Sibutramina: Perbedaan antara revisi
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{{Infobox drug
| Watchedfields = changed
| class = [[Serotonin–norepinephrine reuptake inhibitor]]; [[Anoretic]]
| verifiedrevid = 464390010
| IUPAC_name = 1-(1-(4-klorofenil)siklobutil)-N,N,2,2-tetrametilpropan-1-amina
| image = Sibutramine.svg
| width = 200px
| image2 = Sibutramine ball-and-stick model.png
| width2 = 200px
| caption = Sibutramin (atas),<br />(''S'')-(−)-sibutramin (bawah)
<!--Clinical data-->| tradename = Meridia, dll
| Drugs.com = {{drugs.com|monograph|sibutramine-hydrochloride}}
| MedlinePlus = a601110
| pregnancy_AU = C
| pregnancy_US = C
| pregnancy_category = Tidak ada data pada manusia; bukti potensi teratogenik yang tidak meyakinkan dalam penelitian pada hewan
| legal_BR = B2
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-03-31 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=2023-08-03 |access-date=2023-08-16 |publisher=[[Diário Oficial da União]] |language=pt-BR |publication-date=2023-04-04}}</ref>
| legal_CA_comment = Withdrawn from market
| legal_US = Schedule IV
| routes_of_administration = [[Oral (rute pemberian obat)|Oral]]
<!--Pharmacokinetic data-->| bioavailability = Penyerapan 77%, metabolisme lintas pertama yang signifikan
| protein_bound = 97%, (94% untuk metabolit desmetilnya, M<sub>1</sub> & M<sub>2</sub>)
| metabolism = [[Hati]] (dimediasi [[CYP3A4]]-mediated)
| elimination_half-life = 1 jam (sibutramin), 14 jam (M<sub>1</sub>) & 16 jam (M<sub>2</sub>)
| excretion = Urin (77%), feses (8%)
<!--Identifiers-->| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 106650-56-0
| CAS_supplemental = <br />{{CAS|766462-77-5}} (klorosibutramin)
| ATC_prefix = A08
| ATC_suffix = AA10
| PubChem = 5210
| IUPHAR_ligand = 2586
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01105
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5021
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = WV5EC51866
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08513
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1419
| synonyms = BTS-54524
<!--Chemical data-->| C = 17
| H = 26
| Cl = 1
| N = 1
| SMILES = ClC1=CC=C(C2(CCC2)C(CC(C)C)N(C)C)C=C1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = UNAANXDKBXWMLN-UHFFFAOYSA-N
}}
'''Sibutramin''' merupakan [[obat]] penekan [[nafsu makan]] yang dijual dengan merek dagang '''Meridia''' atau '''Reductil'''. Hingga tahun 2010, sibutramin dipasarkan secara luas dan diresepkan sebagai obat dalam pengobatan [[Kegemukan|obesitas]].<ref>{{Cite journal|date=2008|title=Sibutramine (Meridia)|url=http://dx.doi.org/10.4135/9781412963862.n421|journal=Encyclopedia of Obesity|location=2455 Teller Road, Thousand Oaks California 91320 United States|publisher=SAGE Publications, Inc.}}</ref> Mekanisme utama obat ini adalah penghambatan pengambilan kembali [[serotonin]] dan [[Noradrenalin|norepinefrin]] pada [[sinapsis]] [[Sel saraf|neuron]] yang menghasilkan efek penurunan asupan energi dan meningkatkan rasa kenyang.<ref>{{Cite journal|last=Lean|first=M. E. J.|date=2001-12|title=How does sibutramine work?|url=https://www.nature.com/articles/0801931|journal=International Journal of Obesity|language=en|volume=25|issue=4|pages=S8–S11|doi=10.1038/sj.ijo.0801931|issn=1476-5497}}</ref>
Di banyak negara, penjualan sibutramin telah dihentikan pada tahun 2010 karena penggunaannya dikaitkan dengan peningkatan kasus [[penyakit kardiovaskular]] dan [[strok]]. Beberapa negara yang menarik sibutramin dari pasar di antaranya adalah Australia,<ref>{{Cite journal|last=&NA;|date=2010-06|title=The Australian Therapeutic Goods Administration (TGA) is reviewing the safety of sibutramine|url=http://dx.doi.org/10.2165/00128415-201013040-00014|journal=Reactions Weekly|volume=&NA;|issue=1304|pages=5|doi=10.2165/00128415-201013040-00014|issn=0114-9954}}</ref> Kanada,<ref>[https://hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/meridia_hpc-cps-eng.php Health Canada Endorsed Important Safety Information on MERIDIA (Sibutramine Hydrochloride Monohydrate)] [https://web.archive.org/web/20130111132644/http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/meridia_hpc-cps-eng.php Archived] 2013-01-11 at the [[Wayback Machine]]: Subject: Voluntary withdrawal of Meridia (sibutramine) capsules from the Canadian market.