Ribosomal s6 kinase: Perbedaan antara revisi
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'''Kinase ribosomal s6''' ({{lang-en|ribosomal s6 kinase, A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; protein kinase (phosphorylating); protein kinase A; protein kinase CK2; protein kinase p58; protein phosphokinase; protein serine kinase; protein serine-threonine kinase; Serine/threonine-protein kinase B-raf, proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, protein-aspartyl kinase; protein-cysteine kinase; protein-serine kinase; Prp4 protein kinase; Raf kinase; Raf-1; ribosomal protein S6 kinase II; ribosomal S6 protein kinase; serine kinase; serine protein kinase; serine-specific protein kinase; serine(threonine) protein kinase; serine/threonine protein kinase; STK32; T-antigen kinase; threonine-specific protein kinase; twitchin kinase; type-2 casein kinase; βIIPKC; ε PKC; Wee 1-like kinase; Wee-kinase; WEE1Hu, Rsk, EC 2.7.11.1}})<ref>{{en}} {{cite web|url=http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/7/11/1.html|title=EC 2.7.11.1|accessdate=2011-07-09|work=Queen Mary University of London}}</ref> adalah [[kinase protein]] yang mempercepat reaksi [[fosforilasi]] pada residu [[serina]]/[[treonina]] dan teraktivasi melalui [[lintasan metabolisme|lintasan]] [[Kinase MAP|MAPK]]/ERK. Terdapat dua jenis Rsk, p90<sup>rsk</sup> atau ''MAPK-activated protein kinase-1'' (MAPKAP-K1) dan p70<sup>rsk</sup> atau S6-H1 Kinase atau S6K. [[Manusia]] memiliki 4 [[ekspresi genetik|ekspresi]] Rsk,<ref name="AACR67178104">{{en}} {{cite web
| url = http://cancerres.aacrjournals.org/content/67/17/8104.full
| title = Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter–Induced Cell Transformation
| accessdate = 2011-07-09
| work = Hormel Institute, University of Minnesota; Yong-Yeon Cho, Ke Yao, Hong-Gyum Kim, Bong Seok Kang, Duo Zheng, Ann M. Bode, dan Zigang Dong
}}</ref> yaitu RSK-1, RSK-2, RSK-3, RSK-4.
| url = http://www.uniprot.org/uniprot/P15056
| title = P15056 (BRAF_HUMAN) Reviewed
| accessdate = 2011-07-13
| work = UniProt
}}</ref> Pada [[sistem saraf]], Rsk diketahui mempercepat fosforilasi pada [[protein]] pro-[[apoptosis|apoptotik]] [[BAD]] pada [[serina]] residu 112, baik ''in vitro'' maupun ''in vivo''.<ref>{{en}} {{cite web
| url = Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
| title = Humoral Immunity
| accessdate = 2011-07-09
| work = Division of Neuroscience, Children's Hospital, and Department of Neurobiology, Harvard Medical School; Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME.
}}</ref> Fosforilasi ini mencegah apoptosis [[neuron]] yang dimediasi oleh BAD. [[Katalis
RSK-2, ketika teraktivasi, akan bermigrasi menuju ke dalam [[inti sel]] dan menkatalis berbagai protein inti seperti [[c-Fos]], [[Elk-1]], [[histon]], CREB, [[ATF-4]] dan [[p53]].<ref name="AACR67178104" /> Pada [[hewan]] [[tikus]], terhambatnya RSK-2 meredakan terbentuknya [[osteosarkoma]] yang bergantung pada c-Fos. Sedangkan senyawa [[SL-0101]] yang merupakan ekstrak tumbuhan tropis [[Forsteronia refracta]] dapat menghambat aktivitas RSK-2 dan menekan [[proliferasi]] [[sel (biologi)|sel]] [[kanker payudara]] [[sel MCF-7|MCF-7]] dan sel [[kanker prostat]] [[sel LNCap|LNCaP]]. [[Mutasi]] [[gen]]etik RSK-2 akan menyebabkan penyimpangan pada [[lintasan metabolisme|lintasan]] [[Kinase MAP|MAPK]]/Rsk hingga menginduksi [[sindrom Coffin-Lowry]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/8955270
| title = Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome.
| accessdate = 2011-07-09
| work = Institut de Génétique et de Biologie Moléculaire et Cellulaire; Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A.
}}</ref>
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