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Revisi per 10 Februari 2024 13.50 sunting WanaraLima (bicara \| kontrib) 1.731 suntingan Artikel baru tentang topik farmasi yang masih memerlukan tambahan dan pengembangan. Artikel ini merupakan terjemahan wikipedia bahasa Inggris masih perlu ditinjau ulang juga disesuaikan dengan padanan bahasa Indonesia Tag: halaman dengan galat kutipan VisualEditor ← Revisi sebelumnya		Revisi terkini sejak 26 November 2024 12.35 sunting balikkan Muhammad Anas Sidik (bicara \| kontrib) 26.884 suntingan Tidak ada ringkasan suntingan Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan
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Baris 1: {{Infobox drug\|drug_name=\|image=Venlafaxine structure.svg\|alt=\|image2=Venlafaxine-3D-balls.png\|caption=<!-- \| type = mab / vaccine / combo -->\|type=<!-- Names -->\|tradename=Effexor, Efexor, others<ref name=brands />\|synonyms=\|IUPAC_name=(''RS'')-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexanol <!-- Clinical data -->\|pregnancy_AU=B2\|pregnancy_US=C\|pregnancy_category=\|routes_of_administration=By mouth\|Drugs.com={{drugs.com\|monograph\|Venlafaxine_Hydrochloride}}\|MedlinePlus=<!-- Legal data -->\|legal_AU=S4\|legal_CA=Rx-only\|legal_UK=POM\|legal_US=Rx-only\|legal_status=\|DailyMedID=Venlafaxine\|licence_US=\|licence_EU=<!-- Pharmacokinetic data -->\|bioavailability=42±15%<ref name=TGA>{{cite web \|title=Apo-Venlafaxine XR Capsules \|work=TGA eBusiness Services \|publisher=Apotex Pty Ltd \|place=Macquarie Park, NSW \|date=13 April 2012 \|accessdate=6 November 2013 \|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|format=PDF \|archive-date=19 April 2018 \|archive-url=https://web.archive.org/web/20180419100649/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|url-status=live }}</ref>\|protein_bound=27±2% (parent compound), 30±12% (active metabolite, [[desvenlafaxine]])<ref name=DM>{{cite web \|title=Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited] \|work=DailyMed \|publisher=Aurobindo Pharma Limited \|date=February 2013 \|accessdate=6 November 2013 \|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|archive-date=30 January 2020 \|archive-url=https://web.archive.org/web/20200130180552/https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|url-status=live }}</ref>\|metabolism=Extensively metabolised by the [[liver]]<ref name=TGA~~>{{cite~~ ~~web \|title=Apo-Venlafaxine XR Capsules \|work=TGA eBusiness Services \|publisher=Apotex Pty Ltd \|place=Macquarie Park, NSW \|date=13 April 2012 \|accessdate=6 November 2013 \|url=https:~~//www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|format=PDF \|archive-date=19 April 2018 \|archive-url=https://web.archive.org/web/20180419100649/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|url-status=live }}</ref><ref name=DM~~>{{cite~~ ~~web \|title=Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited] \|work=DailyMed \|publisher=Aurobindo Pharma Limited \|date=February 2013 \|accessdate=6 November 2013 \|url=http:~~//dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|archive-date=30 January 2020 \|archive-url=https://web.archive.org/web/20200130180552/https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|url-status=live }}</ref>\|elimination_half-life=5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended release preparations), 11±2 h (active metabolite)<ref name=TGA~~>{{cite~~ ~~web \|title=Apo-Venlafaxine XR Capsules \|work=TGA eBusiness Services \|publisher=Apotex Pty Ltd \|place=Macquarie Park, NSW \|date=13 April 2012 \|accessdate=6 November 2013 \|url=https:~~//www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|format=PDF \|archive-date=19 April 2018 \|archive-url=https://web.archive.org/web/20180419100649/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|url-status=live }}</ref><ref name=DM~~>{{cite~~ ~~web \|title=Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited] \|work=DailyMed \|publisher=Aurobindo Pharma Limited \|date=February 2013 \|accessdate=6 November 2013 \|url=http:~~//dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|archive-date=30 January 2020 \|archive-url=https://web.archive.org/web/20200130180552/https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|url-status=live }}</ref>\|excretion=[[Kidney]] (87%; 5% as unchanged drug; 29% as [[desvenlafaxine]] and 53% as other metabolites)<ref name=TGA~~>{{cite~~ ~~web \|title=Apo-Venlafaxine XR Capsules \|work=TGA eBusiness Services \|publisher=Apotex Pty Ltd \|place=Macquarie Park, NSW \|date=13 April 2012 \|accessdate=6 November 2013 \|url=https:~~//www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|format=PDF \|archive-date=19 April 2018 \|archive-url=https://web.archive.org/web/20180419100649/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-01095-3 \|url-status=live }}</ref><ref name=DM~~>{{cite~~ ~~web \|title=Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited] \|work=DailyMed \|publisher=Aurobindo Pharma Limited \|date=February 2013 \|accessdate=6 November 2013 \|url=http:~~//dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|archive-date=30 January 2020 \|archive-url=https://web.archive.org/web/20200130180552/https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2 \|url-status=live }}</ref> <!