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Efek sampingnya adalah pusing, gangguan perkembangan janin, gangguan fungsi hati, bengkak, dan meningkatkan enzim transaminase hati.<ref name=":0" /><ref>{{Cite journal|last=Galiè|first=Nazzareno|last2=Humbert|first2=Marc|last3=Vachiery|first3=Jean-Luc|last4=Gibbs|first4=Simon|last5=Lang|first5=Irene|last6=Torbicki|first6=Adam|last7=Simonneau|first7=Gérald|last8=Peacock|first8=Andrew|last9=Vonk Noordegraaf|first9=Anton|date=2016-01-01|title=2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertensionThe Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)|url=https://academic.oup.com/eurheartj/article/37/1/67/2887599|journal=European Heart Journal|language=en|volume=37|issue=1|pages=67–119|doi=10.1093/eurheartj/ehv317|issn=0195-668X}}</ref><ref>{{Cite web|url=https://www.drugs.com/cdi/bosentan-tablets.html|title=Bosentan Tablets: Indications, Side Effects, Warnings|website=Drugs.com|language=en|access-date=2020-03-09}}</ref>
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