Amfoterisin B: Perbedaan antara revisi

<span data-segmentid="380" class="cx-segment">Amfoterisin B berikatan dengan [[ergosterol]], komponen membran sel jamur. Setelah itu, amfoterisin B membentuk pori-pori yang menyebabkan kebocoran [[Valensi|ion monovalen]] dengan cepat ([[Kalium|K⁺]], [[Natrium|Na⁺]], [[Hidrogen|H⁺]] dan [[Klorida|Cl^-]]), sehingga menyebabkan kematian sel jamur.</span> Mekaninsme tersebut merupakan mekanisme <span data-segmentid="387" class="cx-segment">utama amfoterisin B sebagai antijamur.<ref name=":3">{{Cite journal|last=Mesa-Arango|first=Ana Cecilia|last2=Scorzoni|first2=Liliana|last3=Zaragoza|first3=Oscar|date=2012-01-01|title=It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug|journal=Fungi and Their Interactions|volume=3|pages=286|doi=10.3389/fmicb.2012.00286|pmc=3441194|pmid=23024638}}</ref><ref name="O'Keeffe">{{Cite journal|last=O'Keeffe|first=Joseph|last2=Doyle|first2=Sean|last3=Kavanagh|first3=Kevin|date=2003-12-01|title=Exposure of the yeast Candida albicans to the anti-neoplastic agent adriamycin increases the tolerance to amphotericin B|journal=Journal of Pharmacy and Pharmacology|volume=55|issue=12|pages=1629–1633|doi=10.1211/0022357022359|issn=2042-7158|pmid=14738588}}</ref></span> <span data-segmentid="388" class="cx-segment">Kompleks amfoterisin B/ergosterol yang membentuk pori-pori tersebut bersifat stabil karena adanya interaksi Van der Waals.<ref>{{Cite journal|title=Molecular modelling of amphotericin B-ergosterol primary complex in water II|journal=Biophysical Chemistry|volume=141}}</ref></span> <span data-segmentid="389" class="cx-segment">Amfoterisin B juga menyebabkan [[stres oksidatif]] dalam sel jamur,<ref name="Baginski20092">{{Cite journal|last=Baginski|first=M.|last2=Czub|first2=J.|year=2009|title=Amphotericin B and Its New Derivatives–Mode of Action|journal=Current Drug Metabolism|volume=10|issue=5|pages=459–69|doi=10.2174/138920009788898019|pmid=19689243}}</ref> tetapi masih belum diketahui sejauh mana stres oksidatif ini mempengaruhi efektivitas obat.<ref name=":3" /></span>  

[[Kategori:Anti jamurAntijamur]]