Purpura Henoch-Schönlein: Perbedaan antara revisi
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'''Purpura Henoch-Schönlein''' ({{lang-en|Henoch–Schönlein purpura, Henoch–Schönlein purpura nephritis, Anaphylactoid purpura,<ref name="Bolognia">{{cite book
| url = http://www.hawaii.edu/medicine/pediatrics/pedtext/s16c03.html
| title = Chapter XVI.3. Vasculitis
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}}</ref>
HSP ditandai oleh pengendapan [[kompleks imun]] [[antibodi A|IgA]]<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/7604640
| title = Henoch-Schönlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis.
| accessdate = 2010-04-30
| work = Department of Dermatology, Mayo Clinic; Helander SD, De Castro FR, Gibson LE.
}}</ref><ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/11148713
| title = Henoch-Schönlein purpura
| accessdate = 2010-04-30
| work = Division of Immunology and Rheumatology, Department of Pediatrics, University of Virginia Health System; Saulsbury FT
}}</ref> pada lapisan endotelial [[kulit]] dan [[ginjal]], turunnya rasio [[fibrinase|faktor XIII]]<ref>{{en}} {{cite web
| url = http://emedicine.medscape.com/article/209179-overview
| title = Factor XIII
| accessdate = 2010-04-30
| work = Wojewodzki Szpital Zespolony, University of Barcelona Faculty of Medicine, et al; Robert A Schwartz, Elzbieta Klujszo, et al
}}. Background, 7th paragraph.</ref> dan meningkatnya rasio [[komponen komplemen 3|C3]],<ref name="jasn hsp">{{en}} {{cite web
| url = http://jasn.asnjournals.org/cgi/content/full/10/12/2637
| title = Henoch-Schönlein Purpura Nephritis
| accessdate = 2010-04-30
| work = Harbor-UCLA Research and Education Institute, et al; ANUP RAI, CYNTHIA NAST dan SHARON ADLER
| archive-date = 2009-06-03
| archive-url = https://web.archive.org/web/20090603204432/http://jasn.asnjournals.org/cgi/content/full/10/12/2637
| dead-url = yes
}}</ref> [[protein reaktif C|CRP]] serta [[laju endap darah]].
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Rasio [[keping darah]] pada penderita HSP dapat meningkat dan merupakan ciri yang membedakan HSP dari penyakit serupa yang disertai penurunan rasio tersebut, seperti [[purpura idiopatik trombositopenik]] dan [[purpura trombotik trombositopenik]].<ref name=Kraft1998/>
HSP sering terjadi pada anak-anak. Gejala awal yang dirasakan berupa nyeri pada persendian yang disebut [[artralgia]] atau [[artritis]]<ref name=Kraft1998>{{cite journal |author=Kraft DM, Mckee D, Scott C |title=Henoch-Schönlein purpura: a review |journal=Am Fam Physician |volume=58 |issue=2 |pages=405–8, 411 |year=1998 |pmid=9713395 |url=http://www.aafp.org/afp/980800ap/kraft.html |access-date=2010-04-30 |archive-date=2011-06-06 |archive-url=https://web.archive.org/web/20110606052544/http://www.aafp.org/afp/980800ap/kraft.html |dead-url=yes }}</ref>
, diikuti dengan [[glomerulonefritis|radang pada ginjal]] dan pecahnya pembuluh darah kapiler pada lapisan endotelial [[kulit]] yang menyebabkan [[palpasi]] [[purpura]], dan [[saluran pencernaan]]<ref name="jasn hsp" /> yang menyebabkan [[konstipasi]], dan [[ginjal]] yang menyebabkan [[hematuria]]. Gejala ini sering disebut sebagai tetrad dari HSP.<ref name="uh XVI3"/>
== Patogenesis ==
HSP dapat terpicu setelah terjadi [[infeksi]] streptococci (β-haemolytic, Lancefield group A), hepatitis B, [[virus]] [[herpes]] simpleks, parvovirus B19, coxsackievirus, adenovirus, Helicobacter pylori, measles, mumps, rubella, mycoplasma dan penggunaan obat-obatan seperti vancomycin, ranitidine, [[streptokinase]], cefuroxime, diclofenac, enalapril dan captopril, vancomycin dan cefuroxime, antihypertensive ACE inhibitors enalapril dan captopril, antiinflammatory agent diclofenac, juga [[ranitidina]], yang kesemuanya dapat berpotensi menimbulkan reaksi idiosinkratik.<ref>{{en}} {{cite web
| url = http://en.wiki-indonesia.club/wiki/Talk:Henoch%E2%80%93Sch%C3%B6nlein_purpura
| title = Begin review notes for GA status
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}}</ref>
==
{{reflist}}
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* {{en}}[http://www.ncbi.nlm.nih.gov/pubmed/10191346?dopt=Abstract Glomerular membranopathy in children with IgA nephropathy and Henoch Schönlein purpura]. Department of Pathology, Saint Louis University School of Medicine; Vogler C, Eliason SC, Wood EG.
* {{en}}[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1717896 Selected references from Consultant Paediatric Nephrologist, Department of Paediatrics, Southmead Hospital]
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[[Kategori:Rematologi]]
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