Sibutramina: Perbedaan antara revisi
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[[Berkas:Sibutramine.svg|jmpl|Struktur kimia sibutramin]]
'''Sibutramin''' merupakan [[obat]] penekan [[nafsu makan]] yang dijual dengan merek dagang '''Meridia''' atau '''Reductil'''. Hingga tahun 2010, sibutramin dipasarkan secara luas dan diresepkan sebagai obat dalam pengobatan [[Kegemukan|obesitas]].<ref>{{Cite journal|date=2008|title=Sibutramine (Meridia)|url=http://dx.doi.org/10.4135/9781412963862.n421|journal=Encyclopedia of Obesity|location=2455 Teller Road, Thousand Oaks California 91320 United States|publisher=SAGE Publications, Inc.}}</ref> Mekanisme utama obat ini adalah penghambatan pengambilan kembali [[serotonin]] dan [[Noradrenalin|norepinefrin]] pada [[sinapsis]] [[Sel saraf|neuron]] yang menghasilkan efek penurunan asupan energi dan meningkatkan rasa kenyang.<ref>{{Cite journal|last=Lean|first=M. E. J.|date=2001-12|title=How does sibutramine work?|url=https://www.nature.com/articles/0801931|journal=International Journal of Obesity|language=en|volume=25|issue=4|pages=S8–S11|doi=10.1038/sj.ijo.0801931|issn=1476-5497}}</ref>
Di banyak negara, penjualan sibutramin telah dihentikan pada tahun 2010 karena penggunaannya dikaitkan dengan peningkatan kasus [[penyakit kardiovaskular]] dan [[strok]]. Beberapa negara yang menarik sibutramin dari pasar di antaranya adalah Australia,<ref>{{Cite journal|last=&NA;|date=2010-06|title=The Australian Therapeutic Goods Administration (TGA) is reviewing the safety of sibutramine|url=http://dx.doi.org/10.2165/00128415-201013040-00014|journal=Reactions Weekly|volume=&NA;|issue=1304|pages=5|doi=10.2165/00128415-201013040-00014|issn=0114-9954}}</ref> Kanada,<ref>[https://hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/meridia_hpc-cps-eng.php Health Canada Endorsed Important Safety Information on MERIDIA (Sibutramine Hydrochloride Monohydrate)] [https://web.archive.org/web/20130111132644/http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/meridia_hpc-cps-eng.php Archived] 2013-01-11 at the [[Wayback Machine]]: Subject: Voluntary withdrawal of Meridia (sibutramine) capsules from the Canadian market.</ref> Cina,<ref>[https://web.archive.org/web/20111007065924/http://www.sda.gov.cn/WS01/CL0195/55333.html "Notification of Termination of Production, Sale, and Usage of Sibutramine Preparations and Their Active Pharmaceutical Ingredient"]. sda.gov in People's Republic of China. October 30, 2010. Archived from [http://www.sda.gov.cn/WS01/CL0195/55333.html the original] on 2011-10-07. Retrieved 2011-05-21.</ref> Uni Eropa,<ref>(in German) Sibutramin-Vertrieb in der Europäischen Union ausgesetzt [http://www.abbott.de/content/e17/e127/e15940/index_de.html <nowiki>[1]</nowiki>] [https://archive.today/20120719155409/http://www.abbott.de/content/e17/e127/e15940/index_de.html Archived] 2012-07-19 at archive.today. [[Abbott Laboratories]] in Germany. Press Release 2010-01-21. Retrieved 2010-01-27</ref> Hong Kong,<ref>[http://www.info.gov.hk/gia/general/201011/02/P201011020204.htm "De-registration of pharmaceutical products containing sibutramine"] (Press release). info.gov in Hong Kong. November 2, 2010. Retrieved 2010-11-08.</ref> India,<ref>[http://pib.nic.in/newsite/erelease.aspx?relid=70841 "Banned Medicines"] (Press release). Ministry of Health and Family Welfare. February 10, 2011. Retrieved 2011-03-15.</ref> Selandia Baru,<ref>[http://www.medsafe.govt.nz/hot/media/2010/SibutramineOct2010.asp "Withdrawal of Sibutramine (Reductil) in New Zealand"] (Press release). MedSafe in New Zealand. October 11, 2010. Retrieved 2012-11-06.</ref> Filipina,<ref>[http://business.inquirer.net/159883/fda-warns-online-sellers-of-banned-slimming-pills "FDA warns online sellers of banned slimming pills"]. January 12, 2014. [https://web.archive.org/web/20140115102854/http://business.inquirer.net/159883/fda-warns-online-sellers-of-banned-slimming-pills Archived] from the original on January 15, 2014. Retrieved February 20, 2014.</ref> Thailand,<ref>[https://web.archive.org/web/20110511225841/http://elib.fda.moph.go.th/fulltext2/word/41633/41633.pdf "Thai FDA reveals voluntary withdrawal of sibutramine from the Thai market"] (Press release). Food and Drug Administration of Thailand. October 20, 2010. Archived from [http://elib.fda.moph.go.th/fulltext2/word/41633/41633.pdf the original] on 2011-05-11. Retrieved 2010-12-22.</ref> Inggris,<ref>{{Cite news|date=2010-01-22|title=Top obesity drug being suspended|url=http://news.bbc.co.uk/2/hi/health/8473555.stm|language=en-GB|access-date=2024-01-06}}</ref> dan Amerika Serikat<ref>Rockoff JD, Dooren JC (October 8, 2010). [https://web.archive.org/web/20101011004015/http://online.wsj.com/article/BT-CO-20101008-710904.html "Abbott Pulls Diet Drug Meridia Off US Shelves"]. ''The Wall Street Journal''. Archived from [https://online.wsj.com/article/BT-CO-20101008-710904.html the original] on 11 October 2010. Retrieved 8 October 2010.</ref>. Mulai tanggal 14 Oktober 2010, distribusi sibutramin di Indonesia telah dilarang oleh [[Badan Pengawas Obat dan Makanan|Badan Pengawas Obat dan Makanan (BPOM)]].<ref>{{Cite web|last=Media|first=Kompas Cyber|date=2010-10-18|title=Obat Diet Mengandung Sibutramin Dilarang|url=https://health.kompas.com/read/2010/10/18/08033012/~Obat%20&%20Vitamin|website=KOMPAS.com|language=id|access-date=2024-01-06}}</ref>
== Catatan kaki ==
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{{farmasi-stub}}
[[Kategori:Obat yang ditarik]]
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