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'''ETS''' ({{lang-en|E26 transformation-specific}}) adalah sekelompok [[faktor transkripsi]] yang mengatur [[diferensiasi]], respon terhadap [[hormon]] dan [[lintasan metabolisme|lintasan]] [[tumorigenesis]] pada sejumlah [[organ]] [[endokrin]] dan [[jaringan]] [[tubuh]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/17387021
| title = ETS transcription factors in endocrine systems.
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Ets-1, salah satu anggota ETS, merupakan [[protein]] yang langsung mengatur banyak [[gen]] penting pada lintasan [[angiogenesis]] dan ''extracellular matrix remodeling'', seperti [[metaloproteinase matriks-1|MMP-1]], [[metaloproteinase matriks-3|MMP-3]], [[metaloproteinase matriks-9|MMP-9]], [[aktivator urokinase plasminogen|uPA]], dan [[integrin|integrin-β3]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962648
| title = Ets-1 Regulates Energy Metabolism in Cancer Cells
| accessdate = 2011-07-23
| work = Department of Research, Juravinski Cancer Centre, Department of Medical Science, Department of Pathology and Molecular Medicine,McMaster University, Duke University; Meghan L. Verschoor, Leigh A. Wilson, Chris P. Verschoor, dan Gurmit Singh
}}</ref> [[Kinase MAP|MAPK]] merupakan [[enzim]] akan mengaktivasi Ets-1 dan Ets-2.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/15572696
| title = Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.