Somers menderita [[Hiperplasi|hiperplasiahiperplasi]]a pada usia 20-an dan [[kanker kulit]] pada usia 30-an.<ref name=guardianobit>{{Cite news | url=https://www.theguardian.com/tv-and-radio/2023/oct/15/suzanne-somers-actor-threes-company-american-graffiti | title=Suzanne Somers, star of Three's Company sitcom, dies aged 76 | first=Edward | last=Helmore | work=[[The Guardian]] | date=October 15, 2023}}</ref> Pada bulan April 2000, Somers didiagnosis menderita [[kanker payudara]] dan menjalani [[lumpektomi]] untuk mengangkat kanker, diikuti dengan [[Radioterapi|terapi radiasi]].<ref name=timeline>{{cite news |url=https://people.com/suzanne-somers-cancer-battle-timeline-8358254 |title=A Timeline of Suzanne Somers' Struggle with Cancer |first1=Bailey |last1=Richards |first2=Alexis |last2=Jones |work=People}}</ref> Pada tahun 2018, dilaporkan bahwa dia menjalani terapi sel induk eksperimental untuk menumbuhkan kembali payudaranya yang hilang karena kanker.<ref>{{Cite web |last=Meola |first=Kiki |date=2018-10-09 |title=Suzanne Somers Update on Experimental Post-Cancer Regrown Breast |url=https://www.usmagazine.com/celebrity-body/news/suzanne-somers-update-on-experimental-post-cancer-regrown-breast/ |access-date=2023-10-17 |website=Us Weekly |language=en-US}}</ref>
Pada tahun 2020, Somers mengalami patah pinggul saat dia melompat keluar dari trem pribadi menuju rumahnya.<ref>{{cite news |url=https://www.foxnews.com/entertainment/suzanne-somers-73-staying-in-shape |title=Suzanne Somers, 73, says she's passionate about staying in shape: 'Find a movement protocol that turns you on' | first=Stephanie | last=Nolasco | work=[[Fox News]] |date=June 23, 2020}}</ref>
