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Revisi per 8 Februari 2024 08.50 sunting WanaraLima (bicara \| kontrib) 1.730 suntingan Artikel baru tentang topik farmasi yang masih memerlukan tambahan dan pengembangan. Artikel ini merupakan terjemahan wikipedia bahasa Inggris masih perlu ditinjau ulang juga disesuaikan dengan padanan bahasa Indonesia Tag: VisualEditor ← Revisi sebelumnya		Revisi terkini sejak 19 Agustus 2024 13.32 sunting balikkan AABot (bicara \| kontrib) Bot, Pengecualian blokir IP 914.197 suntingan k Bot: Mengganti kategori yang dialihkan Penenang otot menjadi Relaksan otot Tag: paws [2.2]
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Baris 17: <!-- Clinical data -->\|pregnancy_AU=\|pregnancy_US=\|pregnancy_category=Category B<ref>{{cite web \|title=Cyclobenzaprine Use During Pregnancy \|url=https://www.drugs.com/pregnancy/cyclobenzaprine.html \|website=Drugs.com \|accessdate=8 January 2020 \|archive-date=2 June 2019 \|archive-url=https://web.archive.org/web/20190602051714/https://www.drugs.com/pregnancy/cyclobenzaprine.html \|url-status=live }}</ref>\|routes_of_administration=[[oral administration\|By mouth]]\|Drugs.com={{drugs.com\|monograph\|cyclobenzaprine}}\|MedlinePlus=a682514 <!-- Legal data -->\|legal_status=rx-only\|licence_US=\|licence_EU=<!-- Pharmacokinetic data -->\|bioavailability=33–55%<ref>Micromedex® 2010 – DRUGDEX Evaluations (Cyclobenzaprine Hydrochloride)</ref><ref>{{cite web \|url = http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=18929 \|title = Cyclobenzaprine Hydrochloride Tablets USP Revised: April 2005 Rx only \|work = nih.gov \|access-date = 1 October 2016 \|archive-date = 21 April 2016 \|archive-url = https://web.archive.org/web/20160421183526/https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=18929 \|url-status = live }}</ref>\|protein_bound=93%\|metabolism=Major: [[CYP3A4]], [[CYP1A2]]; Minor: [[CYP2D6]], [[Demethylation\|N-demethylation]]<ref name="autogen1">{{cite web\|url=https://www.amrix.com/Content/Pdf/prescribing-information.pdf\|date=May 2016\|title=AMR40470 (Amrix) Prescribing Information\|author=Teva Pharmaceuticals USA, Inc\|access-date=2 February 2017\|archive-date=22 December 2016\|archive-url=https://web.archive.org/web/20161222030052/http://www.amrix.com/Content/Pdf/prescribing-information.pdf\|url-status=live}}</ref>\|elimination_half-life=32 hours (range 8–37 hours)<ref~~>{{cite~~ ~~web\|url~~name=~~https://www.amrix.com/Content/Pdf/prescribing-information.pdf\|date=May~~"autogen1" ~~2016\|title=AMR40470 (Amrix) Prescribing Information\|author=Teva Pharmaceuticals USA, Inc\|access-date=2 February 2017\|archive-date=22 December 2016\|archive-url=https:~~/~~/web.archive.org/web/20161222030052/http://www.amrix.com/Content/Pdf/prescribing-information.pdf\|url-status=live}}</ref~~>\|excretion=Kidney <!-- Chemical and physical data -->\|C=20\|H=21\|N=1\|smiles=c3cc\2c(\C=C/c1c(cccc1)C/2=C/CCN(C)C)cc3\|StdInChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3\|StdInChI_Ref={{stdinchicite\|correct\|chemspider}}\|StdInChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N\|StdInChIKey_Ref={{stdinchicite\|correct\|chemspider}}}} '''Siklobenzaprin ('''''Cyclobenzaprine)'' adalah [[obat]] yang digunakan untuk mengatasi [[Spasmofili\|kejang otot]] yang disebabkan keadaan muskuloskeletal yang terjadi spontan. <ref name="AHFS2018">{{Cite web\|title=Cyclobenzaprine Monograph for Professionals\|url=https://www.drugs.com/monograph/cyclobenzaprine.html\|website=Drugs.com\|publisher=AHFS\|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html\|archive-date=23 December 2018\|access-date=22 December 2018\|url-status=live}}</ref> Obat ini tidak memiliki manfaat pada kondisi [[Lumpuh otak\|Cerebral Palsy]] . <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> Rute minum obat secara oral. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> Tidak direkomendasikan untuk pengobatan lebih dari beberapa minggu. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> Efek samping pada obat ini secara umum kejadian [[sakit kepala]], rasa lelah, pusing, dan mulut kering. <ref name="AHFS2018"~~>{{Cite~~ ~~web\|title=Cyclobenzaprine Monograph for Professionals\|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html\|website=Drugs.com\|publisher=AHFS\|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html\|archive-date=23 December 2018\|access-date=22 December 2018\|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/cyclobenzaprine.html "Cyclobenzaprine Monograph for Professionals"]. </cite></ref> Efek samping serius pada obat ini mungkin timbulnya [[aritmia]] . <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> Tidak ada bukti berbahaya pada penggunaan ibu hamil, namun hal ini masih belum diteliti dengan baik pada populasi yang besar. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> Obat ini tidak ~~direkomendarikan~~direkomendasikan digunakan bersama dengan obat golongan inhibitor MAO . <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> Mekanisme kerja pada obat ini belum diketahui secara jelas. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Cyclobenzaprine Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/cyclobenzaprine.html \|website=Drugs.com \|publisher=AHFS \|access-date=22 December 2018 \|archive-date=23 December 2018 \|archive-url=https://web.archive.org/web/20181223073516/https://www.drugs.com/monograph/cyclobenzaprine.html \|url-status=live }}</ref> == Referensi == [[Kategori:Obat]]▼ [[Kategori:Farmasi]]▼ <references />{{Farmasi-stub}} ▲[[Kategori:~~Farmasi~~Dibenzosikloheptena]] [[Kategori:Senyawa dimetilamino]] [[Kategori:Obat dengan cara kerja yang belum diketahui]] [[Kategori:Antagonis muskarinik]] ▲[[Kategori:~~Obat~~Relaksan otot]] [[Kategori:Obat yang dikembangkan oleh Johnson & Johnson]]