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Kaspofungin: Perbedaan antara revisi

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Muhammad Anas Sidik (bicara | kontrib)
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Muhammad Anas Sidik (bicara | kontrib)
25.919 suntingan
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(7 revisi perantara oleh pengguna yang sama tidak ditampilkan)
Baris 16:
| pregnancy_AU_comment =
| pregnancy_category =
| routes_of_administration = [[Intravenous therapyInfus|IntravenousIntravena]]
| class =
| ATC_prefix = J02
Baris 44:
 
<!-- Pharmacokinetic data -->
| bioavailability = 100% (intravenoushanya useuntuk onlypenggunaan intravena)
| protein_bound = ~97%
| metabolism = [[LiverHati]]
| metabolites =
| onset =
| elimination_half-life = 9–11 hoursjam
| duration_of_action =
| excretion = [[KidneyGinjal]] (41%), [[fecesfeses]] (35%)
 
<!-- Identifiers -->
Baris 80:
| NIAID_ChemDB =
| PDB_ligand =
| synonyms = (4''R'',5''S'')-5-[(2-AminoethylAminoetil)amino]-''N''<sup>2</sup>-(10,12-dimethyltetradecanoyldimetiltetradekanoil)-<br />4-hydroxyhidroksi-L-ornithylornitil-L-threonyltreonil-''trans''-4-hydroxyhidroksi-L-prolylprolil-(''S'')-4-hydroxyhidroksi-4-(''p''-hydroxyphenylhidroksifenil)-L-threonyltreonil-''threotreo''-3-hydroxyhidroksi-L-ornithylornitil-''trans''-3-hydroxyhidroksi-L-prolineprolina cyclicsiklik (6→1)-peptidepeptida<br /><ref name="INN">{{cite web|title=International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names (Rec.INN): List 42|url=https://www.who.int/medicines/publications/druginformation/innlists/RL42.pdf|publisher=World Health Organization|access-date=11 November 2016|date=1999}}</ref>{{rp|185}}
1-[(4''R'',5''S'')-5-[(2-AminoethylAminoetil)amino]-''N''<sup>2</sup>-(10,12-dimethyldimetil-1-oxotetradecyloksotetradesil)-4-hydroxyhidroksi-L-ornithineornitina]-5-[(3''R'')-3-hydroxyhidroksi-L-ornithineornitina] pneumocandinpneumokandin B<sub>0</sub><ref name="Cancidas FDA label" />
 
<!-- Chemical and physical data -->
| IUPAC_name = (10''R'',12''S'')-''N''-{(2''R'',6''S'',9''S'',11''R'',12''S'',14a''S'',15''S'',20''S'',23''S'',25a''S'')-12-[(2-AminoethylAminoetil)amino]-20-[(1''R'')-3-amino-1-hydroxypropylhidroksipropil]-23-[(1''S'',2''S'')-1,2-dihydroxydihidroksi-2-(4-hydroxyphenylhidroksifenil)ethyletil]-2,11,15-trihydroxytrihidroksi-6-[(1''R'')-1-hydroxyethylhidroksietil]-5,8,14,19,22,25-hexaoxotetracosahydroheksaoksotetrakosahidro-1''H''-dipyrrolodipirolo[2,1-''c'':2',1'-''l''] [1,4,7,10,13,16]hexaazacyclohenicosinheksaazasiklohenikosin-9-ylil}-10,12-dimethyltetradecanamidedimetiltetradekanamida
| C=52 | H=88 | N=10 | O=15
| SMILES = [C@@]12(N(C[C@@H](C1)O)C([C@H]([C@@H](C)O)NC(=O)[C@](C[C@H]([C@@H](NCCN)NC([C@@H]3[C@H](CCN3C([C@H]([C@@H](CCN)O)NC(=O)[C@H]([C@@H]([C@H](C4=CC=C(C=C4)O)O)O)NC2=O)=O)O)=O)O)(NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)[H])=O)[H]
Baris 106:
}}
 
'''Kaspofungin''' ([[Nama Generik Internasional|INN]])<ref name="INN"/><ref>[http://www.emea.europa.eu/htms/human/epar/c.htm European Medicines Agency's list of authorised medicines for human use (C)] {{webarchive |url=https://web.archive.org/web/20071017030749/http://www.emea.europa.eu/htms/human/epar/c.htm |date=17 October 2007 }}</ref> adalah obat [[antijamur]] [[lipopeptida]] dariyang dikembangkan oleh [[Merck & Co.]], Inc..<ref name="Fungicides, antiprotozoa agents, microbiocides">{{cite web |title=Patent Covering Caspofungin |url=https://patents.google.com/patent/US5378804?oq=5378804 | access-date=18 March 2015}}</ref>
 
Caspofunginkaspofungin adalah penghambat pertama sintesis (1→3)-β-D-glukan jamur yang disetujui oleh [[Badan Pengawas Obat dan Makanan Amerika Serikat]].<ref name="Deresinski SC 2003 1445–1457">{{cite journal | vauthors = Deresinski SC, Stevens DA | title = Caspofungin | journal = Clinical Infectious Diseases | volume = 36 | issue = 11 | pages = 1445–57 | date = June 2003 | pmid = 12766841 | doi = 10.1086/375080 | doi-access = free }}</ref> CaspofunginKaspofungin diberikan secara [[infus|intravena]].<ref name="Cancidas FDA label">{{cite web | title=Cancidas- caspofungin acetate injection, powder, lyophilized, for solution | website=DailyMed | date=20 November 2023 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3bad23a6-09a6-4194-9182-093ed61bc71c | access-date=20 March 2024}}</ref> Obat ini tercantum dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia]].<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref>▼
 
▲Caspofungin adalah penghambat pertama sintesis (1→3)-β-D-glukan jamur yang disetujui oleh Badan Pengawas Obat dan Makanan Amerika Serikat.<ref name="Deresinski SC 2003 1445–1457">{{cite journal | vauthors = Deresinski SC, Stevens DA | title = Caspofungin | journal = Clinical Infectious Diseases | volume = 36 | issue = 11 | pages = 1445–57 | date = June 2003 | pmid = 12766841 | doi = 10.1086/375080 | doi-access = free }}</ref> Caspofungin diberikan secara intravena.<ref name="Cancidas FDA label" /> Obat ini tercantum dalam Daftar Obat Esensial Organisasi Kesehatan Dunia.<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref>
==Kegunaan dalam medis==
==Efek samping==
==Farmakologi==
Kaspofungin disintesis secara semisintesis dari pneumokandin B0, produk hasil fermentasi ''Glarea lozoyensis''.<ref name="Deresinski SC 2003 1445–1457" />
 
===Farmakokinetik===
Kaspofungin dimetabolisme secara perlahan melalui hidrolisis peptida dan ''N''-asetilasi di hati. Oleh karena itu, jika terjadi gangguan hati, dosisnya perlu dikurangi. Kaspofungin juga mengalami degradasi kimia spontan menjadi senyawa peptida cincin terbuka, L-747969. Metabolisme tambahan melibatkan hidrolisis menjadi asam amino konstitutif dan turunannya, termasuk dihidroksihomotirosina dan ''N''-asetil-dihidroksihomotirosina.<ref name="Cancidas FDA label" />
 
== Referensi ==
{{reflist}}
[[Kategori:Antijamur]]
[[Kategori:Ekinokandin]]
[[Category:Echinocandins]]
[[Kategori:Obat yang dikembangkan oleh Merck & Co.]]
[[Kategori:Obat Esensial Organisasi Kesehatan Dunia]]
{{Farmasi-stub}}
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