Antiperadangan nonsteroid: Perbedaan antara revisi

'''Obat anti-inflamasiAntiperadangan nonsteroid''', (OAINSBahasa (atauInggris: '''''Nonsteroidal anti-inflammatory drugs''''', (disingkat '''NSAIDs''') atau '''obat antiinflamasi nonsteroid'''<ref name=OED>{{Cite web|title=non-steroidal anti-inflammatory drug|url=https://www.lexico.com/definition/non-steroidal_anti-inflammatory_drug|website=www.Lexico.com|publisher=[[Oxford English Dictionary]]|date=2022|access-date=4 February 2022|archive-date=5 February 2022|archive-url=https://web.archive.org/web/20220205104155/https://www.lexico.com/definition/non-steroidal_anti-inflammatory_drug|url-status=dead}}</ref> (disingkat '''OAINS''') adalah kelas obat yang sama-sama memberikan efek analgesik (antinyeri) dan antipiretik (penurun panas), dandalamdan dalam dosis yang lebih tinggi berefek efek anti-inflamasi. Istilah "nonsteroid" membedakan obat ini dari atinanti-inflamasi lain yaitu "[[steroid]]", yang bekerja menekan produksi [[eikosanoid]]. Istilah ini pertama kali digunakan pada tahun 1960, digunakan untuk menjauhkan obat baru dari tragedi [[iatrogenik]] terkait steroid.<ref name="Buer_2014">{{cite journal | vauthors = Buer JK | title = Origins and impact of the term 'NSAID' | journal = Inflammopharmacology | volume = 22 | issue = 5 | pages = 263–7 | date = Oct 2014 | url = https://www.researchgate.net/publication/264248818_Origins_and_impact_of_the_term_'NSAID' | pmid = 25064056 | doi = 10.1007/s10787-014-0211-2 }}</ref>

== Klasifikasi ==

* [[Nabumeton]]

TheOAINS followingberikut NSAIDsadalah areturunan derived fromdari [[fenamicasam acidfenamat]]. which isyang amerupakan derivativeturunan ofdari [[anthranilicasam acidantranilat]],<ref name=Sriram>Sriram D, Yogeeswari P. [https://books.google.com/books?id=tUSLclf_NoQC&pg=PA235 Medicinal Chemistry, 2nd Edition]. Pearson Education India, 2010. ISBN 9788131731444</ref>{{rp|235}} whichyang inpada turngilirannya is aadalah nitrogen [[isostereisoster]] ofdari [[salicylicasam acidsalisilat]], which is the [[active metabolite]] of [[aspirin]].<ref name=Sriram/>{{rp|235}}<ref>Auburn University course material. Jack DeRuiter, Principles of Drug Action 2, Fall 2002 1: [http://www.auburn.edu/~deruija/nsaids_2002.pdf Non-Steroidal Antiinflammatory Drugs (NSAIDS)]</ref>{{rp|17}}

* [[MefenamicAsam acidmefenamat]]

* [[MeclofenamicAsam acidmeklofenamat]]

* [[FlufenamicAsam acidflufenamat]]

* [[TolfenamicAsam acidtolfenamat]]

=== SelectivePenghambat COXsiklooksigenase-2 inhibitorsselektif ([[Coxibskoksib]]) ===

* [[CelecoxibSelekoksib]] (FDAPerhatian alertFDA<ref>Information for Healthcare Professionals: Celecoxib (marketed as Celebrex) http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124655.htm</ref>)

* [[RofecoxibRofekoksib]] (withdrawnditarik fromdari marketpasar<ref name="urlFDA Public Health Advisory: Safety of Vioxx">{{cite web | url = http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm106274.htm | title = Safety of Vioxx | work = FDA Public Health Advisory | publisher = United States Food and Drug Administration }}</ref>)

* [[ValdecoxibValdekoksib]] (withdrawnditarik fromdari marketpasar<ref>[http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124649.htm Alert for Healthcare Professionals: Valdecoxib (marketed as Bextra)]</ref>)

* [[ParecoxibParekoksib]] ditarik FDA withdrawn, licensed inberlisensi thedi EU

* [[EtoricoxibEtorikoksib]] nottidak disetujui FDA approved, licensed inberlisensi thedi EU

* [[Firocoxib]] useddigunakan inpada dogsanjing anddan horseskuda

=== SulfonanilidesSulfonanilid ===

=== OthersLainnya ===

* [[ClonixinKloniksin]]

* [[LicofeloneLikofelon]] actsberaksi bydengan inhibitingmenghambat LOX (lipooxygenaselipooksigenase) & COX anddan hencekarenanya knowndikenal assebagai 5-LOX/COX inhibitor

* H-harpagide indalam ''[[Scrophularia|Figwort]]''<ref name="pmid22414102">{{cite journal |vauthors=Viljoen A, Mncwangi N, Vermaak I | title = Anti-inflammatory iridoids of botanical origin | journal = Curr. Med. Chem. | volume = 19 | issue = 14 | pages = 2104–27 | year = 2012 | pmid = 22414102 | pmc = 3873812 | doi = 10.2174/092986712800229005 }}</ref> oratau ''[[Harpagophytum|Devil's Claw]]''<ref name="pmid21775152">{{cite journal |vauthors=Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y | title = Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro | journal = Bioorg. Med. Chem. | volume = 19 | issue = 16 | pages = 4882–6 | year = 2011 | pmid = 21775152 | doi = 10.1016/j.bmc.2011.06.069 }}</ref>

== Referensi ==