Insulin aspart: Perbedaan antara revisi
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| image = Insulin Aspart Structural Formula.gif
| alt = <!-- Clinical data -->
| tradename = Sansulin, NovoLog, NovoRapid, Fiasp, dll
| Drugs.com = {{drugs.com|monograph|insulin_aspart}}
| MedlinePlus = a605013
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==Kegunaan dalam medis==
Insulin aspart diindikasikan untuk meningkatkan kontrol glikemik pada penderita [[diabetes melitus]].<ref name="Fiasp FDA label">{{cite web | title=Fiasp- insulin aspart injection injection, solution | website=DailyMed | date=19 December 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=834e7efc-393f-4c55-9125-628562a8a5cf | access-date=12 November 2020 | archive-date=13 November 2020 | archive-url=https://web.archive.org/web/20201113025955/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=834e7efc-393f-4c55-9125-628562a8a5cf | url-status=live }}</ref><ref name="NovoLog FDA label">{{cite web | title=NovoLog- insulin aspart injection, solution Insulin Diluting Medium For NovoLog- water injection injection, solution | website=DailyMed | date=15 November 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5 | access-date=12 November 2020 | archive-date=12 November 2020 | archive-url=https://web.archive.org/web/20201112193904/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5 | url-status=live }}</ref>
===Onset aksi===
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===Variasi===
NovoLog Mix 70/30 adalah produk yang mengandung 30% insulin aspart dan 70% insulin aspart protamin. Bagian insulin aspart protamin adalah bentuk kristal insulin aspart, yang menunda aksi insulin, sehingga memberikan profil penyerapan yang lebih lama setelah injeksi.<ref name="NovoLog Mix FDA label">{{cite web | title=NovoLog Mix 70/30- insulin aspart injection, suspension | website=DailyMed | date=15 November 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1861fcee-7673-4afe-a206-08fa05c0add2 | access-date=12 November 2020 | archive-date=29 September 2020 | archive-url=https://web.archive.org/web/20200929013529/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1861fcee-7673-4afe-a206-08fa05c0add2 | url-status=live }}</ref> Kombinasi bentuk kerja cepat dan bentuk kerja lama memungkinkan pasien menerima lebih sedikit suntikan sepanjang hari.<ref>{{cite web | work = Rx List | title = NovoLog Mix 70/30 | date = 6 August 2008 | url = http://www.rxlist.com/novolog-mix-70-30-drug.htm | archive-url = https://web.archive.org/web/20090420190334/http://www.rxlist.com/novolog-mix-70-30-drug.htm | archive-date = 20 April 2009 }}</ref>
NovoLog Mix dipasarkan untuk digunakan dengan [[Novo Nordisk]] FlexPen.<ref>{{cite web | work = Novo Nordisk | title = NovoLog Mix 70/30 | date = 2008 | url = http://www.novologmix70-30.com/starting-with-novolog-mix.asp | archive-url = https://web.archive.org/web/20090508145759/http://www.novologmix70-30.com/starting-with-novolog-mix.asp | archive-date = 8 May 2009 }}</ref> Onset aksinya kurang dari 30 menit, aksi puncaknya tercapai dalam 1–4 jam, dan durasinya kurang dari 24 jam.<ref name="Pharmaceutical Biotechnology">{{cite book | vauthors = Beals JM, DeFelippis MR, Kovach PM | chapter = Insulin | veditors = Crommelin DJ, Sindelar RD, Meibohm B | date = 2008 | title = Pharmaceutical Biotechnology: Fundamentals and Applications. | location = New York, NY | publisher = Informa Healthcare USA, Inc. | page = 265–280 (270) | isbn = 978-1-4200-4437-9 }}</ref> NovoLog Mix dipasarkan di beberapa negara sebagai NovoMix 30.<ref>{{cite web | title=NovoMix 30 FlexPen 100 units/ml - Summary of Product Characteristics (SmPC) | website=(emc) | date=27 March 2019 | url=https://www.medicines.org.uk/emc/product/1600/smpc | access-date=12 April 2020 | archive-date=13 April 2020 | archive-url=https://web.archive.org/web/20200413050707/https://www.medicines.org.uk/emc/product/1600/smpc | url-status=live }}</ref><ref name="NovoMix EPAR">{{cite web | title=NovoMix EPAR | website=[[European Medicines Agency]] (EMA) | date=17 September 2018 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/novomix | access-date=12 April 2020 | archive-date=13 April 2020 | archive-url=https://web.archive.org/web/20200413050741/https://www.ema.europa.eu/en/medicines/human/EPAR/novomix | url-status=live }}</ref>
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==Dalam budaya masyarakat==
Pada tahun 2018, belum ada bukti kuat yang menyimpulkan keunggulan insulin aspart dibandingkan insulin manusia pada diabetes tipe 2.<ref>{{cite journal | vauthors = Fullerton B, Siebenhofer A, Jeitler K, Horvath K, Semlitsch T, Berghold A, Gerlach FM | title = Short-acting insulin analogues versus regular human insulin for adult, non-pregnant persons with type 2 diabetes mellitus | journal = The Cochrane Database of Systematic Reviews | volume = 12 | issue = 12 | pages = CD013228 | date = December 2018 | pmid = 30556900 | pmc = 6517032 | doi = 10.1002/14651858.CD013228 }}</ref> Oleh karena itu, masih belum jelas mengapa orang beralih dari insulin manusia ke insulin aspart.<ref>{{cite journal | vauthors = Cohen D, Carter P | title = How small changes led to big profits for insulin manufacturers | journal = BMJ | volume = 341 | pages = c7139 | date = December 2010 | pmid = 21159773 | doi = 10.1136/bmj.c7139 | s2cid = 30709912 }}</ref> Pada diabetes tipe 1, insulin aspart tampaknya menghasilkan kontrol gula darah yang sedikit lebih baik.<ref>{{cite journal | vauthors = Fullerton B, Siebenhofer A, Jeitler K, Horvath K, Semlitsch T, Berghold A, Plank J, Pieber TR, Gerlach FM | title = Short-acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus | journal = The Cochrane Database of Systematic Reviews | volume = 2016 | issue = 6 | pages = CD012161 | date = June 2016 | pmid = 27362975 | pmc = 6597145 | doi = 10.1002/14651858.CD012161 }}</ref>
== Referensi ==
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