5|pages=394–402|doi=10.2146/ajhp130221|pmid=24534594|archive-url=https://web.archive.org/web/20200219013637/https://pdfs.semanticscholar.org/8812/afd4bc713c03435b68f2bb6ea456c611b0b2.pdf|archive-date=2020-02-19|access-date=2020-05-04|vauthors=Anderson SL, Vande Griend JP|url-status=dead}}</ref> Rute pemberian obat ini melalui oral. <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref>
Efek samping yang umum juga muncul seperti rasa mengantuk, [[sembelit]], berat badan bertambah, dan juga [[xerostomia]] . <ref name="AHFS2017">{{Cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/quetiapine-fumarate.html "Quetiapine Fumarate"]. The American Society of Health-System Pharmacists. [https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html Archived] from the original on 29 August 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">26 March</span> 2017</span>.</cite></ref> Efek samping lainnya dari obat ini yakni bisa meningkatkan [[hipotensi ortostatik]], [[Sawan|kejang]], [[priapisme]], [[hiperglikemia]], tardive dyskinesia, dan sindrom neuroleptik maligna . <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref> Pada lanjut usia dengan kondisi [[demensia]], penggunaan obat ini bisa meningkatkan risiko kematian. <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref> Penggunaan pada [[kehamilan]] [[Kehamilan|trimester ketiga]] bisa menyebabkan gangguan pergerakan pada bayi selama beberapa waktu setelah melahirkan. <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref>Mekanisme kerja obat ini dengan cara memblokir sejumlah reseptor termasuk [[Reseptor serotonin|serotonin]] dan dopamin . <ref name="AHFS2017">{{cite web|title=Quetiapine Fumarate|url=https://www.drugs.com/monograph/quetiapine-fumarate.html|publisher=The American Society of Health-System Pharmacists|access-date=26 March 2017|url-status = live|archive-url=https://web.archive.org/web/20170829153057/https://www.drugs.com/monograph/quetiapine-fumarate.html|archive-date=29 August 2017|df=}}</ref>
== Referensi ==
[[Kategori:ObatHipnotik]]
[[Kategori:FarmasiAntidepresan]]
[[Kategori:Penghalang alfa-1]]
[[Kategori:Penghalang alfa-2]]
[[Kategori:Antipsikotik atipikal]]
[[Kategori:Obat yang dikembangkan oleh AstraZeneca]]
[[Kategori:Dibenzotiazepina]]
[[Kategori:Eter glikol]]
[[Kategori:Antagonis reseptor H1]]
[[Kategori:Antagonis 5-HT2A]]
[[Kategori:Piperazina]]
[[Kategori:Alkohol primer]]
[[Kategori:Sedatif]]
[[Kategori:Obat Esensial Organisasi Kesehatan Dunia]]
<references />{{Farmasi-stub}}
| 