</ref> Cina,<ref>[https://web.archive.org/web/20111007065924/http://www.sda.gov.cn/WS01/CL0195/55333.html "Notification of Termination of Production, Sale, and Usage of Sibutramine Preparations and Their Active Pharmaceutical Ingredient"]. sda.gov in People's Republic of China. October 30, 2010. Archived from [http://www.sda.gov.cn/WS01/CL0195/55333.html the original] on 2011-10-07. Retrieved 2011-05-21.</ref> Uni Eropa,<ref>(in German) Sibutramin-Vertrieb in der Europäischen Union ausgesetzt [http://www.abbott.de/content/e17/e127/e15940/index_de.html <nowiki>[1]</nowiki>] [https://archive.today/20120719155409/http://www.abbott.de/content/e17/e127/e15940/index_de.html Archived] 2012-07-19 at archive.today. [[Abbott Laboratories]] in Germany. Press Release 2010-01-21. Retrieved 2010-01-27</ref> Hong Kong,<ref>[http://www.info.gov.hk/gia/general/201011/02/P201011020204.htm "De-registration of pharmaceutical products containing sibutramine"] (Press release). info.gov in Hong Kong. November 2, 2010. Retrieved 2010-11-08.</ref> India,<ref>[http://pib.nic.in/newsite/erelease.aspx?relid=70841 "Banned Medicines"] (Press release). Ministry of Health and Family Welfare. February 10, 2011. Retrieved 2011-03-15.</ref> Selandia Baru,<ref>[http://www.medsafe.govt.nz/hot/media/2010/SibutramineOct2010.asp "Withdrawal of Sibutramine (Reductil) in New Zealand"] (Press release). MedSafe in New Zealand. October 11, 2010. Retrieved 2012-11-06.</ref> Filipina,<ref>[http://business.inquirer.net/159883/fda-warns-online-sellers-of-banned-slimming-pills "FDA warns online sellers of banned slimming pills"]. January 12, 2014. [https://web.archive.org/web/20140115102854/http://business.inquirer.net/159883/fda-warns-online-sellers-of-banned-slimming-pills Archived] from the original on January 15, 2014. Retrieved February 20, 2014.</ref> Thailand,<ref>[https://web.archive.org/web/20110511225841/http://elib.fda.moph.go.th/fulltext2/word/41633/41633.pdf "Thai FDA reveals voluntary withdrawal of sibutramine from the Thai market"] (Press release). Food and Drug Administration of Thailand. October 20, 2010. Archived from [http://elib.fda.moph.go.th/fulltext2/word/41633/41633.pdf the original] on 2011-05-11. Retrieved 2010-12-22.</ref> Inggris,<ref>{{Cite news|date=2010-01-22|title=Top obesity drug being suspended|url=http://news.bbc.co.uk/2/hi/health/8473555.stm|language=en-GB|access-date=2024-01-06}}</ref> dan Amerika Serikat<ref>Rockoff JD, Dooren JC (October 8, 2010). [https://web.archive.org/web/20101011004015/http://online.wsj.com/article/BT-CO-20101008-710904.html "Abbott Pulls Diet Drug Meridia Off US Shelves"]. ''The Wall Street Journal''. Archived from [https://online.wsj.com/article/BT-CO-20101008-710904.html the original] on 11 October 2010. Retrieved 8 October 2010.</ref>. Mulai tanggal 14 Oktober 2010, distribusi sibutramin di Indonesia telah dilarang oleh [[Badan Pengawas Obat dan Makanan|Badan Pengawas Obat dan Makanan (BPOM)]].<ref>{{Cite web|last=Media|first=Kompas Cyber|date=2010-10-18|title=Obat Diet Mengandung Sibutramin Dilarang|url=https://health.kompas.com/read/2010/10/18/08033012/~Obat%20&%20Vitamin|website=KOMPAS.com|language=id|access-date=2024-01-06}}</ref>
== Referensi ==
<references/>
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== Pranala luar ==
*[http://www.abbott.com/global/url/pressRelease/en_US/60.5:5/Press_Release_0908.htm Abbott Press Release on Meridia Withdrawal] {{Webarchive|url=https://web.archive.org/web/20110927063744/http://www.abbott.com/global/url/pressRelease/en_US/60.5:5/Press_Release_0908.htm |date=2011-09-27 }}
*[http://www.merck.com/mmpe/lexicomp/sibutramine.html Sibutramine drug information] from ''[[Merck Manual]]''. Includes dosage information and a comprehensive list of international brand names
*[https://www.fda.gov/Safety/Recalls/default.htm#table U.S. Food and Drug Administration (FDA) product safety website]
[[Kategori:Anorektik]]
[[Kategori:Senyawa 4-klorofenil]]
[[Kategori:Siklobutana]]
[[Kategori:Senyawa dimetilamino]]
[[Kategori:Obat yang dikembangkan oleh AbbVie]]
[[Kategori:Fenetilamina]]
[[Kategori:Bakal obat]]
[[Kategori:Penghambat pengambilan kembali serotonin–norepinefrin–dopamin]]
[[Kategori:Stimulan]]
[[Kategori:Amfetamina tersubstitusi]]
[[Kategori:Obat yang ditarik]]
[[Kategori:Bahan terlarang Badan Antidoping Dunia]]
[[Kategori:Senyawa isobutil]]
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