Osteosit: Perbedaan antara revisi

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'''Osteosit''' adalah sejenis [[sel (biologi)|sel]] [[tulang]] dengan populasi sekitar 10 kali lipat populasi [[osteoblas]] dibandingkan dengan jumlah [[osteoklas]] yang jauh lebih sedikit daripada jumlah osteoblas.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/16036059
| title = Osteocyte and bone structure.
| accessdate = 2011-07-24
| work = ACTA-Vrije Universiteit, Department of Oral Cell Biology; Klein-Nulend J, Nijweide PJ, Burger EH.
}}</ref><ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981593
| title = Dynamics of the Transition from Osteoblast to Osteocyte
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}}</ref>
 
Sepanjang [[osteogenesis]], osteoblas akan melepaskan [[osteoid]] disertai peningkatan [[pencerap inti]] [[DAX1]] dan [[enzim]] [[GTPase]], dan penurunan [[faktor transkripsi]] [[SOX4]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/12704802
| title = Transcriptional profiling of human osteoblast differentiation.
| accessdate = 2011-07-24
| work = Women's Health Research Institute, Wyeth Research; Billiard J, Moran RA, Whitley MZ, Chatterjee-Kishore M, Gillis K, Brown EL, Komm BS, Bodine PV.
}}</ref> sebelum ter[[diferensiasi]] menjadi [['''osteosit]]'''.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/16258960
| title = Buried alive: how osteoblasts become osteocytes.
| accessdate = 2011-07-24
| work = Biology Department, Dalhousie University; Franz-Odendaal TA, Hall BK, Witten PE.
}}</ref> Sepanjang proses ini terjadi peningkatan
 
Osteosit memulai [[sekresi]] [[sklerostin]] setelah menjadi dewasa di dalam matriks osteoid yang mengalami [[mineralisasi]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386767
| title = Matrix Mineralization as a Trigger for Osteocyte Maturation
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[[Simtoma]] [[hipoksia]] akan dengan cepat menginduksi [[kluster diferensiasi]] [[osteopontin]] pada osteosit melalui [[lintasan metabolisme|lintasan]] [[protein kinase C]], dan memicu [[osteoklastogenesis]] yang menghasilkan [[osteoklas]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435734
| title = Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen
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== Rujukan ==
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[[Kategori:Sel]]
 
 
[[ca:Osteòcit]]
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[[de:Osteozyt]]
[[en:Osteocyte]]
[[es:Osteocito]]
[[fi:Osteosyytti]]
[[fr:Ostéocyte]]
[[ht:Osteyosit]]
[[it:Osteocita]]
[[ja:骨細胞]]
[[mk:Остеоцит]]
[[nl:Osteocyt]]
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[[pt:Osteócito]]
[[ru:Остеоциты]]
[[sk:Osteocyt]]
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[[tr:Osteosit]]