Laju ekskresi renal: Perbedaan antara revisi
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'''Laju ekskresi renal''' atau '''klirens''' adalah [[kecepatan]] [[ekskresi]] [[organ]] [[ginjal]] yang merupakan fungsi filtrasi glomerulus dan reabsorpsi pada tubula proksimal.<ref>{{en}} {{cite book▼
▲'''Laju ekskresi renal''' adalah [[kecepatan]] [[ekskresi]] [[organ]] [[ginjal]] yang merupakan fungsi filtrasi glomerulus dan reabsorpsi pada tubula proksimal.<ref>{{en}}{{cite book
▲| title = Clinical Methods: The History, Physical, and Laboratory Examinations
▲| author = H Kenneth Walker, MD, W Dallas Hall, MD, and J Willis Hurst, MD.
▲| work = Emory University School of Medicine, Atlanta, Georgia
|edition = 3
▲| isbn = 0-409-90077-X
|
▲| page = Chapter 193 BUN and Creatinine
▲| publisher = Butterworth Publishers, a division of Reed Publishing
|accessdate = 2011-05-11
▲| url = http://www.ncbi.nlm.nih.gov/books/NBK305/#A5449
}}</ref> Konsep ekskresi renal merupakan titik pertemuan antara 3 sub-bidang [[nefrologi]] dan analisis konseptual mula-mula yang mencoba menjabarkan peristiwa terjadinya [[urin]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/15151274
| title = The development of the clearance concept.
| accessdate = 2011-05-11
| work = Department of Internal Medicine, The University of Texas Southwestern Medical School; Seldin DW.
}}</ref> Konsep ini dipergunakan sebagai tolok ukur fungsi ginjal pada eskalasi penyakit renal, dan menjelaskan aspek [[fisiologi]] organ bersangkutan.
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== Laju ekskresi kreatinina ==
In normal subjects, creatinine is excreted primarily by the kidneys. There is minimal extrarenal disposal or demonstrable metabolism. As a small molecule (molecular weight of 113 daltons), it is freely filtered by the glomerulus. Unlike urea, it is not reabsorbed or affected by urine flow rate. It is normally secreted by the tubules in a small but significant amount (up to 10% of total excretion). Excretion of both urea and creatinine is increased during exercise without producing significant change in serum concentration. The total creatinine excretion in a normal man averages 14 to 26 mg/kg/day, and in a normal woman 11 to 20 mg/kg/day. Excretion declines with age, and is about 10 mg/kg/day in a 90-year-old man. However, it should not vary more than 10 to 15% in a given individual. The amount excreted has been used as a rough index of the completeness of daily urine collection.
Measurement of urine creatinine excretion is used in calculating the creatinine clearance (cCr). Short of the more precise but technically impractical inulin clearance, the cCr is the standard clinical tool for estimating GFR, especially in the early stages of renal disease. In that setting sCr and BUN are not very useful indices of GFR due to their parabolic relationship and to the wide range of normal (Figure 193.3).
==Laju ekskresi inulin ==
''Inulin clearance''
== Laju ekskresi asam para-aminohipurat ==
''PAH clearance''
== Laju ekskresi urea ==
''Urea clearance''
== Laju aliran urin ==
''Urine flow rate''
== Laju filtrasi glomerular ==
''Glomerular filtration rate''
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== Rujukan ==
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[[Kategori:Metabolisme]]
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