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{{Short description|Chemical compound}}
'''Flutikason''' adalah senyawa [[glukokortikoid]] yang digunakan untuk mengobati gejala penyakit [[rongga hidung]].<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA574|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=574–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1337|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1337–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA124|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=124–}}</ref><ref name="Drugs.com">{{Cite web|url=https://www.drugs.com/international/fluticasone.html|title = Fluticasone - FDA prescribing information, side effects and uses}}</ref><ref name="Briggs_et_al2012" /> Baik esternya yakni flutikason propionat dan flutikason furoat, juga digunakan sebagai [[antiinflamasi]] topikal dan [[kortikosteroid]] inhalasi, dan lebih sering digunakan sebagai perbandingan.<ref name="MortonHall2012" /><ref name="IndexNominum2000" /><ref name="Drugs.com" /><ref name="SprattoWoods2012" />▼
{{Use dmy dates|date=October 2022}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 458449795
| image = Fluticasone.svg
| width = 200
<!--Clinical data-->
| Drugs.com =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =
| routes_of_administration = Intra[[Pemberian hidung|nasal]], inhalasi, [[Topikal]]
| ATC_prefix = D07
| ATC_suffix = AC17
| ATC_supplemental = {{ATC|R01|AD08}} {{ATC|R03|BA05}} {{ATC|R01|AD58}}
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
| legal_CA = OTC <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
<!--Pharmacokinetic data-->
| bioavailability = 0.51% (Intranasal)
| protein_bound = 91.0%
| metabolism = Intranasal<br />[[Hati]] ([[CYP3A4]]-dimediasi)
| elimination_half-life = 10 jam
| excretion = [[Ginjal]]
<!--Identifiers-->
| IUPHAR_ligand = 6699
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 90566-53-3
| PubChem = 5311101
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00588
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4470631
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = CUT2W21N7U
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07981
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 5134
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201396
| synonyms = 6α,9α-Difluoro-11β,17α-dihidroksi-16α-metil-21-tia-21-fluorometilpregna-1,4-dien-3,20-diona; ''S''-(Fluorometil)-6α,9α-difluoro-11β,17α-dihidroksi-16α-metil-3-oksoandrosta-1,4-diena-17β-karbotioat
<!--Chemical data-->
| IUPAC_name = ''S''-fluorometil (6''S'',8''S'',9''R'',10''S'',11''S'',13''S'',14''S'',16''R'',17''R'')-6,9-difluoro-11,17-dihidroksi-10,13,16-trimetil-3-okso-6,7,8,11,12,14,15,16-oktahidrosiklopenta[''a'']fenantrena-17-karbotioat
| C=22 | H=27 | F=3 | O=4 | S=1
| SMILES= O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MGNNYOODZCAHBA-GQKYHHCASA-N
}}
▲'''Flutikason''' adalah senyawa [[glukokortikoid]] yang digunakan untuk mengobati gejala penyakit [[rongga hidung]].<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA574|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=574–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1337|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1337–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA124|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=124–}}</ref><ref name="Drugs.com">{{Cite web|url=https://www.drugs.com/international/fluticasone.html|title = Fluticasone - FDA prescribing information, side effects and uses}}</ref><ref name="Briggs_et_al2012">{{cite book | vauthors = Briggs GG, Freeman RK, Yaffe SJ | title = Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk | publisher = Lippincott Williams & Wilkins | page = 600 | year = 2012 | isbn = 978-1451153590 | url = https://books.google.com/books?id=ScPvM03B3lUC&pg=PA600 }}</ref> Baik esternya yakni flutikason propionat dan flutikason furoat, juga digunakan sebagai [[antiinflamasi]] topikal dan [[kortikosteroid]] inhalasi, dan lebih sering digunakan sebagai perbandingan.<ref name="MortonHall2012" /><ref name="IndexNominum2000" /><ref name="Drugs.com" /><ref name="SprattoWoods2012">{{cite book | vauthors = Spratto GR, Woods AL | title = Delmar Nurse's Drug Handbook 2012 | publisher = Cengage Learning | page = 748 | year = 2012 | isbn = 978-1111310653 | url = https://books.google.com/books?id=x-f-kedg9ukC&pg=PA748 }}</ref>
Obat ini ada dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia]].<ref name="WHO22nd">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 22nd list (2021) | year = 2021 | hdl = 10665/345533 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2021.02 | hdl-access=free }}</ref> Pada tahun 2021, obat ini merupakan obat ke-23 yang paling sering diresepkan di Amerika Serikat, dengan lebih dari 25 juta resep,<ref>{{cite web | title=The Top 300 of 2021 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=14 January 2024 | archive-date=15 January 2024 | archive-url=https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title=Fluticasone - Drug Usage Statistics | website=ClinCalc | url=https://clincalc.com/DrugStats/Drugs/Fluticasone | access-date=14 January 2024}}</ref> meskipun obat ini juga dijual bebas.<ref>{{cite web |url=https://www.drugs.com/pro/fluticasone-nasal-spray.html |title=Fluticasone Nasal Spray |access-date=21 October 2022}}</ref>
Baris 5 ⟶ 62:
== Referensi ==
{{Reflist}}
[[Kategori:
[[Kategori:Kortikosteroid]]
[[Kategori:Antiinflamasi]]
[[Kategori:Obat Esensial Organisasi Kesehatan Dunia]]
[[Kategori:Diketon]]
[[Kategori:Diol]]
[[Kategori:Fluoroarena]]
[[Kategori:Glukokortikoid]]
[[Kategori:Pregnana]]
[[Kategori:Tioester]]
[[Kategori:Obat yang dikembangkan oleh GSK plc]]
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