Antiperadangan nonsteroid: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
←Membuat halaman berisi ' '''Obat anti-inflamasi nonsteroid''' (OAINS (atau ''Nonsteroidal anti-inflammatory drugs'' (NSAIDs)) kelas obat yang sama-sama memberikan efek analgesik (antinyeri) d...' |
Tidak ada ringkasan suntingan Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
||
| (29 revisi perantara oleh 9 pengguna tidak ditampilkan) | |||
Baris 1:
{{Infobox drug class
|Name = Antiperadangan nonsteroid
|Image = 200mg ibuprofen tablets.jpg
|Alt =
|Caption = Tablet salut selaput 200 mg [[ibuprofen]] generik, obat antiinflamasi nonsteroid yang umum
|Pronounce= {{IPAc-en|ˈ|ɛ|n|s|ɛ|d}} {{respell|EN|sed}}
|Synonyms = {{plainlist}}
* Penghambat siklooksigenase<ref name="stat">{{Citation |last1=Ghlichloo |first1=Ida |title=Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) |date=1 May 2023 |work=StatPearls |url=http://www.ncbi.nlm.nih.gov/books/NBK547742/ |access-date=2024-03-31 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31613522 |last2=Gerriets |first2=Valerie |archive-date=23 April 2024 |archive-url=https://web.archive.org/web/20240423114005/https://ncbi.nlm.nih.gov/books/NBK547742/ |url-status=live }}</ref>
* Penghambat enzim siklooksigenase<ref name=stat/>
* Agen antiinflamasi nonsteroid/analgesik
{{endplainlist}}
<!-- Class identifiers -->
|Use = [[Analgesik]],<ref name=OED/> [[antipiretik]],<ref name=OED/> [[antiinflamasi]],<ref name=OED/> [[antitrombotik]]{{Citation needed|date=February 2022}}
|ATC_prefix = M01A
|Mode_of_action =
|Biological_target = [[COX-1]] and [[COX-2]]
|Mechanism_of_action= [[Inhibitor enzim]]
|Chemical_class =
<!-- Clinical data -->
|Drugs.com = <!-- {{Drugs.com|drug-class|?}} -->
|Consumer_Reports=
|medicinenet =
|rxlist =
<!-- External links -->
|MeshID =
}}
'''
==
OAINS dapat diklasifikasikan berdasarkan struktur kimianya atau mekanisme aksi. OAINS lebih tua dikenal jauh sebelum mekanisme aksi mereka itu dijelaskan dan untuk alasan ini diklasifikasikan oleh struktur atau asal kimia. Zat baru lebih sering diklasifikasikan berdasarkan mekanisme aksi.
=== Salisilat ===
{{colbegin||25em}}
* [[Aspirin]] ([[asam asetilsalisilat]])
* [[Diflunisal]] (Dolobid)
* [[Asam salisilat]] dan salisilat lainnya
* [[Salsalate]] (Disalcid)
{{colend}}
=== Turunan asam propionat ===
{{colbegin||25em}}
* [[Ibuprofen]]<ref name="urlDrugBank: Ibuprofen (DB01050)">{{cite web | url = http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=APRD00372 | title =Ibuprofen | format = | work = DB01050 | publisher = DrugBank }}</ref>
* [[Deksibuprofen]]
* [[Naproksen]]
* [[Fenoprofen]]
* [[Ketoprofen]]
* [[Deksketoprofen]]
* [[Flurbiprofen]]
* [[Oksaprozin]]
* [[Loksoprofen]] (Loxonin), tersedia di Jepang.