-- Chemical and physical data -->\|C=17\|H=27\|N=1\|O=2\|smiles=OC2(C(c1ccc(OC)cc1)CN(C)C)CCCCC2\|StdInChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3\|StdInChI_Ref={{stdinchicite\|correct\|chemspider}}\|StdInChIKey=PNVNVHUZROJLTJ-UHFFFAOYSA-N\|StdInChIKey_Ref={{stdinchicite\|correct\|chemspider}}}} '''~~Venlafaxine~~Venlafaksin''' adalah obat [[antidepresan]] golongan dari serotonin-norepinefrin reuptake inhibitor (SNRI). <ref name="AHFS2018">{{Cite web\|title=Venlafaxine Hydrochloride Monograph for Professionals\|url=https://www.drugs.com/monograph/venlafaxine-hydrochloride.html\|website=Drugs.com\|publisher=AHFS\|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html\|archive-date=27 November 2020\|access-date=24 December 2018\|url-status=live}}</ref> Obat ini digunakan untuk mengatasi [[gangguan depresi mayor]] (MDD), [[Gangguan kecemasan menyeluruh\|gangguan kecemasan umum]] (GAD), gangguan panik, dan [[Gangguan kecemasan sosial\|fobia sosial]] . <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Venlafaxine Hydrochloride Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html \|website=Drugs.com \|publisher=AHFS \|accessdate=24 December 2018 \|archive-date=27 November 2020 \|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html \|url-status=live }}</ref> Obat iini juga bisa diperuntukkan untuk mengatasi [[Sakit kronis\|nyeri kronis]] . <ref>{{Cite web\|title=Antidepressants: Another weapon against chronic pain\|url=https://www.mayoclinic.org/pain-medications/art-20045647\|website=Mayo Clinic\|language=en\|archive-url=https://web.archive.org/web/20211026225927/https://www.mayoclinic.org/pain-medications/art-20045647\|archive-date=26 October 2021\|access-date=25 January 2020\|url-status=live}}</ref> Rute pemberian obat diberikan secara oral. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Venlafaxine Hydrochloride Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html \|website=Drugs.com \|publisher=AHFS \|accessdate=24 December 2018 \|archive-date=27 November 2020 \|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html \|url-status=live }}</ref> Kejadian efek samping yang umum terjadi seperti hilangnya nafsu makan, [[sembelit]], [[xerostomia]], [[pusing]], berkeringat, dan gangguan seksual. <ref name="AHFS2018"~~>{{Cite~~ ~~web\|title=Venlafaxine Hydrochloride Monograph for Professionals\|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html\|website=Drugs.com\|publisher=AHFS\|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html\|archive-date=27 November 2020\|access-date=24 December 2018\|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/venlafaxine-hydrochloride.html "Venlafaxine Hydrochloride Monograph for Professionals"]. </cite></ref> Kejadian efek samping yang cukup parah yakni meningkatkan risiko [[bunuh diri]], [[mania]], dan [[sindrom serotonin]] . <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Venlafaxine Hydrochloride Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html \|website=Drugs.com \|publisher=AHFS \|accessdate=24 December 2018 \|archive-date=27 November 2020 \|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html \|url-status=live }}</ref> Sindrom penarikan antidepresan dapat terjadi jika penggunaan obat ini dihentikan secara langsung. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Venlafaxine Hydrochloride Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html \|website=Drugs.com \|publisher=AHFS \|accessdate=24 December 2018 \|archive-date=27 November 2020 \|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html \|url-status=live }}</ref> Penggunaan obat ini untuk ibu hamil ditakutkan membahayakan bayinya. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Venlafaxine Hydrochloride Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html \|website=Drugs.com \|publisher=AHFS \|accessdate=24 December 2018 \|archive-date=27 November 2020 \|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html \|url-status=live }}</ref> Mekanis kerja obat ini belum diketahui secara jelas namun, dipercaya obat ini melibatkan perubahan [[neurotransmiter]] pada otak. <ref name="AHFS2018"~~>{{cite~~ ~~web \|title=Venlafaxine Hydrochloride Monograph for Professionals \|url=https:~~//www.drugs.com/monograph/venlafaxine-hydrochloride.html \|website=Drugs.com \|publisher=AHFS \|accessdate=24 December 2018 \|archive-date=27 November 2020 \|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html \|url-status=live }}</ref> Obat venlafaxine sendiri disetujui penggunaannya dalam medis di Amerika Serikat ditahun 1993. <ref name="AHFS2018" /> Obat venlafaxine sendiri disetujui penggunaannya dalam medis di Amerika Serikat ditahun 1993. <ref name="AHFS2018">{{Cite web\|title=Venlafaxine Hydrochloride Monograph for Professionals\|url=https://www.drugs.com/monograph/venlafaxine-hydrochloride.html\|website=Drugs.com\|publisher=AHFS\|archive-url=https://web.archive.org/web/20201127001402/https://www.drugs.com/monograph/venlafaxine-hydrochloride.html\|archive-date=27 November 2020\|access-date=24 December 2018\|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/venlafaxine-hydrochloride.html "Venlafaxine Hydrochloride Monograph for Professionals"]. </cite></ref> == Referensi == [[Kategori:~~Obat~~Antidepresan]] [[Kategori:~~Farmasi~~Obat yang dikembangkan oleh Pfizer]] [[Kategori:Obat yang dikembangkan oleh Wyeth]] [[Kategori:Penghambat CYP2D6]] [[Kategori:Penghambat penyerapan kembali serotonin-norepinefrin]] [[Kategori:Penghambat pengambilan kembali dopamin]] [[Kategori:Senyawa dimetilamino]] [[Kategori:Fenetilamina]] [[Kategori:Alkohol tersier]] [[Kategori:Agonis sigma]] [[Kategori:Senyawa 4-metoksifenil]] [[Kategori:Eter fenol]] <references />{{Farmasi-stub}}