Sibutramina: Perbedaan antara revisi
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| (1 revisi perantara oleh pengguna yang sama tidak ditampilkan) | |||
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{{Infobox drug
| Watchedfields = changed
| class = [[Serotonin–norepinephrine reuptake inhibitor]]; [[Anoretic]]
| verifiedrevid = 464390010
| IUPAC_name = 1-(1-(4-klorofenil)siklobutil)-N,N,2,2-tetrametilpropan-1-amina
| image = Sibutramine.svg
| width = 200px
| image2 = Sibutramine ball-and-stick model.png
| width2 = 200px
| caption = Sibutramin (atas),<br />(''S'')-(−)-sibutramin (bawah)
<!--Clinical data-->| tradename = Meridia, dll
| Drugs.com = {{drugs.com|monograph|sibutramine-hydrochloride}}
| MedlinePlus = a601110
| pregnancy_AU = C
| pregnancy_US = C
| pregnancy_category = Tidak ada data pada manusia; bukti potensi teratogenik yang tidak meyakinkan dalam penelitian pada hewan
| legal_BR = B2
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-03-31 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=2023-08-03 |access-date=2023-08-16 |publisher=[[Diário Oficial da União]] |language=pt-BR |publication-date=2023-04-04}}</ref>
| legal_CA_comment = Withdrawn from market
| legal_US = Schedule IV
| routes_of_administration = [[Oral (rute pemberian obat)|Oral]]
<!--Pharmacokinetic data-->| bioavailability = Penyerapan 77%, metabolisme lintas pertama yang signifikan
| protein_bound = 97%, (94% untuk metabolit desmetilnya, M<sub>1</sub> & M<sub>2</sub>)
| metabolism = [[Hati]] (dimediasi [[CYP3A4]]-mediated)
| elimination_half-life = 1 jam (sibutramin), 14 jam (M<sub>1</sub>) & 16 jam (M<sub>2</sub>)
| excretion = Urin (77%), feses (8%)
<!--Identifiers-->| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 106650-56-0
| CAS_supplemental = <br />{{CAS|766462-77-5}} (klorosibutramin)
| ATC_prefix = A08
| ATC_suffix = AA10
| PubChem = 5210
| IUPHAR_ligand = 2586
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01105
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5021
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = WV5EC51866
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08513
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1419
| synonyms = BTS-54524
<!--Chemical data-->| C = 17
| H = 26
| Cl = 1
| N = 1
| SMILES = ClC1=CC=C(C2(CCC2)C(CC(C)C)N(C)C)C=C1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = UNAANXDKBXWMLN-UHFFFAOYSA-N
}}
'''Sibutramin''' merupakan [[obat]] penekan [[nafsu makan]] yang dijual dengan merek dagang '''Meridia''' atau '''Reductil'''. Hingga tahun 2010, sibutramin dipasarkan secara luas dan diresepkan sebagai obat dalam pengobatan [[Kegemukan|obesitas]].<ref>{{Cite journal|date=2008|title=Sibutramine (Meridia)|url=http://dx.doi.org/10.4135/9781412963862.n421|journal=Encyclopedia of Obesity|location=2455 Teller Road, Thousand Oaks California 91320 United States|publisher=SAGE Publications, Inc.}}</ref> Mekanisme utama obat ini adalah penghambatan pengambilan kembali [[serotonin]] dan [[Noradrenalin|norepinefrin]] pada [[sinapsis]] [[Sel saraf|neuron]] yang menghasilkan efek penurunan asupan energi dan meningkatkan rasa kenyang.<ref>{{Cite journal|last=Lean|first=M. E. J.|date=2001-12|title=How does sibutramine work?|url=https://www.nature.com/articles/0801931|journal=International Journal of Obesity|language=en|volume=25|issue=4|pages=S8–S11|doi=10.1038/sj.ijo.0801931|issn=1476-5497}}</ref>
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