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Cheadle pertama kalinya mendapat perhatian luas atas perannya sebagai Mouse Alexander dalam film ''[[Devil in a Blue Dress (film)|Devil in a Blue Dress]]'', yang dengan itu ia memenangkan penghargaan Aktor Pendukung Terbaik dari [[Los Angeles Film Critics Association]] dan [[National Society of Film Critics]] serta dinominasikan pada penghargaan yang sama dari [[Screen Actors Guild]] dan[[NAACP Image Awards]]. Tak lama setelah itu, ia berperan dalam [[HBO]] TV 1996 ''[[Rebound: The Legend of Earl "The Goat" Manigault]]''. Dia juga membintangi film ''[[Volcano (1997 film)|Volcano]]''1997 yang disutradari oleh [[Mick Jackson (director)|Mick Jackson]].{{citation needed|date=June 2015}}
Karya-karya televisi Cheadle's televisiontermasuk creditspenampilan includenominasi -[[Emmy]]-nominated performancesdalam in the moviesfilm-film ''[[The Rat Pack (film)|The Rat Pack]]'', ''[[A Lesson Before Dying]]'', ''[[Things Behind the Sun]]'' and indan asebagai guestbintang appearancetamu ondalam ''[[ER (TV series)|ER]]''. The last of these spanned four episodes during the show's ninth season, in which he portrayed Paul Nathan, a medical student struggling to cope with [[Parkinson's disease]]. He has made appearances in films including ''[[Rosewood (film)|Rosewood]]'', ''[[The Family Man]]'', ''[[Boogie Nights]]'', a cameo appearance in the film ''[[Abby Singer (film)|Abby Singer]]'', ''[[Out of Sight (1998 film)|Out of Sight]]'', ''[[Traffic (2000 film)|Traffic]]'', and ''[[Ocean's Eleven]]''. These last three were directed by [[Steven Soderbergh]]. In 2005, Cheadle was nominated for the [[Academy Award for Best Actor]] for his portrayal of [[Paul Rusesabagina]] in the film ''[[Hotel Rwanda]]''. He also starred in and co-produced ''[[Crash (2004 film)|Crash]]'', which won the 2005 [[Academy Award for Best Picture]]. For his performance in ''Crash'', Cheadle was nominated for the [[BAFTA]] and [[Screen Actors Guild]] Awards for Best Supporting Actor. He played the main character in the movie ''[[Traitor (film)|Traitor]]''. In March 2007, Cheadle starred with comedian [[Adam Sandler]] in Mike Binder's ''[[Reign Over Me]]'', a comedy-drama about a man who has slipped away from reality after his wife and three daughters died. After playing for 38 days, the film became a [[box office bomb|box office flop]] earning a domestic gross of only 22.2 million. Cheadle later starred in the 2009 DreamWorks Pictures film ''[[Hotel for Dogs]]''.<ref>{{cite web|url=http://www.azcentral.com/ent/movies/articles/2008/10/14/20081014cheadle.html|title=Don Cheadle joins 'Iron Man 2'|publisher=Azcentral.com|date=October 14, 2008|accessdate=July 28, 2010}}</ref><ref>{{cite web|url=http://www.movieweb.com/news/NEDZSGFF0tRZIE|title=Don Cheadle Joins Hotel for Dogs |publisher=Movieweb.com|accessdate=July 28, 2010}}</ref>
In 2007, Cheadle published a book, ''[[Not on Our Watch]]: The Mission to End Genocide in Darfur and Beyond'', co-authored with [[John Prendergast (activist)|John Prendergast]]. Cheadle was to make his directorial debut with the adaptation of [[Elmore Leonard]]'s ''[[Tishomingo Blues (novel)|Tishomingo Blues]]''. In a July 2007 interview he stated, "'Tishomingo' is dead..."<ref name=autogenerated1>{{cite web|url=http://www.comingsoon.net/news/movienews.php?id=21703 |title=Don Cheadle Talks to Us |publisher=Comingsoon.net |date=July 6, 2007 |accessdate=July 28, 2010}}</ref>
In September 2015, Cheadle appeared (also as a red bird version of himself) in the promo ad for the Champions for Earth tournament in ''[[Angry Birds Friends]]''.
==PersonalKehidupan lifePribadi==
[[File:Don Cheadle 2007.jpg|thumb|Cheadle in February 2007]]
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