Levonorgestrel: Perbedaan antara revisi
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{{Underlinked|date=Januari 2023}}
{{penyangkalan medis}}
{{Infobox drug
| Watchedfields = changed
| verifiedrevid = 462091161
| image = Levonorgestrel.svg
| width = 225
| image2 = Levonorgestrel molecule ball.png
| width2 = 235
<!--Clinical data-->
| tradename = Andalan postpil, Plan B, Julie, Mirena, Plan B One-Step, Liletta, dll
| Drugs.com = {{drugs.com|monograph|progestins-etonogestrel-levonorgestrel-norethindrone}}
| MedlinePlus = a610021
| pregnancy_AU = B3
| pregnancy_AU_comment = <ref name="Drugs.com pregnancy">{{cite web | title=Levonorgestrel Use During Pregnancy | website=Drugs.com | date=23 March 2020 | url=https://www.drugs.com/pregnancy/levonorgestrel.html | access-date=29 June 2020 | archive-date=2 July 2020 | archive-url=https://web.archive.org/web/20200702123750/https://www.drugs.com/pregnancy/levonorgestrel.html | url-status=live }}</ref>
| pregnancy_category = Dikontraindikasikan<ref name="Drugs.com pregnancy" />
| routes_of_administration = Oral, [[plester transdermal]], [[alat kontrasepsi dalam rahim]], [[implan subkutan]]
| class = [[Progestogen (medication)]]; [[Progestin]]
| ATC_prefix = G03
| ATC_suffix = AC03
| ATC_supplemental = {{ATC|G03|AD01}}
<!-- Legal status -->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment =
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = POM
| legal_UK_comment = <ref>{{cite web | title=Jaydess 13.5 mg intrauterine delivery system - Summary of Product Characteristics (SmPC) | website=(emc) | date=1 July 2022 | url=https://www.medicines.org.uk/emc/product/5297/smpc | access-date=1 July 2022 | archive-date=13 April 2021 | archive-url=https://web.archive.org/web/20210413020051/https://www.medicines.org.uk/emc/product/5297/smpc | url-status=live }}</ref>
| legal_US = Rx-only
| legal_US_comment = / OTC<ref name="Plan B One-Step FDA label">{{cite web | title=Plan B One-Step- levonorgestrel tablet | website=DailyMed | date=21 December 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6ce6b40e-14ac-47bd-a648-ddf9e452e559 | access-date=26 December 2022}}</ref>
| legal_EU =
| legal_EU_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment =
| legal_status = Rx/OTC
<!--Pharmacokinetic data-->
| bioavailability = 95% (kisaran 85–100%)<ref name="pmid16112947" /><ref name="pmid8842581" />
| protein_bound = 98% (50% menuju [[albumin serum manusia]], 48% menuju SHBG<ref name="pmid16112947" />
| metabolism = [[Hati]] ([[redoks|reduksi]], [[hidroksilasi]], [[biokonjugasi]])<ref name="pmid16112947" /><ref name="ShoupeHaseltine2012" />
| metabolites = • [[5α-Dihidrolevonorgestrel]]<ref name="pmid16112947" />
| elimination_half-life = 24–32 hours<ref name="pmid16112947" />
| excretion = [[Urin]]: 20–67%<br />[[feses]]: 21–34%<ref name="ShoupeHaseltine2012" />
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 797-63-7
| PubChem = 13109
| IUPHAR_ligand = 2881
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00367
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 12560
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 5W7SIA7YZW
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00950
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6443
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1389
| synonyms = LNG; LNG-EC; d-Norgestrel; d(–)-Norgestrel; <small>D</small>-Norgestrel; WY-5104; SH-90999; NSC-744007; 18-Metilnoretisteron; 17α-Etinil-18-metil-19-nortestosteron; 17α-Etinl-18-metilestr-4-en-17β-ol-3-ona; 13β-Etil-17α-hidroksi-18,19-dinorpregn-4-en-20-in-3-ona
<!--Chemical data-->
| IUPAC_name = (8''R'',9''S'',10''R'',13''S'',14''S'',17''R'')-13-etil-17-etinil-17-hidroksi-1,2,6,7,8,9,10,11,12,14,15,16-dodekahidrosiklopenta[''a'']fenantren-3-ona
| C=21 | H=28 | O=2
<!-- | LogP =3.8 unk param -->
| SMILES = CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = WWYNJERNGUHSAO-XUDSTZEESA-N
| melting_point = 235
| melting_high = 237
}}
[[Berkas:postinor2.jpg|jmpl|250px|Postinor, salah satu merek dagang dari levonorgestrel]]
Baris 33 ⟶ 115:
<references/>
[[Kategori:
[[Kategori:Obat yang dikembangkan oleh Bayer]]
[[Kategori:Senyawa etunil]]
[[Kategori:Steroid anabolik–androgenik]]
[[Kategori:Antigonadotropin]]
[[Kategori:Obat enantiomerik murni]]
[[Kategori:Enona]]
[[Kategori:Estrana]]
[[Kategori:Kontrasepsi hormonal]]
[[Kategori:Metabolit obat manusia]]
[[Kategori:Progestogen]]
[[Kategori:Alkohol tersier]]
[[Kategori:Obat Esensial Organisasi Kesehatan Dunia]]
{{medis-stub}}
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