Natrium salisilat: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
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'''Natrium salisilat''' adalah garam [[natrium]] dari [[asam salisilat]]. Ia dapat dibuat dari [[natrium fenolat]] dan [[karbon dioksida]] pada suhu dan tekanan yang lebih tinggi. Secara historis, ia disintesis dengan mereflukskan [[metil salisilat]] (minyak [[gandapura]]) dengan [[natrium hidroksida]] berlebih.<ref>Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009</ref>
==Properti==
{{Expand section|date=Januari 2025}}
Natrium salisilat termasuk dalam keluarga [[asam salisilat|salisilat]]. Ia merupakan bubuk putih berkilau dengan rasa aromatik.<ref>{{Cite web |title=Sodium salicylate {{!}} 54-21-7 |url=https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |access-date=2024-09-02 |website=ChemicalBook |language=en |archive-date=2024-09-02 |archive-url=https://web.archive.org/web/20240902235509/https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |url-status=live }}</ref>
==Kegunaan==
Ia digunakan dalam pengobatan sebagai [[analgesik]] dan [[antipiretik]].<ref>{{Cite web |title=Sodium salicylate {{!}} 54-21-7 |url=https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |access-date=2024-09-02 |website=ChemicalBook |language=en |archive-date=2024-09-02 |archive-url=https://web.archive.org/web/20240902235509/https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm |url-status=live }}</ref> Natrium salisilat juga bertindak sebagai [[antiperadangan nonsteroid|obat antiinflamasi nonsteroid]] (OAINS), menginduksi [[apoptosis]] pada sel kanker,<ref>{{cite journal | title = Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines | journal = Blood | date = 1999-04-01 | first = Lidija | last = Klampfer |author2=Jörg Cammenga |author3=Hans-Georg Wisniewski |author4=Stephen D. Nimer | volume = 93 | issue = 7 | pages = 2386–94| doi = 10.1182/blood.V93.7.2386 | pmid=10090950}}</ref><ref>{{cite journal | title = Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis | journal = Proceedings of the National Academy of Sciences of the USA | date = 2007-07-31 | first = Colin | last = Rae |author2=Susana Langa |author3=Steven J. Tucker |author4=David J. MacEwan | volume = 104 | issue = 31 | pages = 12790–5| pmid=17646662 | pmc = 1937545 | doi=10.1073/pnas.0701437104| bibcode = 2007PNAS..10412790R | doi-access = free }}</ref><ref>{{cite journal | title = Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer | journal = Carcinogenesis | date = May 2007 | first = Lesley A. | last = Stark | volume = 28 | issue = 5 | pages = 968–76| pmid=17132819 | doi=10.1093/carcin/bgl220|display-authors=etal| doi-access = free }}</ref> dan juga [[nekrosis]].<ref>{{cite journal | title = Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate | journal = The Journal of Biological Chemistry | date = 1996-04-05 | first = Paul | last = Schwenger |author2=Edward Y. Skolnik |author3=Jan Vilcek | volume = 271 | issue = 14 | pages = 8089–94| pmid=8626494 | doi=10.1074/jbc.271.14.8089| doi-access = free }}</ref> Ia juga merupakan pengganti [[aspirin]] yang potensial bagi orang yang sensitif terhadapnya. Ia juga dapat digunakan sebagai fosfor untuk mendeteksi radiasi [[ultraungu|ultraviolet]] vakum dan radiasi [[partikel beta]].<ref>{{cite web|last=Samson|first=James|title=Vacuum Ultraviolet Spectroscopy|url=http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf|publisher=Pied Publications|access-date=July 26, 2012|url-status=dead|archive-url=https://web.archive.org/web/20061016104429/http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf|archive-date=October 16, 2006}}</ref>
==Referensi==
{{Reflist}}
== Pranala luar ==
{{Commons category}}
* [http://www.chemicalland21.com/lifescience/phar/SODIUM%20SALICYLATE.htm Chemicalland21]
* [http://vuahoachat.com vhc]
* [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5900&ncount=51#Synonyms Some synonyms]
* [http://physchem.ox.ac.uk/MSDS/SO/sodium_salicylate.html Safety data for sodium salicylate at Oxford University] {{Webarchive|url=https://web.archive.org/web/20060523222443/http://physchem.ox.ac.uk/MSDS/SO/sodium_salicylate.html |date=2006-05-23 }}
* [http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=43094 Sodium salicylate, definitions at National Cancer Institute]
[[Kategori:Garam natrium organik]]
[[Kategori:Salisilat]]
[[Kategori:3-Hidroksipropenal]]
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