Etilmorfin: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
←Membuat halaman berisi '{{Short description|Opioid analgesic and antitussive drug}} {{Drugbox | Watchedfields = changed | verifiedrevid = 447189889 | IUPAC_name = 7,8-didehydro-4,5-α-epoxy- 3-ethoxy-17-methylmorphinan-6-α-ol | image = Ethylmorphine.svg | alt = Structural formula | width = 210 | image2 = Ethylmorphine molecule ball.png | alt2 = Ball-and-stick model | width2 = 220 <!--Clinical data--> | tradename = Cosylan, Diolan, Dionina, Diosan, Solvipect, Trachyl | Drugs.com = {{dr...' Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
k Menghapus Kategori:Opioid semisintesis; Menambah Kategori:Opioid semisintetik menggunakan HotCat |
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'''Etilmorfin''' (juga dikenal sebagai '''kodetilin''', '''dionin''', dan '''etil morfin''') adalah [[analgesik]] dan [[antitusif]] [[opioid]].<ref>{{cite journal | vauthors = Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J | title = Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model | journal = Pharmacology & Toxicology | volume = 80 | issue = 4 | pages = 171–81 | date = April 1997 | pmid = 9140136 | doi = 10.1111/j.1600-0773.1997.tb00392.x | doi-access = free }}</ref><ref>{{cite journal | vauthors = Jonasson B, Jonasson U, Holmgren P, Saldeen T | title = Fatal poisonings where ethylmorphine from antitussive medications contributed to death | journal = International Journal of Legal Medicine | volume = 112 | issue = 5 | pages = 299–302 | date = August 1999 | pmid = 10460420 | doi = 10.1007/s004140050253 | s2cid = 24384512 }}</ref><ref>{{cite journal | vauthors = Popa C, Beck O, Brodin K | title = Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine | journal = Journal of Analytical Toxicology | volume = 22 | issue = 2 | pages = 142–7 | date = March–April 1998 | pmid = 9547411 | doi = 10.1093/jat/22.2.142 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Amacher DE, Schomaker SJ | title = Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes | journal = Toxicology Letters | volume = 94 | issue = 2 | pages = 115–25 | date = January 1998 | pmid = 9574808 | doi = 10.1016/S0378-4274(97)00108-2 }}</ref><ref>{{cite journal | vauthors = Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, Bodd E, Mørland J | display-authors = 6 | title = Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose | journal = British Journal of Clinical Pharmacology | volume = 39 | issue = 6 | pages = 611–20 | date = June 1995 | pmid = 7654478 | pmc = 1365072 | doi = 10.1111/j.1365-2125.1995.tb05720.x }}</ref><ref>{{cite journal | vauthors = Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A | title = Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism | journal = British Journal of Clinical Pharmacology | volume = 39 | issue = 1 | pages = 77–80 | date = January 1995 | pmid = 7756104 | pmc = 1364985 | doi = 10.1111/j.1365-2125.1995.tb04413.x }}</ref>
==Efek samping==
Efek sampingnya mirip dengan opioid lain dan meliputi rasa kantuk, sembelit, [[vertigo]], mual, muntah, dan depresi pernapasan. Kontraindikasi meliputi [[asma]], insufisiensi pernapasan, dan usia di bawah 8 tahun. Etilmorfin dapat memengaruhi kemampuan pengguna untuk mengemudi dan mengoperasikan mesin berat, dan dapat menyebabkan ketergantungan atau kecanduan zat kimia pada dosis tinggi.<ref name="DAA">{{cite book |isbn=0-8103-7177-4 |title=Drugs Available Abroad, 1st Edition |date=1991 |page=79 | vauthors = Schlesser JL |publisher=Derwent Publications Ltd.}}</ref>
==Dalam budaya masyarakat==
Etilmorfin pertama kali dipasarkan di Prancis pada tahun 1953 oleh Houde, dan di Norwegia dan Spanyol pada tahun 1960. Obat ini tidak tersedia di Amerika Serikat, karena obat ini merupakan zat yang dikendalikan ''Schedule II''.<ref name="DAA" /><ref>{{Cite web |last=PubChem |title=Ethylmorphine |url=https://pubchem.ncbi.nlm.nih.gov/compound/5359271 |access-date=2023-09-08 |website=pubchem.ncbi.nlm.nih.gov |language=en}}</ref>
== Referensi ==
{{Reflist|2}}
[[Kategori:Alkohol sekunder]]
[[Kategori:Antitusif]]
[[
[[Kategori:Opioid semisintetik]]
[[
[[Kategori:Agonis reseptor mu-opioid]]
[[Kategori:Obat oftalmologi]]
[[Kategori:Senyawa etoksi]]
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