Fluorourasil: Perbedaan antara revisi

| IUPAC_name = 5-fluoro-1''H''-pyrimidinepirimidina-2,4-dionedion

| pregnancy_category = <br>D (intravenousintravena), X (topikal) <small>([[United States|US]])</small>

| legal_US = hanya Rx-only

| routes_of_administration = [[IntravenousTerapi therapyintravena|IntravenousIntravena]] (infus atau [[wikt:bolus|bolus]]) dan topikal

| bioavailability = 28 tohingga 100%

| protein_bound = 8 tohingga 12%

| metabolism = Intraselular dan [[hati|hepatichepatik]] ([[cytochromesitokrom P450|CYP]]-mediatedmediasi)

| elimination_half-life = 10 tohingga 20 minutesmenit

| excretion = [[KidneyGinjal|Renal]]

'''FluorouracilFluorourasil''' ('''5-FU''' oratau '''f5U)''') (dijual dengan merek '''Adrucil, Carac, Efudix, Efudex''' and '''Fluoroplex''') adalah [[obat farmasi|obat]] dari analog pyrimidinepirimidina yang digunakan untuk perawatan [[kanker]]. Adalah ''"penghambat bunuh diri" ''(''suicide inhibition'') yang bekerja melalaui penghambatan dari [[thymidylatetimidilat synthasesintase]]. Masuk dalam kelompok obat-obatan yang disebudisebut [[antimetaboliteantimetabolit]]. Umumnya digunakan ersamabersama [[leucovorinleukovorin]].

Trissel and colleagues have shown that 5-FU and leucovorin are physically incompatible when mixed in portable-pump reservoirs. <ref>{{cite journal |author=Trissel LA, Martinez JF, Xu QA |title=Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium |journal=Am J Health Syst Pharm |volume=52 |issue=7 |pages=710–5 |year=1995 |month=April |pmid=7627739 }}</ref> Similarly, infusion of 5-FU and leucovorin via permanent indwelling catheters is complicated by catheter blockage due to calcium carbonate formation (Ardalan and Flores, 1995). <ref>{{cite journal |author=Ardalan B, Flores MR |title=A new complication of chemotherapy administered via permanent indwelling central venous catheter |journal=Cancer |volume=75 |issue=8 |pages=2165–8 |year=1995 |month=April |pmid=7697607 |doi=10.1002/1097-0142(19950415)75:8<2165::AID-CNCR2820750821>3.0.CO;2-W }}</ref>

== Referensi ==

* {{en}} [http://www.cancerbackup.org.uk/Treatments/Chemotherapy/Individualdrugs/Fluorouracil Cancerbackup.org.uk &ndash;– Fluorouracil's use in cancer] {{Webarchive|url=https://web.archive.org/web/20081216011012/http://www.cancerbackup.org.uk/Treatments/Chemotherapy/Individualdrugs/Fluorouracil |date=2008-12-16 }}

[[Kategori:OrganofluoridaFluoropirimidina]]

[[Kategori:PirimidinaAntagonis pirimidina]]

[[Kategori:KetonPirimidinadiona]]