Etinodiol: Perbedaan antara revisi
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'''Etinodiol''' adalah progestin [[steroid]] dari kelompok 19-nortestosteron yang tidak pernah dipasarkan.<ref name="Macdonald1997">{{cite book | vauthors = Macdonald F | title = Dictionary of Pharmacological Agents | url = https://books.google.com/books?id=A0THacd46ZsC&pg=PA1454 | access-date = 12 May 2012 | year = 1997 | publisher = CRC Press | isbn = 978-0-412-46630-4 | page = 1454}}</ref><ref name="IndexNominum2000">{{cite book | title = Index Nominum 2000: International Drug Directory | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA422 | access-date = 30 May 2012 | year = 2000 | publisher = Taylor & Francis US | isbn = 978-3-88763-075-1 | page = 422}}</ref><ref name="SchindlerCampagnoli2003">{{cite journal | vauthors = Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH | title = Classification and pharmacology of progestins | journal = Maturitas | volume = 46 | pages = S7–S16 | date = December 2003 | issue = Suppl 1 | pmid = 14670641 | doi = 10.1016/j.maturitas.2003.09.014 }}</ref> Turunan
==Farmakologi==
Etinodiol adalah [[bakal obat]] dari [[noretisteron]], dan diubah segera dan sepenuhnya menjadi noretisteron.<ref name="ShoupeHaseltine2012">{{cite book| vauthors = Shoupe D, Haseltine FP |title=Contraception|url=https://books.google.com/books?id=cpDhBwAAQBAJ&pg=PA21|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-2730-4|pages=21–}}</ref><ref name="Bhattacharya2003">{{cite book|author=Bhattacharya|title=Pharmacology, 2/e|url=https://books.google.com/books?id=X3cCZQCrrjcC&pg=PA378|date=1 January 2003|publisher=Elsevier India|isbn=978-81-8147-009-6|pages=378–}}</ref><ref name="HumansOrganization2007">{{cite book|author1=IARC Working Group on the Evaluation of Carcinogenic Risks to Humans|author2=World Health Organization|author3=International Agency for Research on Cancer|title=Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy|url=https://books.google.com/books?id=aGDU5xibtNgC&pg=PA146|year=2007|publisher=World Health Organization|isbn=978-92-832-1291-1|pages=146–}}</ref> Etinodiol adalah zat antara dalam konversi obat pendahulu [[linestrenol]] menjadi noretisteron.<ref name="pmid2256526">{{cite journal | vauthors = Hammerstein J | title = Prodrugs: advantage or disadvantage? | journal = American Journal of Obstetrics and Gynecology | volume = 163 | issue = 6 Pt 2 | pages = 2198–203 | date = December 1990 | pmid = 2256526 | doi = 10.1016/0002-9378(90)90561-K }}</ref>
==Kimia==
Etinodiol merupakan turunan 19-nortestosteron. Secara struktural, ia hampir identik dengan noretisteron dan linestrenol, hanya berbeda pada substituen C3-nya. Sementara noretisteron memiliki [[keton]] pada C3 dan linestrenol tidak memiliki substituen pada C3, etinodiol memiliki gugus [[hidroksil]] pada posisi tersebut.
===Sintesis===
[[File:Ethynodiol diacetate synthesis.svg|thumb|left|700px|Sintesis etynodiol diasetat:<ref>{{cite journal | vauthors = Klimstra PD, Colton FB | title = The synthesis of 3beta-hydroxyestr-4-en-17-one and 3beta-hydroxyandrost-4-en-17-one | journal = Steroids | volume = 10 | issue = 4 | pages = 411–24 | date = October 1967 | pmid = 6064262 | doi = 10.1016/0039-128X(67)90119-5 }}</ref> F. B. Colton, {{US patent|2843609}} (1958 kepada G.D. Searle, LLC). Preparasi 3-asetat, 17-asetat, dan diasetat: P. D. Klimstra, {{US patent|3176013}} (1965 kepada G.D. Searle, LLC); lihat juga:<ref>{{Cite journal | doi = 10.1016/0040-4020(59)80066-1| title = Synthesis of 3β-hydroxy analogues of steroidal hormones, a biologically active class of compounds| journal = Tetrahedron| volume = 5| pages = 15–26| year = 1959| vauthors = Sondheimer F, Klibansky Y }}</ref>]]{{Clear}}
==Masyarakat dan budaya==
===Nama generik===
''Etynodiol'' adalah nama generiknya menurut [[Nama Generik Internasional|INN]], sedangkan ''ethynodiol'' adalah Nama yang Disetujui Britania Raya (BAN).<ref name="Macdonald1997" /><ref name="IndexNominum2000" />
==Referensi==
{{Reflist}}
[[Kategori:Senyawa etunil]]
[[Kategori:Steroid anabolik–androgenik]]
[[Kategori:Diol]]
[[Kategori:Estrana]]
[[Kategori:Bakal obat]]
[[Kategori:Progestogen]]
[[Kategori:Estrogen sintetik]]
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