Klonazepam: Perbedaan antara revisi
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| pronounce = kləˈnazɪpam, kloe-NAZ-e-pam
| tradename = Klonopin, Rivotril, Paxam,<ref name="Paxam_Data_Sheet">{{Cite web |title=Paxam Data Sheet |date=October 18, 2023 |url=https://www.medsafe.govt.nz/profs/datasheet/p/Paxamtab.pdf |access-date=March 14, 2024 |website=medsafe.govt.nz |archive-date=9 December 2023 |archive-url=https://web.archive.org/web/20231209033635/https://www.medsafe.govt.nz/profs/datasheet/p/Paxamtab.pdf |url-status=live }}</ref>
| Drugs.com = {{drugs.com|monograph|clonazepam}}
| MedlinePlus = a682279
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| pregnancy_AU_comment = <ref name="Drugs.com pregnancy">{{cite web | title=Clonazepam Use During Pregnancy | website=Drugs.com | date=4 May 2020 | url=https://www.drugs.com/pregnancy/clonazepam.html | access-date=17 May 2020 | archive-date=28 July 2020 | archive-url=https://web.archive.org/web/20200728161048/https://www.drugs.com/pregnancy/clonazepam.html | url-status=live }}</ref>
| pregnancy_category =
| dependency_liability = Ketergantungan fisik: Sangat Tinggi [[
| addiction_liability = Moderate<ref name="longo2000">{{cite journal | vauthors = Longo LP, Johnson B | title = Addiction: Part I. Benzodiazepines--side effects, abuse risk and alternatives | journal = American Family Physician | volume = 61 | issue = 7 | pages = 2121–2128 | date = April 2000 | pmid = 10779253 | url = https://www.aafp.org/pubs/afp/issues/2000/0401/p2121.html | access-date = 11 December 2022 | archive-date = 12 May 2008 | archive-url = https://web.archive.org/web/20080512180747/http://www.aafp.org/afp/20000401/2121.html | url-status = live }}</ref><ref>{{cite book | vauthors = Hupp JR, Tucker MR, Ellis E |title=Contemporary Oral and Maxillofacial Surgery - E-Book |date=2013 |publisher=Elsevier Health Sciences |isbn=9780323226875 |page=679 |url=https://books.google.com/books?id=RcbsAwAAQBAJ&pg=PA679 }}</ref>
| routes_of_administration = [[Oral
| class = [[Benzodiazepine]]
| ATC_prefix = N03
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<!-- Pharmacokinetic data -->| bioavailability = 90%
| protein_bound = ≈85%
| metabolism = [[Hati]] ([[CYP3A]])<ref name="AHFS2015">{{cite web |title=Clonazepam |url=https://www.drugs.com/monograph/clonazepam.html |publisher=The American Society of Health-System Pharmacists |access-date=15 August 2015 |url-status=live |archive-url=https://web.archive.org/web/20150905085907/http://www.drugs.com/monograph/clonazepam.html |archive-date=5 September 2015 }}</ref>
| metabolites = 7-aminoclonazepam<br>
7-acetaminoclonazepam<br>3-hydroxy clonazepam<ref name="auto">{{cite journal | vauthors = Ebel S, Schütz H | title = [Studies on the detection of clonazepam and its main metabolites considering in particular thin-layer chromatography discrimination of nitrazepam and its major metabolic products (author's transl)] | journal = Arzneimittel-Forschung | volume = 27 | issue = 2 | pages = 325–337 | date = February 1977 | pmid = 577149 }}</ref><ref>{{cite journal | vauthors = Steentoft A, Linnet K | title = Blood concentrations of clonazepam and 7-aminoclonazepam in forensic cases in Denmark for the period 2002-2007 | journal = Forensic Science International | volume = 184 | issue = 1–3 | pages = 74–79 | date = January 2009 | pmid = 19150586 | doi = 10.1016/j.forsciint.2008.12.004 }}</ref>
| onset = Within an hour<ref name=Coop2007/>
| elimination_half-life = 19–60 jam<ref name="Riss-2008">{{cite journal | vauthors = Riss J, Cloyd J, Gates J, Collins S | title = Benzodiazepines in epilepsy: pharmacology and pharmacokinetics | journal = Acta Neurologica Scandinavica | volume = 118 | issue = 2 | pages = 69–86 | date = August 2008 | pmid = 18384456 | doi = 10.1111/j.1600-0404.2008.01004.x | s2cid = 24453988 | doi-access = }}{{cbignore|bot=medic}}</ref>
| duration_of_action = 8–12 hours<ref name=Coop2007/><ref name="Paxam_Data_Sheet" />
| excretion = [[
<!-- Identifiers -->| CAS_number_Ref = {{cascite|correct|??}}
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| PDB_ligand =
| synonyms = <!-- Chemical and physical data -->
| IUPAC_name = 5-(2-
| C = 15
| H = 10
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'''Klonazepam''', atau dikenal juga dengan nama dagangnya '''Klonopin'''<ref>[https://reference.medscape.com/drug/klonopin-clonazepam-342900 ''Klonopin/Clonazepan''.] dari situs medscape</ref> atau '''[[Riklona]]'''<ref>[https://www.klikdokter.com/obat/obat-gangguan-saraf-pusat/riklona ''Riklona''.] dari situs klikdokter</ref>, merupakan obat yang digunakan untuk mencegah dan mengobati kejang, gangguan panik, dan gangguan gerak yang dikenal dengan akathisia.<ref>[https://www.drugs.com/monograph/clonazepam.html ''Clonazepam (monograph)''.] dari situs drugs.com</ref> Obat ini adalah jenis obat penenang dari kelas benzodiazepin.<ref name=alodokter>[https://www.alodokter.com/clonazepam#:~:text=Clonazepam%20merupakan%20obat%20antikejang%20golongan,aktivitas%20listrik%20otak%20yang%20berlebihan. ''Clonazepam''.] dari situs alodokter</ref> Konsumsinya dengan diminum.<ref>[https://www.halodoc.com/kesehatan/clonazepam ''Clonazepam''.] dari situs Halodoc.com</ref> Bioavailabilitas dari clonazepam adalah 90% dengan waktu menuju konsentrasi plasma puncak adalah 1-4 jam. Waktu paruh clonazepam diperkirakan sekitar 25 menit. Awitan clonazepam biasanya mulai dalam 20-60 menit sebagai antikejang, dengan durasi aksi 6-8 jam pada bayi dan anak serta hingga 12 jam pada dewasa.<ref>[https://www.alomedika.com/obat/antiepilepsi-antikonvulsi/benzodiazepin/clonazepam/farmakologi ''Farmakologi Clonazepam''.] dari situs alomedika</ref>
==Efek samping==
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==Referensi==
{{reflist|3}}
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