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Antiperadangan nonsteroid: Perbedaan antara revisi

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Baris 1:
{{Infobox drug class
|Name = Antiperadangan nonsteroid
|Image = 200mg ibuprofen tablets.jpg
|Alt =
|Caption = Tablet salut selaput 200 mg [[ibuprofen]] generik, obat antiinflamasi nonsteroid yang umum
|Pronounce= {{IPAc-en|ˈ|ɛ|n|s|ɛ|d}} {{respell|EN|sed}}
|Synonyms = {{plainlist}}
* Penghambat siklooksigenase<ref name="stat">{{Citation |last1=Ghlichloo |first1=Ida |title=Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) |date=1 May 2023 |work=StatPearls |url=http://www.ncbi.nlm.nih.gov/books/NBK547742/ |access-date=2024-03-31 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31613522 |last2=Gerriets |first2=Valerie |archive-date=23 April 2024 |archive-url=https://web.archive.org/web/20240423114005/https://ncbi.nlm.nih.gov/books/NBK547742/ |url-status=live }}</ref>
* Penghambat enzim siklooksigenase<ref name=stat/>
* Agen antiinflamasi nonsteroid/analgesik
{{endplainlist}}
<!-- Class identifiers -->
|Use = [[Analgesik]],<ref name=OED/> [[antipiretik]],<ref name=OED/> [[antiinflamasi]],<ref name=OED/> [[antitrombotik]]{{Citation needed|date=February 2022}}
|ATC_prefix = M01A
|Mode_of_action =
|Biological_target = [[COX-1]] and [[COX-2]]
|Mechanism_of_action= [[Inhibitor enzim]]
|Chemical_class =
<!-- Clinical data -->
|Drugs.com = <!-- {{Drugs.com|drug-class|?}} -->
|Consumer_Reports=
|medicinenet =
|rxlist =
<!-- External links -->
|MeshID =
}}
 
'''Obat anti-inflamasiAntiperadangan nonsteroid''', (OAINSBahasa (atauInggris: '''''Nonsteroidal anti-inflammatory drugs''''', (disingkat '''NSAIDs''') atau '''obat antiinflamasi nonsteroid'''<ref name=OED>{{Cite web|title=non-steroidal anti-inflammatory drug|url=https://www.lexico.com/definition/non-steroidal_anti-inflammatory_drug|website=www.Lexico.com|publisher=[[Oxford English Dictionary]]|date=2022|access-date=4 February 2022|archive-date=5 February 2022|archive-url=https://web.archive.org/web/20220205104155/https://www.lexico.com/definition/non-steroidal_anti-inflammatory_drug|url-status=dead}}</ref> (disingkat '''OAINS''') adalah kelas obat yang sama-sama memberikan efek analgesik (antinyeri) dan antipiretik (penurun panas), dandalamdan dalam dosis yang lebih tinggi berefek efek anti-inflamasi. Istilah "nonsteroid" membedakan obat ini dari atinanti-inflamasi lain yaitu "[[steroid]]", yang bekerja menekan produksi [[eikosanoid]]. Istilah ini pertama kali digunakan pada tahun 1960, digunakan untuk menjauhkan obat baru dari tragedi [[iatrogenik]] terkait steroid.<ref name="Buer_2014">{{cite journal | vauthors = Buer JK | title = Origins and impact of the term 'NSAID' | journal = Inflammopharmacology | volume = 22 | issue = 5 | pages = 263–7 | date = Oct 2014 | url = https://www.researchgate.net/publication/264248818_Origins_and_impact_of_the_term_'NSAID' | pmid = 25064056 | doi = 10.1007/s10787-014-0211-2 }}</ref>
 
== Klasifikasi ==
OAINS dapat diklasifikasikan berdasarkan struktur kimianya atau mekanisme aksi. OAINS lebih tua dikenal jauh sebelum mekanisme aksi mereka itu dijelaskan dan untuk alasan ini diklasifikasikan oleh struktur atau asal kimia. Zat baru lebih sering diklasifikasikan berdasarkan mekanisme aksi.
 
Baris 40 ⟶ 66:
* [[Diklofenak]]
* [[Aseklofenak]]
* [[Nabumeton]]
 
{{colend}}
Baris 67 ⟶ 93:
{{colend}}
 
=== SelectivePenghambat COXsiklooksigenase-2 inhibitorsselektif ([[Coxibskoksib]]) ===
{{colbegin||25em}}
 
* [[CelecoxibSelekoksib]] (FDAPerhatian alertFDA<ref>Information for Healthcare Professionals: Celecoxib (marketed as Celebrex) http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124655.htm</ref>)
* [[RofecoxibRofekoksib]] (withdrawnditarik fromdari marketpasar<ref name="urlFDA Public Health Advisory: Safety of Vioxx">{{cite web | url = http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm106274.htm | title = Safety of Vioxx | work = FDA Public Health Advisory | publisher = United States Food and Drug Administration }}</ref>)
* [[ValdecoxibValdekoksib]] (withdrawnditarik fromdari marketpasar<ref>[http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124649.htm Alert for Healthcare Professionals: Valdecoxib (marketed as Bextra)]</ref>)
* [[ParecoxibParekoksib]] ditarik FDA withdrawn, licensed inberlisensi thedi EU
* [[Lumirakoksib]] pendaftaran dibatalkan TGA (Australia)
* [[Lumiracoxib]] TGA cancelled registration
* [[EtoricoxibEtorikoksib]] nottidak disetujui FDA approved, licensed inberlisensi thedi EU
* [[Firocoxib]] useddigunakan inpada dogsanjing anddan horseskuda
 
{{colend}}
 
=== SulfonanilidesSulfonanilid ===
 
* [[Nimesulid]] (sediaan sistemik dilarang oleh beberapa negara karena potensi risiko hepatotoksisitas)
* [[Nimesulide]] (systemic preparations are banned by several countries for the potential risk of hepatotoxicity)
 
=== OthersLainnya ===
 
* [[ClonixinKloniksin]]
* [[LicofeloneLikofelon]] actsberaksi bydengan inhibitingmenghambat LOX (lipooxygenaselipooksigenase) & COX anddan hencekarenanya knowndikenal assebagai 5-LOX/COX inhibitor
* H-harpagide indalam ''[[Scrophularia|Figwort]]''<ref name="pmid22414102">{{cite journal |vauthors=Viljoen A, Mncwangi N, Vermaak I | title = Anti-inflammatory iridoids of botanical origin | journal = Curr. Med. Chem. | volume = 19 | issue = 14 | pages = 2104–27 | year = 2012 | pmid = 22414102 | pmc = 3873812 | doi = 10.2174/092986712800229005 }}</ref> oratau ''[[Harpagophytum|Devil's Claw]]''<ref name="pmid21775152">{{cite journal |vauthors=Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y | title = Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro | journal = Bioorg. Med. Chem. | volume = 19 | issue = 16 | pages = 4882–6 | year = 2011 | pmid = 21775152 | doi = 10.1016/j.bmc.2011.06.069 }}</ref>
 
{{colend}}
 
== Referensi ==
 
{{reflist}}
[[Kategori: Obat anti-inflamasi nonsteroid]]
{{Obat antiinflamasi nonsteroid}}
[[Kategori:Antiperadangan nonsteroid| ]]
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