|
! Notes
|-
| 1986
| ''[[Lucas (film)|Lucas]]''
|rina
| [[David Seltzer]]
|
|-
| 1987
| ''[[Square Dance (film)|Square Dance]]''
|gemma Dillard
| [[Daniel Petrie]]
|
|-
|rowspan="2"| 1988
|''[[Beetlejuice]]''
|lydia Deetz
| [[Tim Burton]]
|
|-
| ''[[1969 (film)|1969]]''
|beth Karr
| [[Ernest Thompson]]
|
|-
|rowspan="2"| 1989
| ''[[Heathers]]''
|veronica Sawyer
| [[Michael Lehmann]]
|
|-
| ''[[Great Balls of Fire! (film)|Great Balls of Fire!]]''
| [[Myra Gale Brown|Myra Gale Lewis]]
| [[Jim McBride]]
|
|-
|rowspan="3"| 1990
| ''[[Welcome Home, Roxy Carmichael]]''
|dinky Bossetti
| [[Jim Abrahams]]
|
|-
| ''[[Edward Scissorhands]]''
|kim Boggs
| [[Tim Burton]]
|
|-
| ''[[Mermaids (film)|Mermaids]]''
|charlotte Flax
| [[Richard Benjamin]]
|nominated — [[Golden Globe Award for Best Supporting Actress - Motion Picture|Golden Globe Award for Best Supporting Actress]]
|-
| 1991
| ''[[Night on Earth (film)|Night on Earth]]''
|corky
| [[Jim Jarmusch]]
|
|-
| 1992
| ''[[Dracula (1992 film)|Bram Stoker's Dracula]]''
| [[Mina Harker|Wilhelmina "Mina" Murray]]/Elisabeta
| [[Francis Ford Coppola]]
|
|-
|rowspan="2"| 1993
| ''[[The Age of Innocence (film)|The Age of Innocence]]''
|may Welland
| [[Martin Scorsese]]
| [[Golden Globe Award for Best Supporting Actress - Motion Picture|Golden Globe Award for Best Supporting Actress]]<br /> Nominated — [[Academy Award for Best Supporting Actress]]<br /> Nominated — BAFTA for Actress in a Supporting Role
|-
| ''[[The House of the Spirits (film)|The House of the Spirits]]''
|blanca Trueba
| [[Bille August]]
|
|-
|rowspan="3"| 1994
| ''[[Reality Bites]]''
|lelaina Pierce
| [[Ben Stiller]]
|
|-
| ''[[The Simpsons]]''
|allison Taylor
| [[Mark Kirkland]]
|
|-
| ''[[Little Women (1994 film)|Little Women]]''
|josephine "Jo" March
| [[Gillian Armstrong]]
|nominated — [[Academy Award for Best Actress]]
|-
| 1995
| ''[[How to Make an American Quilt]]''
|finn Dodd
| [[Jocelyn Moorhouse]]
|
|-
|rowspan="4"| 1996
| ''[[Boys (1996 film)|Boys]]''
|patty Vare
| [[Stacy Cochran]]
|
|-
| ''[[Dr. Katz, Professional Therapist]]''
|winona
|
| (voice)
|-
| ''[[Looking for Richard]]''
| [[Anne Neville|Lady Anne]]
| [[Al Pacino]]
| [[Documentary film]]
|-
| ''[[The Crucible (1996 film)|The Crucible]]''
| [[Abigail Williams]]
| [[Nicholas Hytner]]
|
|-
| 1997
| ''[[Alien Resurrection]]''
|annalee Call
| [[Jean-Pierre Jeunet]]
|
|-
|rowspan="2"| 1998
| ''[[Celebrity (film)|Celebrity]]''
|nola
| [[Woody Allen]]
|
|-
| ''[[The Larry Sanders Show]]''
|herself
| [[Thomas Schlamme]]
|
|-
| 1999
| ''[[Girl, Interrupted (film)|Girl, Interrupted]]''
| [[Susanna Kaysen]]
| [[James Mangold]]
|also [[executive producer]]
|-
|rowspan="3"| 2000
| ''[[Autumn in New York (film)|Autumn in New York]]''
|charlotte Fielding
| [[Joan Chen]]
|
|-
| ''[[Strangers with Candy]]''
|fran
|[[Juan J. Campanella]]
|-
| ''[[Lost Souls (film)|Lost Souls]]''
|maya Larkin
| [[Janusz Kamiński]]
|
|-
|rowspan="2"| 2001
| ''[[Zoolander]]''
|herself
| [[Ben Stiller]]
|uncredited cameo
|-
| ''[[Friends]]''
|melissa Warburton
| [[Gary Halvorson]]
| 1 episode
|-
|rowspan="2"| 2002
| ''[[Mr. Deeds]]''
|babe Bennett/Pam Dawson
| [[Steven Brill (scriptwriter)|Steven Brill]]
|
|-
| ''[[S1m0ne]]''
|nicola Anders
| [[Andrew Niccol]]
|
|-
| 2003
| ''The Day My God Died''
|narrator
| [[Andrew Levine]]
| [[Voice acting|Voice]], [[Film producer|producer]], [[documentary film]]
|-
| 2004
| ''[[The Heart Is Deceitful Above All Things]]''
|psychologist
| [[Asia Argento]]
|uncredited
|-
|rowspan="2"| 2006
| ''[[The Darwin Awards (film)|The Darwin Awards]]''
|siri
| [[Finn Taylor]]
|
|-
| ''[[A Scanner Darkly (film)|A Scanner Darkly]]''
|donna Hawthorne
| [[Richard Linklater]]
|
|-
|rowspan="3"| 2007
| ''[[The Ten]]''
|kelly LaFonda
| [[David Wain]]
|
|-
| ''[[Sex and Death 101]]''
|gillian De Raisx/Death Nell
| [[Daniel Waters]]
|
|-
