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Baris 9: <!-- Pharmacokinetic data -->\|bioavailability=\|protein_bound=\|metabolism=\|elimination_half-life=3-8 hours\|excretion=<!-- Chemical and physical data -->\|C=30\|H=53\|N=1\|O=11\|chemical_formula=\|smiles=O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)c1ccc(NCCCC)cc1\|StdInChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3\|StdInChI_Ref={{stdinchicite\|correct\|chemspider}}\|StdInChI_comment=\|StdInChIKey=MAFMQEKGGFWBAB-UHFFFAOYSA-N\|StdInChIKey_Ref={{stdinchicite\|correct\|chemspider}}\|density=\|melting_point=\|melting_high=\|melting_notes=\|boiling_point=\|boiling_notes=\|solubility=\|specific_rotation=}} '''Benzonatat''' atau Benzonatate adalah [[obat]] yang digunakan untuk membantu menurunkan gejala dari [[batuk]] dan [[cegukan]] . <ref name="AHFS2019">{{Cite web\|title=Benzonatate Monograph for Professionals\|url=https://www.drugs.com/monograph/benzonatate.html\|website=Drugs.com\|publisher=American Society of Health-System Pharmacists\|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html\|archive-date=28 December 2021\|access-date=23 March 2019\|url-status=live}}</ref> <ref name="Bec2010">{{Cite journal\|last=Becker\|first=DE\|date=2010\|title=Nausea, vomiting, and hiccups: a review of mechanisms and treatment.\|journal=Anesthesia Progress\|volume=57\|issue=4\|pages=150–6; quiz 157\|doi=10.2344/0003-3006-57.4.150\|pmc=3006663\|pmid=21174569}}</ref> Rute pemberian obat melalui oral. <ref name="AHFS2019"~~>{{cite~~ ~~web \|title=Benzonatate Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/benzonatate.html \|website=Drugs.com \|publisher=American Society of Health-System Pharmacists \|accessdate=23 March 2019 \|archive-date=28 December 2021 \|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html \|url-status=live }}</ref> Penggunaan obat tidak direkomendasikan anak yang berusia di bawah 10 tahun. <ref name="ML2018">{{Cite journal\|date=17 December 2018\|title=Drugs for cough.\|journal=The Medical Letter on Drugs and Therapeutics\|volume=60\|issue=1562\|pages=206–208\|pmid=30625123}}</ref> Efek terapi muncul memerlukan waktu kurang lebih 20 menit dan akan bertahan hingga 8 jam. <ref name="AHFS2019"~~>{{cite~~ ~~web \|title=Benzonatate Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/benzonatate.html \|website=Drugs.com \|publisher=American Society of Health-System Pharmacists \|accessdate=23 March 2019 \|archive-date=28 December 2021 \|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html \|url-status=live }}</ref> <ref name="PI2021">{{Cite web\|last=\|first=\|date=20 November 2019\|title=Tessalon - benzonatate capsule\|url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8edd07a0-5f5b-9000-bafb-dbf8ff7609d4\|website=DailyMed\|archive-url=https://web.archive.org/web/20211107100900/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8edd07a0-5f5b-9000-bafb-dbf8ff7609d4\|archive-date=7 November 2021\|access-date=21 April 2020\|url-status=live}}</ref> Kejadian efek samping yang umum terjadi pada penggunaan obat ini yakni rasa mengantuk, ras pusing, sakit kepala, sakit perut, ruam kulit, [[halusinasi]], dan [[Alergi\|timbul reaksi alergi]] . <ref name="AHFS2019"~~>{{Cite~~ ~~web\|title=Benzonatate Monograph for Professionals\|url=https:~~//www.drugs.com/monograph/benzonatate.html\|website=Drugs.com\|publisher=American Society of Health-System Pharmacists\|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html\|archive-date=28 December 2021\|access-date=23 March 2019\|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/benzonatate.html "Benzonatate Monograph for Professionals"]. ''Drugs.com''. American Society of Health-System Pharmacists. [https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html Archived] from the original on 28 December 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">23 March</span> 2019</span>.</cite></ref> Penggunaan dosis yang berlebih bisa menyebabkan [[Sawan\|kejang]], [[Aritmia\|detak jantung tidak teratur]], hingga kematian. <ref name="ML2018"~~>{{Cite~~ journal\|date=17 December 2018\|title=Drugs for cough.\|journal=The Medical Letter on Drugs and Therapeutics\|volume=60\|issue=1562\|pages=206–208\|pmid=30625123}}<cite class="citation journal cs1" data-ve-ignore="true">"Drugs for cough". ''The Medical Letter on Drugs and Therapeutics''. '''60''' (1562): 206–208. 17 December 2018. [[PubMed\|PMID]] [https:/~~/pubmed.ncbi.nlm.nih.gov/30625123 30625123].</cite></ref~~> Jika menghisap ataupun mengunyah sediaan kapsul obat ini bisa menyebabkan [[laringospasme]], bronkospasme, dan [[syok]] . <ref name="AHFS2019"~~>{{cite~~ ~~web \|title=Benzonatate Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/benzonatate.html \|website=Drugs.com \|publisher=American Society of Health-System Pharmacists \|accessdate=23 March 2019 \|archive-date=28 December 2021 \|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html \|url-status=live }}</ref> Belum diketahui secara pasti apakah obat ini aman untuk ibu [[Kehamilan\|hamil]] atau ibu[[menyusui]] . <ref name="Preg2020">{{Cite web\|date=10 October 2019\|title=Benzonatate Use During Pregnancy\|url=https://www.drugs.com/pregnancy/benzonatate.html\|website=Drugs.com\|archive-url=https://web.archive.org/web/20211108073032/https://www.drugs.com/pregnancy/benzonatate.html\|archive-date=8 November 2021\|access-date=20 February 2020\|url-status=live}}</ref> Mekanisme kerja obat ini yakni dengan menghentikan reseptor regangan di paru-paru dan menekan refleks batuk di otak. <ref name="AHFS2019"~~>{{cite~~ ~~web \|title=Benzonatate Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/benzonatate.html \|website=Drugs.com \|publisher=American Society of Health-System Pharmacists \|accessdate=23 March 2019 \|archive-date=28 December 2021 \|archive-url=https://web.archive.org/web/20211228052158/https://www.drugs.com/monograph/benzonatate.html \|url-status=live }}</ref> == Referensi == [[Kategori:~~Obat~~Antitusif]] [[Kategori:~~Farmasi~~Anestesi lokal]] [[Kategori:Ester 4-aminobenzoat]] [[Kategori:Eter glikol]] [[Kategori:Amina sekunder]] [[Kategori:Senyawa metoksi]] [[Kategori:Penghalang saluran natrium]] <references />{{Farmasi-stub}}