{{colend}}
=== Turunan asam asetat ===
{{colbegin||25em}}
* [[Indometasin]]
* [[Tolmetin]]
* [[Sulindak]]
* [[Etodolak]]
* [[Ketorolak]]
* [[Diklofenak]]
* [[Aseklofenak]]
* [[Nabumeton]]
{{colend}}
=== Turunan asam enolat (Oksikam) ===
{{colbegin||25em}}
* [[Piroksikam]]
* [[Meloksikam]]
* [[Tenoksikam]]
* [[Droksikam]]
* [[Lornoksikam]]
* [[Isoksikam]] (ditarik dari pasar tahun 1985<ref>''Consolidated List of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by Governments'', United Nations, 2003, p. 123 [http://apps.who.int/medicinedocs/en/m/abstract/Js16780e/ link to 2005 ed]</ref><ref>{{cite journal|last=Fung|first=M.|author2=Thornton, A. |author3=Mybeck, K. |author4=Wu, J. H.-h. |author5=Hornbuckle, K. |author6= Muniz, E. |title=Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999|journal=[[Therapeutic Innovation & Regulatory Science]]|date=1 January 2001|volume=35|issue=1|pages=293–317|doi=10.1177/009286150103500134}}</ref>)
* [[Fenilbutazon]] (Bute)
{{colend}}
=== Turunan asam antranilat (Fenamat) ===
OAINS berikut adalah turunan dari [[asam fenamat]] yang merupakan turunan dari [[asam antranilat]],<ref name=Sriram>Sriram D, Yogeeswari P. [https://books.google.com/books?id=tUSLclf_NoQC&pg=PA235 Medicinal Chemistry, 2nd Edition]. Pearson Education India, 2010. ISBN 9788131731444</ref>{{rp|235}} yang pada gilirannya adalah nitrogen [[isoster]] dari [[asam salisilat]]<ref name=Sriram/>{{rp|235}}<ref>Auburn University course material. Jack DeRuiter, Principles of Drug Action 2, Fall 2002 1: [http://www.auburn.edu/~deruija/nsaids_2002.pdf Non-Steroidal Antiinflammatory Drugs (NSAIDS)]</ref>{{rp|17}}
{{colbegin||25em}}
* [[Asam mefenamat]]
* [[Asam meklofenamat]]
* [[Asam flufenamat]]
* [[Asam tolfenamat]]
{{colend}}
=== Penghambat siklooksigenase-2 selektif ([[koksib]]) ===
{{colbegin||25em}}
* [[Selekoksib]] (Perhatian FDA<ref>Information for Healthcare Professionals: Celecoxib (marketed as Celebrex) http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124655.htm</ref>)
* [[Rofekoksib]] (ditarik dari pasar<ref name="urlFDA Public Health Advisory: Safety of Vioxx">{{cite web | url = http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm106274.htm | title = Safety of Vioxx | work = FDA Public Health Advisory | publisher = United States Food and Drug Administration }}</ref>)
* [[Valdekoksib]] (ditarik dari pasar<ref>[http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124649.htm Alert for Healthcare Professionals: Valdecoxib (marketed as Bextra)]</ref>)
* [[Parekoksib]] ditarik FDA, berlisensi di EU
* [[Lumirakoksib]] pendaftaran dibatalkan TGA (Australia)
* [[Etorikoksib]] tidak disetujui FDA, berlisensi di EU
* [[Firocoxib]] digunakan pada anjing dan kuda
{{colend}}
=== Sulfonanilid ===
* [[Nimesulid]] (sediaan sistemik dilarang oleh beberapa negara karena potensi risiko hepatotoksisitas)
=== Lainnya ===
* [[Kloniksin]]
* [[Likofelon]] beraksi dengan menghambat LOX (lipooksigenase) & COX dan karenanya dikenal sebagai 5-LOX/COX inhibitor
* H-harpagide dalam ''[[Scrophularia|Figwort]]''<ref name="pmid22414102">{{cite journal |vauthors=Viljoen A, Mncwangi N, Vermaak I | title = Anti-inflammatory iridoids of botanical origin | journal = Curr. Med. Chem. | volume = 19 | issue = 14 | pages = 2104–27 | year = 2012 | pmid = 22414102 | pmc = 3873812 | doi = 10.2174/092986712800229005 }}</ref> atau ''[[Harpagophytum|Devil's Claw]]''<ref name="pmid21775152">{{cite journal |vauthors=Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y | title = Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro | journal = Bioorg. Med. Chem. | volume = 19 | issue = 16 | pages = 4882–6 | year = 2011 | pmid = 21775152 | doi = 10.1016/j.bmc.2011.06.069 }}</ref>
{{colend}}
== Referensi ==
{{reflist}}
{{Obat antiinflamasi nonsteroid}}
[[Kategori:Antiperadangan nonsteroid| ]]
| |||