| ''Welcome''<ref>{{cite web |url=http://www.psfilmfest.org/festival/film/detail.aspx?id=20134&FID=37 |title=''Welcome'' |publisher=Palm Springs International Film Festival - Shortfest |date=2007-08-23 |accessdate=2009-03-30}}</ref>
|Cynthia
|[[Kirsten Dunst]]
|Short film
|-
| 2008
| ''[[The Last Word (2008 film)|The Last Word]]''
|charlotte Morris
| [[Geoffrey Haley]]
|
|-
|rowspan="5" | 2009
| ''Water Pills''
|carrie
| [[Blake Soper]]
|short film
|-
| ''[[The Informers (film)|The Informers]]''
|cheryl Laine
| [[Gregor Jordan]]
|
|-
|''[[The Private Lives of Pippa Lee]]''
|sandra
| [[Rebecca Miller]]
|
|-
| ''[[Stay Cool]]''
|scarlet Smith
| [[Michael Polish]]
|
|-
| ''[[Star Trek (film)|Star Trek]]''
| [[Amanda Grayson]]
| [[J. J. Abrams]]
|
|-
|rowspan="2"|2010
| ''When Love Is Not Enough: The Lois Wilson Story''
| [[Lois Wilson (activist)|Lois Wilson]]
| [[John Kent Harrison]]
| ''Pre-production'', TV film
|-
| ''[[Black Swan (film)|Black Swan]]''
|
| [[Darren Aronofsky]]
| ''Pre-production
|}
!Result
|-
|rowspan="4" | 1990 || [[Independent Spirit Award]] ||best Female Lead || ''[[Heathers]]'' || {{award-nom}}
|-
| [[NBR Award]] ||best Supporting Actress || ''[[Mermaids (film)|Mermaids]]'' || {{award-won}}
|-
|shoWest Award ||female Star of Tomorrow || - || {{award-won}}
|-
| [[Young Artist Award]] ||best Young Artist Starring in a Motion Picture || ''[[Great Balls of Fire! (film)|Great Balls of Fire!]]'' || {{award-won}}
|-
| 1991 || [[Golden Globe]] ||best Performance by an Actress in a Supporting Role in a Motion Picture || ''[[Mermaids (film)|Mermaids]]'' ||{{award-nom}}
|-
|rowspan="2" | 1992 || [[Saturn Award]] ||best Actress ||rowspan="2" | ''[[Edward Scissorhands]]'' || {{award-nom}}
|-
|sant Jordi Award ||best Foreign Actress (Mejor Actriz Extranjera) || {{award-won}}
|-
|rowspan="3" | 1993 || [[Saturn Award]] ||best Actress ||rowspan="2" | ''[[Dracula (1992 film)|Bram Stoker's Dracula]]'' || {{award-nom}}
|-
| [[MTV Movie Award]] ||best Kiss || {{award-nom}}
|-
| [[NBR Award]] ||best Supporting Actress ||rowspan="4" | ''[[The Age of Innocence]]'' || {{award-won}}
|-
|rowspan="5" | 1994 || [[Academy Award]] ||best Actress in a Supporting Role || {{award-nom}}
|-
|bAFTA Film Award ||best Actress in a Supporting Role || {{award-nom}}
|-
| [[Golden Globe]] ||best Performance by an Actress in a Supporting Role in a Motion Picture || {{award-won}}
|-
| [[MTV Movie Award]] ||best Kiss || ''[[Reality Bites]]'' || {{award-nom}}
|-
|sEFCA Award ||best Supporting Actress || ''[[The Age of Innocence]]'' || {{award-won}}
|-
|rowspan="3" | 1995 || [[Academy Award]] ||best Actress in a Leading Role ||rowspan="3" | ''[[Little Women]]'' || {{award-nom}}
|-
|chlotrudis Award ||best Actress || {{award-nom}}
|-
| [[KCFCC Award]] ||best Actress || {{award-won}}
|-
| 1996 || [[MTV Movie Award]] ||best Kiss || ''[[How to Make an American Quilt]]'' || {{award-nom}}
|-
| 1997 ||shoWest Award ||female Star of the Year || - || {{award-won}}
|-
|rowspan="2" | 1998 || [[Saturn Award]] ||best Supporting Actress ||rowspan="2" | ''[[Alien Resurrection]]'' || {{award-nom}}
|-
| [[Blockbuster Entertainment Award]] ||favorite Supporting Actress - Sci-Fi || {{award-won}}
|-
|rowspan="3" | 2000 || [[Blockbuster Entertainment Award]] ||favorite Actress - Drama || ''[[Girl, Interrupted]]'' || {{award-nom}}
|-
|peter J. Owens Award || - || - || {{award-won}}
|-
|star on the Walk of Fame ||motion Picture || - || {{award-won}}
|-
| 2001 || [[Razzie Award]] ||worst Screen Couple || ''[[Autumn in New York (film)|Autumn in New York]]'' || {{award-nom}}
|-
| 2002 || [[Teen Choice Award]] ||film - Choice Actress, Comedy ||rowspan="2" | ''[[Mr. Deeds]]'' || {{award-nom}}
|-
| 2003 || [[Razzie Award]] ||worst Actress || {{award-nom}}
|-
| 2009 || [[Scream Award]] ||best Cameo || ''[[Star Trek (2009 film)|Star Trek]]'' || {{award-won}}
|}
| 