Abakavir: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
Dibuat dengan menerjemahkan halaman "Abacavir" |
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{{Drugbox
| Watchedfields = changed
| verifiedrevid = 477236809
| IUPAC_name = {(1''S'',4''R'')-4-[2-amino-6-(cyclopropylamino)-9''H''-purin-9-yl]cyclopent-2-en-1-yl}methanol
| image = Abacavir.svg
| width = 200
| image2 = Abacavir ball-and-stick model.png
| caption = Struktur kimia dari Abakavir
<!--Clinical data-->
|pronounce = {{IPAc-en|audio=en-abacavir.ogg|ʌ|.|b|æ|k|.|ʌ|.|v|ɪər}}
| tradename = Ziagen
| Drugs.com = {{drugs.com|monograph|abacavir-sulfate}}
| MedlinePlus = a699012
| pregnancy_AU = B3
| pregnancy_US = C
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = Peroral (larutan atau tablet)
<!--Pharmacokinetic data-->
| bioavailability = 83%
| metabolism = [[Hati|Hepatik]]
| elimination_half-life = 1.54 ± 0.63 jam
| excretion = [[Ginjal|Renal]] (1.2% abakavir, 30% metabolit 5'-asam karboksilat, 36% metabolit 5'-glukuronida, 15% metabolit minor tak diketahui). Feses (16%)
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 136470-78-5
| ATC_prefix = J05
| ATC_suffix = AF06
| PubChem = 441300
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01048
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 390063
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = WR2TIP26VS
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07057
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 421707
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1380
| NIAID_ChemDB = 028596
<!--Chemical data-->
| C=14 | H=18 | N=6 | O=1
| molecular_weight = 286.332 g/mol
| melting_point = 165
| smiles = n3c1c(ncn1[C@H]2/C=C\[C@@H](CO)C2)c(nc3N)NC4CC4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MCGSCOLBFJQGHM-SCZZXKLOSA-N
}}
'''Abakavir''' ('''ABC''') merupakan [[obat antiretroviral]] yang digunakan untuk mencegah dan mengobati [[AIDS|HIV/AIDS]].<ref name="AHFS2015">{{Cite web|title=Abacavir Sulfate|url=http://www.drugs.com/monograph/abacavir-sulfate.html|publisher=The American Society of Health-System Pharmacists|accessdate=31 July 2015}}</ref> Galur virus yang resisten terhadap [[zidovudin]] (AZT) atau [[lamivudin]] (3TC) umumnya sensitif terhadap abakavir, walau tidak selalu demikian.
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